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Ming-Lin Liu, MBBS, PhD
50Research Associate Professor of Dermatology
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Department: Dermatology
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Contact information
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Department of Dermatology
30 University of Pennsylvania Health System
23 Perelman School of Medicine
22 University of Pennsylvania
25 2 East. Gates Building, #2021
35 3600 Spruce Street
Philadelphia, PA 19104
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30 University of Pennsylvania Health System
23 Perelman School of Medicine
22 University of Pennsylvania
25 2 East. Gates Building, #2021
35 3600 Spruce Street
Philadelphia, PA 19104
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Email:
lium1@pennmedicine.upenn.edu
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lium1@pennmedicine.upenn.edu
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Publications
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Education:
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33 Tianjin Medical University, 1986.
21 8 PhD c
2f University of Helsinki, 2003.
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21 9 MBBS c
33 Tianjin Medical University, 1986.
21 8 PhD c
2f University of Helsinki, 2003.
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Links
e3 Search PubMed for articles
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Permanent linke3 Search PubMed for articles
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ac 2) Mechanistic studies on programmed cell death (e.g., NETosis), regulation of EV generation and NET formation, and their roles in innate immunity and autoimmunity.
b3 3) Pathogenesis of autoimmune diseases, including SLE, Dermatomyositis, and Vasculitis, as mediated by EVs and NETs, with their modulation by UV light and tobacco smoking.
ab 4) Studies on the role of EVs in cardiometabolic and vascular pathology, and how tobacco smoking modulates EV release and function to drive the disease progression.
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Description of Research Expertise
d3 1) Expertise in the function of Extracellular Vesicles (EVs) and Neutrophil Extracellular Traps (NETs) as critical mediators of cell-to-cell communication and inflammation in health and disease.ac 2) Mechanistic studies on programmed cell death (e.g., NETosis), regulation of EV generation and NET formation, and their roles in innate immunity and autoimmunity.
b3 3) Pathogenesis of autoimmune diseases, including SLE, Dermatomyositis, and Vasculitis, as mediated by EVs and NETs, with their modulation by UV light and tobacco smoking.
ab 4) Studies on the role of EVs in cardiometabolic and vascular pathology, and how tobacco smoking modulates EV release and function to drive the disease progression.
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1c0 Singh J, Boettcher M, Dolling M, Jeuer A, Hohberger B, Leppkes M, Naschberger E, Schapher M, Schauer C, Schoen J, Sturzl M, Vitkov L, Wang H, Zlatar L, Schett GA, Pisetsky DS*, Liu ML*, Herrmann M*, Knopf J*.: Moonlighting chromatin: when DNA escapes nuclear control. Cell Death Differ. 30: 861-875, February 2023 (*Co-senior authors). Notes: doi: 10.1038/s41418-023-01124-1
116 Li MH, Lyu X, Liao J, Werth VP, Liu ML*: Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation (doi: 10.7150/thno.66457). Theranostics. 12(5): 2133, Feburary 2022.
136 Li YB, Li MH, Weigel B, Mall M, Werth VP, Liu ML*: Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly (doi: 10.15252/embr.201948779). EMBO Reports 21(8): e48779, June 2020 (*Corresponding Author)
141 Zhao Y, Wei W*, Liu ML*: Extracellular Vesicles and Lupus Nephritis - New insights into pathophysiology and clinical implications (doi: 10.1016/j.jaut.2020.102540). Journal of Autoimmunity. Elsevier, 113, September 2020 (*Co-corresponding Authors).
115 Liu ML*: Functional actin cytoskeleton is required in early stage of NETosis induction. (Letter-to-the-editor). Proc. Natl. Acad. Sci. U.S.A. 117(37): 22653-22654, September 2020 (*Corresponding Author)
19f Luan J, Chen W, Fan J, Wang S, Zhang X, Zai W, Jin X, Wang Y, Feng Z, Zhang J, Liu ML*, Ju D*.: GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis. Biomaterials 227(119570), January 2020 (* Co-corresponding Authors)
115 Wu X, Liu Y, Wei W*, Liu ML* : Extracellular Vesicles in Autoimmune Vasculitis - Little dirts light the fire in blood vessels. Autoimmunity Reviews 18(6): 593-606, June 2019 (* Co-corresponding Authors).
fa ML Liu*, KJ Williams, VP Werth: Microvesicles in Autoimmune Diseases. (Invited Review Article). Advances in Clinical Chemistry 77: 125-175 Jul 2016 (* Corresponding Author).
1a0 Liu ML*, Reilly MP, Peter Casasanto, McKenzie SE, Williams KJ*.: Cholesterol Enrichment of Human Monocyte/Macrophages Induces Surface Exposure of Phosphatidylserine and the Release of Biologically-Active Tissue Factor-Positive Microvesicles. Arteriosclerosis, Thrombosis, and Vascular Biology. 27(2): 430-5, 2007 (* Co-corresponding Authors).
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Selected Publications
153 Zhao Y, Lyu X, Wu X, Liu Y, Zhang N, Wei W*, Liu ML*: Novel Perspectives on Extracellular Vesicles in Autoimmune Diseases: Immunogenicity, Inflammation, and Immune Surveillance. Journal of Clinical Investigation 136(3), Feb 2026 Accepted (*Co-Corresponding authors).1c0 Singh J, Boettcher M, Dolling M, Jeuer A, Hohberger B, Leppkes M, Naschberger E, Schapher M, Schauer C, Schoen J, Sturzl M, Vitkov L, Wang H, Zlatar L, Schett GA, Pisetsky DS*, Liu ML*, Herrmann M*, Knopf J*.: Moonlighting chromatin: when DNA escapes nuclear control. Cell Death Differ. 30: 861-875, February 2023 (*Co-senior authors). Notes: doi: 10.1038/s41418-023-01124-1
116 Li MH, Lyu X, Liao J, Werth VP, Liu ML*: Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation (doi: 10.7150/thno.66457). Theranostics. 12(5): 2133, Feburary 2022.
136 Li YB, Li MH, Weigel B, Mall M, Werth VP, Liu ML*: Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly (doi: 10.15252/embr.201948779). EMBO Reports 21(8): e48779, June 2020 (*Corresponding Author)
141 Zhao Y, Wei W*, Liu ML*: Extracellular Vesicles and Lupus Nephritis - New insights into pathophysiology and clinical implications (doi: 10.1016/j.jaut.2020.102540). Journal of Autoimmunity. Elsevier, 113, September 2020 (*Co-corresponding Authors).
115 Liu ML*: Functional actin cytoskeleton is required in early stage of NETosis induction. (Letter-to-the-editor). Proc. Natl. Acad. Sci. U.S.A. 117(37): 22653-22654, September 2020 (*Corresponding Author)
19f Luan J, Chen W, Fan J, Wang S, Zhang X, Zai W, Jin X, Wang Y, Feng Z, Zhang J, Liu ML*, Ju D*.: GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis. Biomaterials 227(119570), January 2020 (* Co-corresponding Authors)
115 Wu X, Liu Y, Wei W*, Liu ML* : Extracellular Vesicles in Autoimmune Vasculitis - Little dirts light the fire in blood vessels. Autoimmunity Reviews 18(6): 593-606, June 2019 (* Co-corresponding Authors).
fa ML Liu*, KJ Williams, VP Werth: Microvesicles in Autoimmune Diseases. (Invited Review Article). Advances in Clinical Chemistry 77: 125-175 Jul 2016 (* Corresponding Author).
1a0 Liu ML*, Reilly MP, Peter Casasanto, McKenzie SE, Williams KJ*.: Cholesterol Enrichment of Human Monocyte/Macrophages Induces Surface Exposure of Phosphatidylserine and the Release of Biologically-Active Tissue Factor-Positive Microvesicles. Arteriosclerosis, Thrombosis, and Vascular Biology. 27(2): 430-5, 2007 (* Co-corresponding Authors).
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