Parker C. Wilson, MD, PhD
Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
713B Stellar-Chance Laboratories Building
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215 746 4321
Lab: 215 746 4321
Lab: 215 746 4321
Education:
BS (Engineering with a Concentration in Computer Science)
Johns Hopkins University, 2005.
MD, PhD (Molecular and Cellular Biology and Pathobiology)
Medical University of South Carolina, 2013.
BS (Engineering with a Concentration in Computer Science)
Johns Hopkins University, 2005.
MD, PhD (Molecular and Cellular Biology and Pathobiology)
Medical University of South Carolina, 2013.
Post-Graduate Training
Residency, Anatomic and Clinical Pathology, Yale New Haven Hospital, 2013-2017.
Clinical Fellowship, Renal and Genitourinary Pathology, Yale New Haven Hospital, 2017-2018.
Clinical Fellowship, Molecular Genetic Pathology, Washington University School of Medicine, St. Louis, MO, 2018-2019.
Permanent linkResidency, Anatomic and Clinical Pathology, Yale New Haven Hospital, 2013-2017.
Clinical Fellowship, Renal and Genitourinary Pathology, Yale New Haven Hospital, 2017-2018.
Clinical Fellowship, Molecular Genetic Pathology, Washington University School of Medicine, St. Louis, MO, 2018-2019.
Selected Publications
Ihara K, Satake E, Wilson PC, Krolewski B, Kobayashi H, Md Dom ZI, Ricca J, Wilson J, Dreyfuss JM, Niewczas MA, Doria A, Nelson RG, Pezzolesi MG, Humphreys BD, Duffin K, Krolewski AS: Circulating proteins linked to apoptosis processes and fast development of end-stage kidney disease in diabetes. JCI Insight October 2024 Notes: Dr. Wilson conducted all of the single-cell analysis in this paper and demonstrated that the circulating proteins predictive of kidney disease progression likely originate from a specific population of injured proximal tubule cells.Agraz JL, Agraz C, Chen AA, Rice C, Pozos RS, Aelterman S, Tan A, Viaene AN, Nasrallah MP, Sharma P, Grenko CM, Kurc T, Saltz J, Feldman MD, Akbari H, Shinohara RT, Bakas S, Wilson P: Optimized Whole-Slide-Image H&E Stain Normalization: A Step Towards Big Data Integration in Digital Pathology. IEEE Open J Eng Med Biol September 2024.
Wallwork RS, Kotzin JJ, Cappelli LC, Mecoli C, Bingham CO 3rd, Wigley FM, Wilson PC, DiRenzo DD, Shah AA: Immune checkpoint inhibitor therapy in patients with cancer and pre-existing systemic sclerosis. Semin Arthritis Rheum May 2024 Notes: Contributed renal histology images of patients with systemic scleroderma.
Ledru N, Wilson PC, Muto Y, Yoshimura Y, Wu H, Li D, Asthana A, Tullius SG, Waikar SS, Orlando G, Humphreys BD: Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing. Nat Communications Feb 2024 Notes: Provided original analysis and mentorship for first-author to generate single-cell atlas from multiome data.
Wilson PC, Verma A, Yoshimura Y, Muto Y, Li H, Malvin NP, Dixon EE, Humphreys BD: Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease. Genome Biology January 2024 Notes: First-corresponding author. Demonstrate cell-specific loss of Y chromosome. Novel techniques for estimating the fraction of cells with loss of Y chromosome - implications for detection of somatic mosaicism in other organs.
Tarek Alhamad (Editor): Washington Manual of Transplant Pathology. Wolters Kluwer. Wolters Kluwer, October 2023 Notes: Wrote chapter on antibody-mediated rejection.
Han SK, McNulty MT, Benway CJ, Wen P, Greenberg A, Onuchic-Whitford AC; Nephrotic Syndrome Study Network (NEPTUNE); Jang D, Flannick J, Burtt NP, Wilson PC, Humphreys BD, Wen X, Han Z, Lee D, Sampson MG.: Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs. Nat Commun 14: 2229, Apr 2023.
Han SK, Muto Y, Wilson PC, Humphreys BD, Sampson MG, Chakravarti A, Lee D.: Quality assessment and refinement of chromatin accessibility data using a sequence-based predictive model. Proc Natl Acad Sci U S A 119: e2212810119, Dec 2022.
Mantrala S, Ginter PS, Mitkari A, Joshi S, Prabhala H, Ramachandra V, Kini L, Idress R, D'Alfonso TM, Fineberg S, Jaffer S, Sattar AK, Chagpar AB, Wilson P, Singh K, Harigopal M, Koka D.: Concordance in Breast Cancer Grading by Artificial Intelligence on Whole Slide Images Compares With a Multi-Institutional Cohort of Breast Pathologists. Arch Pathol Lab Med 146: 1369-1377, Nov 2022.
Muto Y, Dixon EE, Yoshimura Y, Wu H, Omachi K, Ledru N, Wilson PC, King AJ, Eric Olson N, Gunawan MG, Kuo JJ, Cox JH, Miner JH, Seliger SL, Woodward OM, Welling PA, Watnick TJ, Humphreys BD.: Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis. Nat Commun 13: 6497, Oct 2022.
Contact us
Institute for Diabetes, Obesity and Metabolism
Smilow Center for Translational Research
3400 Civic Center Boulevard, 12th Floor
Philadelphia, PA 19104
Phone: 215-898-0198 | Fax 215-898-5408
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