Perelman School of Medicine at the University of Pennsylvania

Bashaw Lab

Sparse labeling of embryonic motor neurons

A subset of embryonic Drosophila motor neurons are labeled using a genetic technique that allows for single cell resoultion.

Current Lab Members


Faculty

Greg J. Bashaw, Ph.D.

Greg J. Bashaw, Ph.D.
Professor of Neuroscience
 gbashaw@pennmedicine.upenn.edu

 

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Greg completed his Ph.D. at Stanford University in the lab of Bruce Baker. His thesis research investigated the molecular mechanisms underlying the regulation of X chromosome dosage compensation in Drosophila. He found that the master splicing regulator Sex-lethal inhibits the formation of the dosage compensation complex in female flies through translational repression of the Male-specific lethal 2 gene (Msl-2). From Stanford, Greg moved across the bay for a postdoctoral fellowship in developmental neurobiology in the lab of Corey Goodman at UC Berkeley. In the Goodman lab, Greg began his studies of the molecular mechanisms that control axon guidance in the embryonic Drosophila CNS. His work in the Goodman lab focused on the signaling mechanisms downstream of the conserved axon guidance receptors Frazzled and Robo. He showed that differential attractive and repulsive responses are encoded in receptor cytoplasmic domains and identified several signaling components that act downstream of the Robo receptor to regulate axon repulsion. Greg started his lab at the University of Pennsylvania in 2001 where he is currently a Professor of Neuroscience.



Postdoctoral Fellows

Camila Barrios-Camacho, Ph.D

Camila Barrios-Camacho, Ph.D
Penn PORT Postdoctoral Fellow
 Camila.BarriosCamacho@Pennmedicine.upenn.edu

Camila completed her BA in Philosophy and in Biology at Grinnell College, where she was a Posse Foundation scholar. Following her tenure as an AmeriCorps Urban Education Fellow, she was PREP scholar in Abe Palmer's lab at the University of Chicago where she studied the epistatic effects of the Akita mouse mutant allele on physiological and behavioral phenotypes in a panel of F1 mice. She then completed her PhD in Jim Schwob's lab at Tufts University, where she studied the activation of the dormant neural stem cells of the olfactory epithelium. As a postdoc in the Bashaw lab, she is studying how the ICD of the Fra receptor orchestrates the transcriptional networks involved in axonal midline crossing. Outside of lab, she enjoys cultivating her fermentation hobby, trying new hot sauces, playing board games, exploring the world on her bike, and spending time with her dog BamBam.


Kaitlin Laws, Ph.D.

Kaitlin Laws, Ph.D.
Penn PORT Postdoctoral Fellow
 klaws@pennmedicine.upenn.edu

Kate earned her Ph.D. in the lab of Daniela Drummond-Barbosa at Johns Hopkins where her research focused on the physiological control of Drosophila oogenesis. She is investigating the transcriptional regulation of motor neuron differentiation and maintenance in the larval Drosophila nervous system.



Graduate Students

Olivia Fish

Olivia Fish
Graduate Student CAMB (G&E)
 Olivia.Fish@Pennmedicine.upenn.edu

Olivia graduated from the University of Alabama in May 2019 with a BS in biology and a BA in dance. She performed undergraduate research in Dr. Laura Reed’s lab, where she studied the evolution of toxin tolerance in mushroom feeding species of Drosophila. After graduation, Olivia
worked as a post baccalaureate trainee in Dr. Kelly Ten Hagen’s lab at the National Institutes of Health. Here, she used single-cell RNA sequencing on Drosophila salivary glands to study the mechanisms by which heavily glycosylated proteins are secreted. In the Bashaw lab, Olivia is developing projects relate to axon guidance receptor regulation and signaling.


Sarah Gagnon

Sarah Gagnon
Graduate Student CAMB (DSRB)
 sgagnon@pennmedicine.upenn.edu

Sarah earned her BSc and MSc in cell biology from McGill University, Canada, where she studied intracellular trafficking and small RNAs in C. elegans. She then moved to Philly and made the jump to flies to pursue her interest in developmental biology and axon guidance. Her thesis work investigates how axons change their responsiveness to midline-derived cues as they approach, cross, and grow away from the midline.


Maya Hale

Maya Hale
Graduate Student CAMB-DSRB
 Maya.Hale@pennmedicine.upenn.edu

Maya earned her BS and BA at University of Maryland, Baltimore County. Her research explores the molecular mechanisms of axon guidance in the mammalian central nervous system. More specifically, she is investigating the regulation of Robo receptors via E3 ubiquitin ligase-mediated degradation in the developing spinal cord and during the development of the corpus callosum.


Kelly Sullivan

Kelly Sullivan
Graduate Student CAMB-DSRB
 kellysul@pennmedicine.upenn.edu

Kelly did her undergraduate studies at Tufts. Her thesis work is exploring the regulation of repulsive axon guidance receptors during axon guidance at the midline. In particular, she is investigating intracellular trafficking mechanisms that control Robo receptor surface expression.


Yixin Zang

Yixin Zang
Graduate Student CAMB-DSRB
 yzang@pennmedicine.upenn.edu

Bio: I grew up in the metropolitan area in Beijing, China, then went to the small college town Ithaca in upstate NY for my college education at Cornell University. In my free time I like to spend time with my orange Tabby cat Orange, who is a master of being annoying but still endearing.

Research: During development, the establishment of correct neural circuits through guided axon extension is essential for the function of the nervous system. In a newly discovered pathway, one of the classical axon guidance receptors Frazzled can be cleaved to act as a transcription factor to activate target gene expression. My thesis project focuses on understanding the upstream genes required to regulate Fra proteolytic cleavage and downstream target gene expression.



Lab Manager/ Research Specialist

Chloe A. Potter

Chloe A. Potter
Lab Manager/Senior Research Specialist
 Chloe.Potter@Pennmedicine.upenn.edu

Chloe earned her undergraduate degree in Animal Sciences from Cornell University. Since then, she has worked with the mouse model in ophthalmology and developmental biology research labs before coming to the University of Pennsylvania. She is excited to apply her technical knowledge to neuroscience and develop new skill sets as well as help maintain a well functioning, proficient laboratory.