Publications
2023
Zang Y. and Bashaw G.J. (2023) Systematic analysis of the Frazzled receptor interactome establishes previously unreported regulators of axon guidance. Development in press.
Chaudhari K.*, Zhang K.*, Yam P.T., Zang Y., Kramer D.A., Schlienger S., Calabretta S., Collins M., Srour M., Chen B., Charron F., Bashaw G.J. (2023) A human DCC variant causing mirror movement disorder reveals an essential role for the Wave regulatory complex in Netrin/DCC signaling. bioRxiv. *equal contribution.
Laws K.M., Natale E., Waddell E.A., Shuda J.R. and Bashaw G.J. (2023) DrosoPHILA: a partnership between scientists and teachers that begins in the lab and continues into city schools. eNeuro. 2023 Feb 13;10(2):ENEURO.0263-22.2022. doi: 10.1523/ENEURO.0263-22.2022. Print 2023 Feb.
Sullivan K.G. and Bashaw G.J. (2023) Intracellular Trafficking Mechanisms that Regulate Repulsive Axon Guidance. Neuroscience. 2023 Jan 1;508:123-136. doi: 10.1016/j.neuroscience.2022.07.012. Epub 2022 Jul 18.
2022
Zang Y., Chaudhari K., and Bashaw G.J. (2022) Tace/ADAM17 is a bi-directional regulator of axon guidance that coordinates distinct Frazzled and Dcc receptor signaling outputs. Cell Reports, Featured on the Cover. Dec 6;41(10):111785. doi: 10.1016/j.celrep.2022.111785
Gorla M., Chaudhari K., Hale M., Potter C. and Bashaw G.J. (2022) A Nedd4 E3 Ubiquitin ligase pathway inhibits Robo1 repulsion and promotes commissural axon guidance across the midline. Journal of Neuroscience, 42(40):7547-61.
Laws K.M. and Bashaw G.J. (2022) Diverse roles for axon guidance pathways in adult tissue architecture and function. Natural Sciences. 2022 Oct;2(4):e20220021. doi: 10.1002/ntls.20220021. Epub 2022 Oct 2.
2021
Russell SA, Laws KM, Bashaw G.J. (2021) Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis. Development, 148(24):dev199762. doi: 10.1242
Chaudhari K., Gorla M., Chang C., Kania A., Bashaw G.J. (2021) Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion. eLife, 10:e64474.
Daiber T., VanderZwan-Butler C.J., Bashaw G.J., Evans T.A. (2021) Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3. Genetics, 217(3):iyab018.
Zang Y, Chaudhari K, and Bashaw G.J. (2021) New insights into the molecular mechanisms of axon guidance receptor regulation and signaling. Current Topics in Developmental Biology, 142:147-196.
2020
Gorla M and Bashaw G.J. (2020) Molecular mechanisms regulating axon responsiveness at the midline. Developmental Biology, 466(1-2):12-21.
2019
Simonetti, B., Paul, B., Chaudhari, K., Weeratunga, S., Steinberg, F., Gorla, M., Heesom, K.J., Bashaw, G. J., Collins, B.M., and Cullen, P.J. (2019). Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Nature Cell Biology
Gorla M, Santiago C, Chaudhari K, Layman AAK, Oliver PM, Bashaw GJ (2019). Ndfip proteins target Robo receptors for degradation and allow commissural axons to cross the floor plate in the developing spinal cord. Cell Reports
2018
Arbeille, E and Bashaw, G.J. (2018). Brain Tumor promotes axon growth across the midline through interactions with the microtubule stabilizing protein Apc2. PLoS Genetics
Russell, S.A. and Bashaw, G.J. (2018). Axon Guidance Pathways and the Control of Gene Expression. Developmental Dynamics
2017
Hernandez-Fleming, M., Rohrbach, E. and Bashaw, G.J. (2017). Sema-1a reverse signaling promotes midline crossing in response to secreted Semaphorins. Cell Reports 18(1):174-184.
Santiago, C. and Bashaw, G.J. (2017). Islet coordinately regulates motor axon guidance and dendrite targeting through the Frazzled/DCC receptor. Cell Reports 18 (7): 1646-1659.
2015
Evans, T.A., Santiago, C., Arbeille, E. and Bashaw, G.J. (2015) Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons. eLife eLife Sciences, (doi: 10.7554/eLife.08407).
Chance, R.K. and Bashaw, G.J. (2015) Slit-dependent endocytic trafficking of the Robo receptor is required for Son of Sevenless recruitment and midline axon repulsion. PLoS Genetics 11(9):e1005402. doi: 10.1371/journal.pgen.1005402.
Neuhaus-Follini, A. and Bashaw, G.J. (2015) The intracellular domain of the Frazzled/DCC receptor is a transcription factor required for commissural axon guidance. Neuron 87 (4): 751-763.
Neuhaus-Follini, A. and Bashaw, G.J. (2015) Crossing the embryonic midline: molecular mechanisms regulating axon responsiveness at an intermediate target. Wiley Interdiscip Rev Dev Biol. Wiley Periodicals, Page: 1-13.
2014
Zarin, A., Asadzadeh, J., Hokamp, K., McCartney, D., Yang, L., Bashaw, G.J. and Labrador, J.P. (2014). Combinatorial expression of adhesive, repulsive and attractive guidance molecules dictates motor axon pathway selection downstream of the even-skipped homeodomain transcription factor. Neuron 81 (6): 1297-311.
Santiago, C., Labrador, J.P., and Bashaw, G.J. (2014). The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors. Cell Reports 7 (1): 153-165.
Santiago, C. and Bashaw, G.J. (2014): Transcription factors and effectors that regulate neuronal morphology. Development 141(24):4667-80. doi: 10.1242/dev.110817.
2013
O’Donnell, M., and Bashaw, G.J. (2013). Src Inhibits Midline Axon Crossing Independent of Frazzled/DCC Receptor Tyrosine Phosphorylation. Journal of Neuroscience 33(1):305-14.
O’Donnell, M., and Bashaw, G.J. (2013). Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits. Development 140(13):2724-33.
2012
Evans, T.A. and Bashaw, G.J. (2012). Slit/Robo-mediated axon guidance in Tribolium and Drosophila: Divergent genetic programs build insect nervous systems. Developmental Biology 363: 266-278.
2010
Coleman, H.A., Labrador, J.P., Chance, R.K. and Bashaw, G.J. (2010). The Adam family metalloprotease Kuzbanian regulates the cleavage of the Roundabout receptor to control axon repulsion at the midline. Development 137(14): 2417-26.
Evans, T.A. and Bashaw, G.J. (2010). Functional Diversity of Robo Receptor Immunoglobulin Domains Promotes Distinct Axon Guidance Decisions. Current Biology 20(6), 567-57.
Evans, T.A. and Bashaw, G.J. (2010). Axon Guidance at the Midline: Of Mice and Flies. Current Opinion in Neurobiology 20(1): 79-85.
Bashaw, G.J. and Klein, R. (2010). Signaling from axon guidance receptors. Cold Spring Harbor perspectives in biology. Cold Spring Harbor Press, 2(5): a001941, 1-17.
Bashaw, G.J. (2010). Visualizing axons in the Drosophila central nervous system using immunohistochemistry and immunofluorescence. Cold Spring Harbor protocols pdb.prot, 5503.
Bashaw, G.J. (2010). Live dissection and surface labeling of proteins in Drosophila embryos. Cold Spring Harbor protocols pdb.prot, 5504.
2009
Yang, L, Garbe, D.S. and Bashaw, G.J. (2009). A Frazzled/DCC Dependent Transcriptional Switch Regulates Midline Axon Guidance. Science 15;324 (5929): 944-7.
O’Donnell, M., Chance, R.K. and Bashaw, G.J.(2009) Axon growth and guidance: receptor regulation and signal transduction. Annual review of neuroscience 32: 383-412.
2007
Garbe, D.S., Das, A., Dubreuil, R.R. and Bashaw, G.J. (2007) Beta spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS. Development 134: 273-284.
Garbe, D.S. and Bashaw, G.J. (2007). Independent Functions of Slit-Robo Repulsion and Netrin-Frazzled Attraction Regulate Axon Crossing at the Midline in Drosophila. Journal of Neuroscience 27 (13), 3584-3592.
Garbe, D.S., O’Donnell, M., and Bashaw, G.J. (2007). Cytoplasmic Domain Requirements for Frazzled-mediated Attractive Axon Turning at the Drosophila Midline. Development 134:4315-4324.
Bashaw, G.J. (2007). Semaphorin Directs Axon Traffic in the Fly Olfactory System. Neuron 53(2): 157-159.
2006
Yang, L and Bashaw, G.J. (2006). Son of Sevenless directly links the Robo receptor to Rac activation to control axon repulsion at the midline. Neuron, 52, 595-607.
2005
Labrador, J.P., O’Keefe, D., Yoshikawa, S., McKinnon, R.D., Thomas, J.B. and Bashaw, G.J. (2005). The Homeobox Transcription Factor Even-skipped Regulates Netrin-Receptor Expression to Control Dorsal Motor-Axon Projections in Drosophila. Current Biology 15, 1413-1419.
Hu, H., Li, M., Labrador, J.P., McEwen, J., Lai, E.C., Goodman, C.S. and Bashaw, G.J. (2005) Cross GAP/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. PNAS 102: 4613-4618.
2004
Bashaw, G.J. (2004) Semaphorin signaling unplugged: A nervy AKAP cAMP(s) out on Plexin. Neuron 42(3): 363-366.
Garbe, D.S. and Bashaw, G.J.(2004) Axon guidance at the midline: from mutants to mechanisms. Critical Reviews in Biochemistry and Molecular Biology 39: 319-341.
2003
Fan, X., Labrador, J.P., Hing, H. and Bashaw, G.J. (2003) Slit Stimulation Recruits Dock and Pak to the Roundabout Receptor and Increases Rac Activity to Regulate Axon Repulsion at the CNS Midline. Neuron 40, 113-127.
2002
Godenschwege, T.A., Simpson, J.H., Shan, X., Bashaw, G.J., Goodman, C.S. and Murphey, R.K. (2002) Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity. Journal of Neuroscience 22(8): 3117-3129.
2001
Bashaw, G.J., Hu H., Nobes C.D. and Goodman, C.S. (2001) A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion. Journal of Cell Biology (Cover) 155(7): 1117-1122.
2000
Bashaw, G.J., Kidd, T., Murray, D., Pawson T. and Goodman, C.S. (2000) Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the Roundabout receptor. Cell 101(7): 703-715.
1999
Bashaw, G.J. and Goodman, C.S. (1999) Chimeric axon guidance receptors: the cytoplasmic domains of Slit and Netrin receptors specify attraction versus repulsion. Cell 97(7): 917-926.
1997
Bashaw, G.J. and Baker, B.S. (1997) The regulation of the Drosophila msl-2 gene reveals a function for Sex-lethal in translational control. Cell 89(5): 789-798.
1996
Franke, A., Dernburg, A., Bashaw, G.J. and Baker, B.S. (1996) Evidence that MSL mediated dosage compensation in Drosophila begins at blastoderm. Development 122(9): 2751-2760.
Marin, I., Franke A., Bashaw, G.J. and Baker, B.S. (1996) The dosage compensation system of Drosophila is co-opted by newly evolved X chromosomes. Nature 383(6596): 160-163.
Bashaw, G.J. and Baker, B.S. (1996) Dosage compensation and chromatin structure in Drosophila. Current Opinion in Genetics & Development 6(4): 496-501.
1995
Bashaw, G.J. and Baker, B.S. (1995) The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal. Development 121(10): 3245-3258.