Perelman School of Medicine at the University of Pennsylvania

Biedermann Lab for Orthopaedic Research

Michael Hast, Ph.D.

Assistant Research Professor of Orthopaedic Surgery
Director, Biedermann Lab for Orthopaedic Surgery

Education: Ph.D. Mechanical Engineering, 2011, Pennsylvania State University 

M.S. Mechanical Engineering, 2007, Pennsylvania State University 
B.S. Mechanical Engineering, 2004, Pennsylvania State University

Areas of Special Interest: Biomechanics and Performance of Orthopaedic Implants (Computational Modeling, Contact Forces, Implant Design), Biomechanics of Orthopaedic Injury, Biomechanics of Tendon Healing

Peer-Reviewed Publications:

Gittings DJ, Fryhofer GW, Hast MW, Steinberg DR, Levin LS, Gray BL. The Saline Load Test is Effective at Diagnosing Traumatic Arthrotomies of the Wrist. Tech Hand Up Extrem Surg. 2019 Jan 22. doi: 10.1097/BTH.0000000000000233. [Epub ahead of print] PubMed PMID: 30676429.

Cheema AN, Dardas AZ, Hast MW, Gray BL. The effects of incremental ulnar styloid osteotomies on distal radioulnar joint stability: a biomechanical cadaveric study. J Hand Surg Eur Vol. 2019 Mar 14:1753193419834858. doi:10.1177/1753193419834858. [Epub ahead of print] PubMed PMID: 30871405.

Schmidt EC, Chin M, Aoyama JT, Ganley TJ, Shea KG, Hast MW. Mechanical and Microstructural Properties of Native Pediatric Posterior Cruciate and Collateral Ligaments. Orthop J Sports Med. 2019 Feb 4;7(2):2325967118824400. doi: 10.1177/2325967118824400. eCollection 2019 Feb. PubMed PMID: 30775386; PubMed Central PMCID: PMC6362518.

Bachner EM, Schmidt EC, Chin M, Namdari S, Baxter JR, Hast MW. Parameterization of proximal humerus locking plate impingement with in vitro, in silico, and in vivo techniques. J Shoulder Elbow Surg. 2019 Feb 13. pii: S1058-2746(18)30892-9. doi: 10.1016/j.jse.2018.11.062. [Epub ahead of print] PubMed PMID: 30770316.

Soltero-Rivera M, Elliott MI, Hast MW, Shetye SS, Castejon-Gonzalez AC, Villamizar-Martinez LA, Stefanovski D, Reiter AM. Fracture Limits of Maxillary Fourth Premolar Teeth in Domestic Dogs Under Applied Forces. Front Vet Sci. 2019 Jan 30;5:339. doi: 10.3389/fvets.2018.00339. eCollection 2018. PubMed PMID: 30761310; PubMed Central PMCID: PMC6364561.

Baxter JR, Farber DC, Hast MW. Plantarflexor fiber and tendon slack length are strong determinates of simulated single-leg heel raise height. J Biomech. 2019 Mar 27;86:27-33. doi: 10.1016/j.jbiomech.2019.01.035. Epub 2019 Jan 29. PubMed PMID: 30722935.

Schmidt EC, Chin M, Aoyama JT, Ganley TJ, Shea KG, Hast MW. Mechanical and Microstructural Properties of Pediatric Anterior Cruciate Ligaments and Autograft Tendons Used for Reconstruction. Orthop J Sports Med. 2019 Jan 23;7(1):2325967118821667. doi: 10.1177/2325967118821667. eCollection 2019 Jan. PubMed PMID: 30719479; PubMed Central PMCID: PMC6348523.

Hast MW, Hanson BG, Baxter JR. Simulating contact using the elastic foundation algorithm in OpenSim. J Biomech. 2018 Nov 22. pii: S0021-9290(18)30860-1. doi: 10.1016/j.jbiomech.2018.11.025. [Epub ahead of print] PubMed PMID: 30501910.  

Mehta S, Chin M, Sanville J, Namdari S, Hast MW. Use of an Additional Nonlocking Screw in Olecranon Fracture Osteosynthesis Changes Failure Mechanism.  Orthopedics. 2018 Nov 26:1-7. doi: 10.3928/01477447-20181120-01. [Epub ahead of print] PubMed PMID: 30484851.  

Baxter JR, Hast MW. Plantarflexor metabolics are sensitive to resting ankle angle and optimal fiber length in computational simulations of gait. Gait Posture. 2019 Jan;67:194-200. doi: 10.1016/j.gaitpost.2018.10.014. Epub 2018 Oct  17. PubMed PMID: 30366212.  

Zhang K, Hast MW, Izumi S, Usami Y, Shetye S, Akabudike N, Philp NJ, Iwamoto M, Nissim I, Soslowsky LJ, Enomoto-Iwamoto M. Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing. Am J Sports Med. 2018 Jul;46(9):2222-2231. doi: 10.1177/0363546518778789. Epub 2018 Jun 21. PubMed PMID: 29927623.   

Hast MW, Schmidt EC, Kelly JD 4th, Baxter JR. Computational optimization of graft tension in simulated superior capsule reconstructions. J Orthop Res. 2018 Oct;36(10):2789-2796. doi: 10.1002/jor.24050. Epub 2018 Jun 13. PubMed PMID: 29761555.  

Hast MW, Piazza SJ. Position of the quadriceps actuator influences knee loads  during simulated squat testing. J Biomech. 2018 May 17;73:227-232. doi: 10.1016/j.jbiomech.2018.03.024. Epub 2018 Mar 17. PubMed PMID: 29576314.  

Mehta S, Chin M, Sanville J, Namdari S, Hast MW. Calcar screw position inproximal humerus fracture fixation: Don't miss high! Injury. 2018 Feb 11. pii:S0020-1383(18)30063-9. doi: 10.1016/j.injury.2018.02.007. [Epub ahead of print] PubMed PMID: 29452734.

Schoch B, Hast MW, Mehta S, Namdari S. Not All Polyaxial Locking ScrewTechnologies Are Created Equal: A Systematic Review of the Literature. JBJS Rev. 2018 Jan;6(1):e6. doi: 10.2106/JBJS.RVW.17.00049. PubMed PMID: 29360670.

Rozell JC, Chin M, Donegan DJ, Hast MW. Biomechanical Comparison of FullyThreaded Solid Cortical Versus Partially Threaded Cannulated Cancellous ScrewFixation for Lisfranc Injuries. Orthopedics. 2018 Jan 8:1-6. doi:10.3928/01477447-20180103-03. [Epub ahead of print] PubMed PMID: 29309714.

Mehta S, Tyler A, Hast MW: Understanding the Basics of Computational Modeling in Orthopaedics: A Non-numerical Review for Surgeons. Journal of the American Academy of Orthopaedic Surgeons. 25(10), October 2017.

Rajapakse CS, Kobe EA, Batzdorf AS, Hast MW, Wehrli FW. Accuracy of MRI-based finite element assessment of distal tibia compared to mechanical testing.  Bone. 2017 Dec 24;108:71-78. doi: 10.1016/j.bone.2017.12.023.

Namdari S, Mehta S, Tierney A, Hast MW. Locking Cap Designs Improve Fatigue Properties of Polyaxial Screws in Upper Extremity Applications.  J Orthop Trauma. 2017 May;31(5):275-280. doi: 10.1097/BOT.0000000000000780.

Pulos N, Yoon RS, Shetye S, Hast MW, Liporace F, Donegan DJ.  Anteroinferior 2.7-mm versus 3.5-mm plating of the clavicle: A biomechanical study.  Injury 2016 Jun 3. pii: S0020-1383(16)30220-0. doi: 10.1016/j.injury.2016.06.002.

Freedman BR, Gordon JA, Bhatt PB, Pardes AM, Thomas SJ, Sarver JJ, Riggin CN, Tucker JJ, Williams AW, Zanes RC, Hast MW, Farber DC, Silbernagel KG, Soslowsky LJ.  Nonsurgical treatment and early return to activity leads to improved Achilles tendon fatigue mechanics and functional outcomes during early healing in an animal model.  J Ortho Res2016 Apr 2. doi: 10.1002/jor.23253. 

Jacobs IN, Redden RA, Goldberg R, Hast M, Salowe R, Mauck RL, Doolin EJ. Pediatric laryngotracheal reconstruction with tissue-engineered cartilage in a rabbit model. Laryngoscope. 2016 Jan;126 Suppl 1:S5-S21.

Zhang K, Asai S, Hast MW, Liu M, Usami Y, Iwamoto M, Soslowsky LJ, Enomoto-Iwamoto M.  Tendon Mineralization Is Progressive and Associated with Deterioration of Tendon Biomechanical Properties, and Requires BMP-Smad Signaling in the Mouse Achilles Tendon Injury Model.  Matrix Biology 2016 (Accepted for publication).

Rooney SI, Loro E, Sarver JJ, Peltz CD, Hast MW, Tseng WJ, Kuntz AF, Liu XS, Khurana TS, Soslowsky LJ.  Exercise protocol induces muscle, tendon, and bone adaptations in the rat shoulder. J. Muscles Ligaments Tendons 2015 4(4):413-419.

Hast MW, Abboud JA, Soslowsky LJ.  Exploring the role of hypercholesterolemia in tendon health and repair. J. Muscles Ligaments Tendons 2014 4(3): 275-279. 

Hast MW, Zuskov A, Soslowsky LJ. The role of animal models in tendon research. Bone Joint Res 2014 3(6): 193-202.

Hast MW, Piazza SJ. Dual-Joint Modeling for Estimation of Total Knee Replacement Contact Forces During Locomotion. J Biomech Eng 135 (2013): 021004.

Thompson JA, Hast MW, Granger JF, Piazza SJ, Siston RA. The Biomechanical Effects of Total Knee Arthroplasty Component Malrotation: A Computer Simulation. J Orthop Res 29.7 (2011):969-975.

Landon RL, Hast MW, Piazza SJ. Robust Contact Modeling Using Trimmed NURBS Surfaces for Dynamic Simulations of Articular Contact. Comp Meth in App. Mech & Eng 198330 (2009):2339-2346.

Theses:
Hast MW: Assessment of Total Knee Replacement Performance Using Muscle-Driven Dynamic Simulations, Doctoral Dissertation in Mechanical Engineering, Pennsylvania State University, 2011.

Hast MW: Analysis of Total Knee Replacement Mechanics Using Dynamic Computer Simulations of Controlled Knee Flexions, Master's Thesis in Mechanical Engineering, Pennsylvania State University, 2007.

Conference Papers and Abstracts:

Hast MW, Chin M, Cresap A, Schmidt EC, Kuntz AF: Role of the Central Screw in Glenoid Baseplate Fixation Transactions of the American Society of Biomechanics, August 2018. (Podium Presentation)

Schmidt EC, Ganley TJ, Shea KG, Hast MW: Mechanical Properties of Pediatric ACLs and Tendons Used for Reconstruction. Transactions of the American Society of Biomechanics, August 2018. (Podium Presentation)

Hast MW: How Stiff Should the Construct Be?, Annual Meeting of the Orthopaedic Trauma Association, October 2018. (Podium Presentation)

Mehta S, Chin M, Namdari S, Hast MW: Calcar Screw Position in Proximal Humerus Fracture Fixation: Don't Miss High, Annual Meeting of the Orthopaedic Trauma Association, October 2018. (Podium Presentation)

Schmidt EC, Chin M, Aoyama JT, Ganley TJ, Shea KG, Hast MW: Characterization of Mechanical and Microstructural Properties of Pediatric Anterior Cruciate Ligaments and the Tendons used for Reconstruction. Transactions of the American Academy of Pediatrics November 2018 Notes: (Podium Presentation; Young Investigator Award)

Gittings DJ, Fryhofer G, Hast MW, Gray B: The Saline Load Test is Effective in Detecting Traumatic Arthrotomies of the Wrist. Transactions of the American Society for Surgery of the Hand 73, September 2018.

Kargilis DC, Cheng G, Lee JS, Farid AR, Shetye SS, Hast MW, Jones BC, Rajapakse CS: MRI-Based Assessment of Proximal Femur Compared to Direct Mechanical Testing. Transactions of the American Society of Bone and Mineral Research September 2018.

Stoeckl BD, Hast MW, Sennett ML, Kim M, Eby MR, Schaer TP, Mauck RL, Steinberg DR: The Porcine Accessory Carpal as a Model for Biologic Joint Replacement for Trapeziometacarpal Osteoarthritis  Transactions of the Orthopaedic Research Society 2018.

Rozell JC, Chin M, Donegan DJ, Hast MW: Biomechanical Assessment of Two Unique Screw Designs in Simulated Lisfranc Reconstructions. Transactions of the Orthopaedic Research Society 2018.

Mehta S, Chin M, Sanville J, Namdari S, Hast MW: Additional Screw Use in Olecranon Fracture Reconstruction Changes Failure Mode During Fatigue Testing  Transactions of the Orthopaedic Research Society 2018.

Mehta S, Chin M, Sanville J, Namdari S, Hast MW: Reconstructing Proximal Humerus Fractures with Locking Plates: Don't Miss High? Transactions of the Orthopaedic Research Society 2018.

Hast MW, Schmidt E, Kelley JD IV, Baxter JR: Identifying High Risk Activities after Superior Capsular Reconstruction with a Novel Multidisciplinary Model  Transactions of the Orthopaedic Research Society 2018.

Gittings DJ, Dattilo JR, Fryhofer GW, Hast MW, Mehta S: The Saline Load Test is Effective in Detecting Traumatic Arthrotomies of the Shoulder  Transactions of the Orthopaedic Research Society 2018.

Baxter JR, Bernstein J, Hast MW: A Framework for Optimizing Hip Replacement Positioning Using Measurements of Subject-Specific Motions  Transactions of the Orthopaedic Research Society 2018.

Simi A, Chin M, Kelly JD, Baxter J, and Hast MW: Preliminary Biomechanical Analysis of Superior Capsular Reconstruction Grafts  Proceedings of the American Society of Biomechanics August 2017.

Krach MR, Hast MW, Baxter JR: Joint Contact is Sensitive to Geometry Coarseness and Stiffness in OpenSim. Proceedings of the American Society of Biomechanics August 2017.

Padalkar MV, Shetye SS, Hast MW, Soslowsky LJ, Pleshko N. NIR Spectroscopic Assessment of Ligament Composition Provides Insight into Regional Differences in Mechanical Properties. Trans Orthop Res Soc 41:118, 2016. (Podium Presentation)

Enomoto-Iwamoto M, Zhang K, Hast MW, Cantley L, Iwamoto M, Soslowsky LJ.  Injured Tendons Increase Lactate Synthesis and Pharmacological Inhibition of Lactate Synthesis Improves Tendon Repair. Trans Orthop Res Soc 41:148, 2016. (Podium Presentation)

Freedman BR, Gordon JA, Thomas SJ, Bhatt PB, Riggin CN, Sarver JJ, Tucker JJ, Zanes R, Pardes A, Lee DY, Hast MW, Soslowsky LJ.  Multidisciplinary Evaluation of Treatments for Achilles Tendon Ruptures During Early Healing in an Animal Model. Trans Orthop Res Soc 40:1340, 2015.

Zhang K, Hast MW, Soslowsky LJ , Enomoto-Iwamoto M.  Tendon Mineralization Is Progressive And Detrimental To Tendon Biomechanical Properties. Trans Orthop Res Soc 40:1989, 2015. (Podium Presentation)

Trubelja A, Freedman BR, MacArthur JW, Hast MW, Sarver JJ, Cohen JE, Hiesinger W, Atluri P, Woo YJ.  Effects of Engineering SDF-1a on Infarcted Myocardium Under Dynamic Loading Conditions. Biomedical Engineering Society Annual Meeting, San Antonio, TX, October 2014.

Hast MW, Zuskov A, Weibel J, Schweitzer R, Soslowsky LJ. Mechanical Properties and Fiber Alignment of Postnatal Mouse Supraspinatus Tendons in Mohawk Knockout Mice. World Congress of Biomechanics, Boston MA, July 2014.

Hast MW, Yannascoli S, Fryhofer GW, Tseng WJ, Altman AR, Liu XS, Soslowsky LJ. Overuse Following a Large Rotator Cuff Tear Alters Trabecular Bone Architecture, but Not Glenoid Curvature in a Rat Model. Trans Orthop Res Soc 39:132, 2014. Podium Presentation

Rooney SI, Loro E, Sarver JJ, Peltz CD, Hast MW, Tseng W-J, Liu XS, Khurana TS, Soslowsky LJ. Exercise Protocol Induces Muscle, Tendon, and Bone Adaptations in the Rat Shoulder. Trans Orthop Res Soc 39:1898, 2014.

Driscoll TP, Chang J, Keyes TS, Hast MW, Heo SJ, Mauck RL, Chao PG.  Engineered Fiber Crimp Alters Scaffold Mechanics, Cell Shape, and Strain Transfer to the Nucleus. Trans Orthop Res Soc 39:502, 2014. 

Hast MW, Piazza SJ. Dual-Joint Modeling for the Estimation of Total Knee Replacement Contact Forces During Locomotion, American Society of Mechanical Engineers Summer Bioengineering Conference, Nemacolin Woods, PA. June, 2011. Podium Presentation

Hast MW, Piazza SJ. Position of the Quadriceps Muscle Actuator Influences Knee Loads During Simulated Squat Testing. American Society of Biomechanics, Providence, RI. August, 2010. Podium Presentation

Hast MW, Walker CD, Piazza SJ. PCL Treatment Influences Sensitivity to Joint Line Changes in Total Knee Arthroplasty. Transactions of the American Society of Biomechanics, University Park, PA. August, 2009.

Hast MW, Walker CD, Piazza SJ. Management of Flexion-Extension Gap Inequality in TKA: A Computer Simulation Study. Trans Orthop Res Soc 34:2091, 2009.

Hast MW, Landon RL, Piazza SJ. Influence of Posterior Cruciate Ligament Treatment on Quadriceps Demand in TKR: A Computer Simulation Study. Transactions of the North American Congress of Biomechanics, Ann Arbor, MI. August 2008. Podium Presentation

Hast MW, Landon RL, Piazza SJ. Influence of Loading on Knee Extensor Mechanics in Total Knee Replacement: A Computer Simulation Study. Transactions of the American Society of Biomechanics, Palo Alto, CA. August, 2007.

Awards:
First Place: American Society of Mechanical Engineers Grand Challenge to Predict In Vivo Knee Loads, 2011

Second Place: Penn State Mechanical Engineering Department Senior Design Project Competition, 2004

Eastern Orthopaedic Association's Resident/Fellow Paper Award, 2017

Young Investigator Award, American Academy of Pediatrics, 2018

Eagle Scout: Boy Scouts of America