Lewis A. Chodosh, M.D., Ph.D.
Perelman Professor and Chair
Associate Director for Basic Science, Abramson Cancer Center
Co-Director, 2-PREVENT Translational Center of Excellence
Investigator, Abramson Family Cancer Research Institute
Contact Information
421 Curie Boulevard, 614 BRB II/III
Philadelphia PA, 19104-6160
T: (215) 898-1321 F: (215) 573-6725
Email: chodosh@pennmedicine.upenn.edu
Education
B.S. (Molecular Biophysics & Biochemistry) Yale University, 1981
Ph.D. (Biochemistry)Massachusetts Institute of Technology, 1988
M.D. Harvard Medical School, 1989
Current Research
The Chodosh laboratory uses genetically engineered mouse models, patient samples and bioinformatics to understand the mechanisms by which cancers develop, progress to more aggressive states, and ultimately contribute to cancer mortality. A broad array of basic and translational research approaches are used to address problems of fundamental clinical importance to cancer patients by elucidating pathways and principles common to human cancers. These approaches encompass genetics, genomics, molecular biology, biochemistry, cell biology, computational biology, functional imaging, animal studies, preclinical trials and clinical investigation. Particular areas of interest include: pathways regulating cancer development, metastasis, tumor dormancy and recurrence; the use of genomics and computational approaches to understand genetic programs in cancer; the impact of obesity on cancer recurrence; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches to study tumor biology.
Contact:
Chodosh Laboratory
Department of Cancer Biology
421 Curie Boulevard, 627 BRB II/III
Philadelphia, PA 19104-6160
T: (215) 898-0006 F: (215) 573-6725
Lab Manager:
Jennifer McCallum
Jennifer.McCallum@pennmedicine.upenn.edu
215-898-0275
Assistant Director, Administrative and Faculty Affairs:
Katelyn Carlin
kwichert@upenn.edu
215-746-5031
Selected Publications
01. Abravanel DL, Belka GK, Pan TC, Pant DK, Collins MA, Sterner CJ and Chodosh LA. Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy. Journal of Clinical Investigation, 2484-2496, 2015.
02. Alvarez JV, Belka GK, Pan TC, Chen CC, Blankemeyer E, Alavi A, Karp JS and Chodosh LA. Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. Cancer Research, 74: 7583-7598, 2014.
03. Feng Y, Pan TC, Pant DK, Chakrabarti KR, Alvarez JV, Ruth JR and Chodosh LA. SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Cancer Discovery, 790-803, 2014.
04. Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou AY, Pant D, Grimley JS, Wandless TJ, DeMichele A, I-SPY 1 Trial Investigators and Chodosh LA. Par-4 down-regulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell, 24:30-44, 2013.
05. Yeh ES, Belka GK, Vernon AE, Chen CC, Jung JJ and Chodosh LA. Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. PNAS, 110:6103-8, 2013.
06. Chen CC, Stairs DB, Boxer RB, Belka GK, Horseman ND, Alvarez JV and Chodosh LA. Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes & Development, 26:2154-2168, 2012
07. Wertheim GBW, Yang TW, Pan TC, Ramne A, Liu Z, Gardner HP, Dugan KD, Kristel P, Kreike B, Vijver MJ, Cardiff RD and Chodosh LA. The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. PNAS, 106:15855-60, 2009.
08. Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE and Chodosh LA. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nature Cell Biology, 9:493-505, 2007.
09. Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portacarrero CP, Keister BA, Belka GK, Cho H, Rathmell J, Thompson CB, Birnbaum MJ and Chodosh LA. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metabolism, 4:475-490, 2006.
10. Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero C, Sterner CJ, Notorfrancesco K, Cardiff RD and Chodosh LA. The transcriptional repressor, Snail, promotes mammary tumor recurrence. Cancer Cell 8:197-209, 2005.
Lab Personnel
Katelyn Carlin - Assistant Director, Administrative and Faculty Affairs kwichert@upenn.edu
Jennifer McCallum - Lab Manager Jennifer.McCallum@pennmedicine.upenn.edu
Adetutu Egunsola - Postdoctoral Researcher
Amulya Sreekumar - Postdoctoral Researcher
Beth Chislock - Postdoctoral Researcher
Brian Benz - Graduate Student
Chris Sterner - Project Manager
Dhruv Pant - Computational Biologist
Francesco Marino - Postdoctoral Researcher
George Belka - Research Project Manager
George Woodfield - Research Specialist
Heather Martin - Sr. Research Invstigator
Jewell Graves - Research Specialist
Jianping Wang - Research Specialist
Julie Castro - Research Specialist
Katherine Huang - Graduate Student
Kyra Harvey - Research Specialist
Matias Escobar-Aguirre - Postdoctoral Researcher
Matt Paul - Graduate Student
Nathan Mears - Lab Animal Tech
Tien-chi Pan - Computational Biologist
Tristan Shi - Graduate Student
Yan Chen - Research Specialist