Center for Brain Imaging and Stimulation

Welcome to the Center for Brain Imaging and Stimulation homepage at the University of Pennsylvania. We are also affiliated with the Center for Neuromodulation in Depression and Stress, Department of Psychiatry, Perelman School of Medicine as well as the Departments of Neuroscience, Neurosurgery, Neurology, Bioengineering, the brainSTIM Center and the Institute for Translational Medicine and Therapeutics.

Center Mission Statement

The goal of the center is to leverage cutting edge neuroimaging to guide brain stimulation for interrogating and manipulating brain networks, especially those involved in neuropsychiatric conditions. We also pursue TMS/fMRI methods development research with broad applications to cognitive and affective systems.


To define causal communication pathways and to quantify neural circuit integrity, our group interleaves single-pulse Transcranial Magnetic Stimulation (TMS) with functional MRI recordings (TMS/fMRI). We benefit from the slow rise time of the BOLD response to interleave TMS pulses and to capture the resulting brain activity caused by TMS to the surface of the brain.

We also use structural and functional MRI to guide efforts to influence behavior, cognitive function, psychophysiological responses, and symptoms, especially in depression and post-traumatic stress with repetitive trains of TMS (rTMS).

Targeted Behaviors and Symptoms

Our current projects are designed to improve worry/rumination symptoms, working memory, and mentalizing functions including through the use of resting fMRI, diffusion imaging, network control theory, neuroeconomics, and closed-loop TMS/fMRI.




brain 3d render

The BRAIN Initiative    National Institute of Mental Health  Brain & Behavior Research Foundation - Awarding Narsad GrantsCure Accelerator  AE Foundation // Hart Fund

MindCORE DivE In (Diversity and Equity Initiative)

CBIS is a proud participant in this annual event featuring presentations, workshops and panels designed to prepare students for success in graduate school. 

D.Oathes at DivE In