Participate in our Research Studies

Individualized (fMRI-Guided) TMS Treatment for Depression

The purpose of this study is to investigate brain responses to transcranial magnetic stimulation (TMS) in individuals diagnosed with depression. To achieve this, we will combine Magnetic Resonance Imaging (MRI) techniques with TMS to explore the relationship between activity in a specific brain region and TMS stimulation before, during, and after a full TMS treatment intervention.

Study participation will include completing various questionnaires, clinical assessments, receiving a full transcranial magnetic stimulation (TMS) treatment intervention (every weekday for 6 weeks), and undergoing MRI scans, both with and without concurrent TMS. In-person participation will last for approximately 10 weeks, but there may be possible delays (~2-3 weeks) due to scheduling availability, MRI scanner availability, or other unforeseen circumstances. In addition, participants will be asked to complete remote follow-up assessments at 1, 6, and 12 months post-TMS treatment.

If you are interested in participating, please contact Camilla Whitesel at camilla.whitesel@pennmedicine.upenn.edu or 215-573-0828.

For detailed information about the study, please visit:  https://clinicaltrials.gov/study/NCT06266390

Patient testimonial from the above rTMS treatment study:

"I am so grateful to have participated in the TMS clinical trial with the Oathes Lab. Before the study, I felt hopeless - after trying countless treatments for my depression, nothing seemed to help. But the Oathes Lab team was kind, culturally attuned, and knowledgeable. They took time to explain the non-invasive TMS treatment and made me feel safe and supported every step of the way. The treatment itself was surprisingly effective. By the end of the 6-week study, I experienced significant improvement in both my depression and anxiety symptoms. Even months later, I continue to feel better, doing things I never thought possible and even finding joy in them! If you, too, are struggling with depression, don’t give up. There is real hope, and this could be the step that changes everything."