Perelman School of Medicine at the University of Pennsylvania

Huang Lab


  1.  ​​​​​Yu Q#, Peng Y#, Kang H, Peng Q, Ouyang M, Slinger M, Hu D, Shou H, Fang F*, Huang H*, 2020. Differential white matter maturation from birth to 8 years of age. Cerebral Cortex 30(4): 2673-2689. [PubMed] (*: co-corresponding author; #: co-first author).

  2. Zheng Q, Shellikeri S, Huang H, Hwang M, Sze R, 2020. Deep Learning Measurement of Leg Length Discrepancy in Children Based on Radiographs. Radiology 296(1):152-158. [PubMed].

  3. Peng Q, Ouyang M, Wang J, Yu Q, Zhao C, Slinger M, Li H, Fan Y, Hong B, Huang H, 2020. Regularized-Ncut: Robust and homogeneous functional parcellation of neonate and adult brain networks. Artificial Intelligence in Medicine 106: 101872. [PubMed]

  4. Kong L, Lv B, Wu T, Zhang J, Fan Y, Ouyang M, Huang H, Peng Y, Liu Y, 2020. Altered structural cerebral cortex in children with Tourette syndrome. European Journal of Radiology 129: 109119. [PubMed]

  5. Zheng Q, Martin-Saavedra JS, Saade-Lemus S, Vossough A, Zuccoli G, Goncalves FG, Freeman CW, Ouyang M, Singh V, Padula MA, Demauro SB, Flibotte J, Eichenwald EC, Detre GA, Sze RW, Huang H, Hwang M, 2020. Cerebral pulsed arterial spin labeling perfusion weighted imaging predicts language and motor outcomes in neonatal hypoxic-ischemic encephalopathy. Frontiers in Pediatrics 8:576489. [PubMed]

  6. Ouyang M, Peng Q, Jeon T, Heyne R, Chalak L, Huang H, 2020. Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds. eLife 2020;9:e58116. [PubMed]
    Ouyang, M, et al., eLife 2020
  7. Ouyang M#, Jeon T#, Sotiras A, Peng Q, Mishra V, Halovanic C, Chen M, Chalak L, Rollins N, Roberts T, Davatzikos C, Huang H, 2019. Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging. Proceedings of the National Academy of Sciences of the United States of America 116(10): 4681-4688.  [PubMed] (#: co-first author)

  8. Ouyang M, Dubois J, Yu Q, Mukherjee P, Huang H, 2019. Delineation of early brain development from fetuses to infants with diffusion MRI and beyond. Neuroimage 185: 836-850. [PubMed]

  9. Oishi K, Chang L, Huang H, 2019. Baby brain atlases and templates. Neuroimage 185: 865-880. [PubMed]

  10. Feng L#, Li H#, Oishi K, Mishra V, Song L, Peng Q, Ouyang M, Wang J, Slinger M, Jeon T, Lee L, Heyne R, Chalak L, Peng Y, Liu S, Huang H, 2019. Age-specific gray and white matter DTI atlas for human brain at 33, 36 and 39 postmenstrual weeks. Neuroimage 185: 685-698. (#: co-first author) [PubMed]

  11. Zhao T#, Mishra V#, Jeon T, Ouyang M, Peng Q, Chalak L, Wisnowski JL, Heyne R, Rollins N, Shu N*, Huang H*, 2019. Structural network maturation of the preterm human brain. Neuroimage 185: 699-710. (*: co-corresponding author; #: co-first author) [PubMed]

  12. Zhang M, Wang S, Hu D, Ouyang M, Zhang Y, Rao B, Huang H, Peng Y. 2019. Altered brain functional network in children with type 1 Gaucher disease: a longitudinal graph theory-based study. Neuroradiology 61(1): 63-70. [PubMed]

  13. Liu P, Parkinson C, Jiang D, Ouyang M, De Vis JB, Northington FJ, Tekes A, Huang H, Huisman TA, Golden WC, 2019. Characterization of MRI techniques to assess neonatal brain oxygenation and blood flow. NMR in Biomedicine. 32(7): e4103. [PubMed]

  14. Lawrence KM, McGovern PE, Mejaddam A, Rossidis AC, Baumgarten H, Kim A, Grinspan JB, Licht DJ, Didier RA, Vossough A, Radaelli E, Rychik J, Song L, Peranteau WH, Davey MG, Flake AW, Gaynor JW, 2019. Chronic intrauterine hypoxia alters neurodevelopment in fetal sheep. The Journal of thoracic and cardiovascular surgery 157(5): 1982-1991. [PubMed]

  15. Xu Y#, Cao M#, Liao X, Xia M, Wang X, Jeon T, Ouyang M, Chalak L, Rollins N, Huang H*, He Y*, 2019. Development and emergence of individual variability in the functional connectivity architecture of the preterm human brain. Cerebral Cortex 29(10):4208-4222. [PubMed] (*: co-corresponding author; #: co-first author).

  16. Huang H, Huppi PS, He Y, Lerch J, 2019. Imaging baby brain development. Neuroimage 203: 116142. [PubMed].

  17. Farahany NA, Greely HT, Hyman S, Koch C, Grady C, Pasca SP, Sestan N, Arlotta P, Bernat JL, Ting J, Lunshof JE, Iyer EPR, Hyun I, Capestany BH, Church GM, Huang H, Song H, 2018. The ethics of experimenting with human brain tissue. Nature 556(7702):429-432.[PubMed]

  18. Kang H, Zhang M, Ouyang M, Guo R, Yu Q, Peng Q, Zhang N, Zhang Y, Duan Y, Tang X, Mishra V, Fang F, Li W, Huang H, Peng Y, 2018. Brain white matter microstructural alterations in children of type I Gaucher disease characterized with diffusion tensor MR imaging. European Journal of Radiology 102: 22-29. [PubMed]

  19. Cao M, He Y, Dai Z, Liao X, Jeon T, Ouyang M, Chalak L, Bi Y, Rollins N, Dong Q, Huang H, 2017. Early development of functional network segregation revealed by connectomic analysis of the preterm human brain. Cerebral Cortex 27(3): 1949-1963. [PubMed]

  20. Ouyang M, Liu P, Jeon T, Chalak L, Heyne R, Rollins NK, Licht DJ, Detre JA, Roberts T, Lu H, Huang H, 2017. Heterogeneous increases of regional cerebral blood flow during preterm brain development: Preliminary assessment with pseudo-continuous arterial spin labeled perfusion MRI. Neuroimage 147: 233-242.[PubMed]

  21. Ouyang M, Kang H, Detre J, Roberts T, Huang H, 2017. Short-range connections in the developmental connectome during typical and atypical brain maturation. Neuroscience & Biobehavioral Reviews 83:109-122. [PubMed]

  22. Hubbard, N.A., Turner, M.P., Ouyang, M., Himes, L., Thomas, B.P., Hutchison, J.L., Faghihahmadabadi, S., Davis, S.L., Strain, J.F., Spence, J., Krawczyk, D.C., Huang, H., Lu, H., Hart, Jr., J., Frohman, T., Frohman, E., Okuda, D.T., Rypma, B., 2017. Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis. Human Brain Mapping 38(11): 5375-5390 [PubMed]

  23. Cao M, Huang H, He Y, 2017. Developmental connectomics from infancy through early childhood. Trends in Neurosciences 40(8):494-506. [PubMed]

  24. Feng L, Jeon T, Yu Q, Ouyang M, Peng Q, Mishra V, Pletikos M, Sestan N, Miller MI, Mori S, Hsiao S, Liu S, Huang H, 2017. Population-averaged atlas with high-resolution ex vivo DTI integrated into in vivo space. Brain Structure and Function, 222(9), 4131-4147. [PubMed]

  25. Krsnik Ž, Majić V, Vasung L, Huang H, Kostović I, 2017. Growth of thalamocortical fibers to the somatosensory cortex in the human fetal brain. Frontiers in Neuroscience 11: 233. [PubMed]

  26. Song L, Mishra V, Ouyang M, Peng Q, Slinger M, Liu S, Huang H, 2017. Human fetal brain connectome: structural network development from middle fetal stage to birth. Frontiers in Neuroscience 11:561. [PubMed]

  27. Hubbard NA, Sanchez Araujo Y, Caballero C, Ouyang M, Turner MP, Himes L, Faghihahmadabadi S, Thomas BP, Hart J, Jr., Huang H, Okuda DT, Rypma B, 2017. Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis. Brain Sciences 7(6): 64. [PubMed]

  28. Yu Q, Ouyang A, Chalak L, Jeon T, Chia J, Mishra V, Sivarajan M, Jackson G, Rollins N, Liu S, Huang H, 2016. Structural development of human fetal and preterm brain cortical plate based on population-averaged templates. Cerebral Cortex 26(11): 4381-4391. [PubMed]

  29. Bauer I, Meyer TD, Mwangi B, Ouyang A, Spiker D, Zunta-Soares GB, Huang H, Soares JC, 2016. The role of white matter in personality traits and affective processing in bipolar disorder. Journal of Psychiatric Research 80:64-72. [PubMed]

  30. Cao M, Huang H, Peng Y, Dong Q, He Y, 2016. Towards developmental connectomics of the human brain. Frontiers in Neuroanatomy 10:25. [PubMed]

  31. Zigler JS Jr, Hodgkinson CA, Wright M, Klise A, Sundin O, Broman KW, Hejtmancik F, Huang H, Patek B, Sergeev Y, Hose S, Brayton C, Xaiodong J, Vasquez D, Maragakis N, Mori S, Goldman D, Hoke A, Sinha D, 2016. A spontaneous missense mutation in branched chain keto acid dehydrogenase kinase in the rat affects both the central and peripheral nervous systems. PLoS One 11(7):e0160447.[PubMed]

  32. Ouyang M, Cheng H, Mishra V, Gong G, Mosconi M, Sweeney J, Peng Y, Huang H, 2016. Atypical age-dependent effects of autism on white matter microstructure in children of 2-7 years. Human Brain Mapping 37(2): 819-832. [PubMed]

  33. Liu P, Chalak L, Krishnamurthy L, Mir I, Peng SL, Huang H, Lu H, 2016. Neonatal T1 and T2 values at 3T: dependence on hematocrit, oxygenation and temperature. Magnetic Resonance in Medicine 75(4): 1730-1735. [PubMed]

  34. Hubbard NA, Hutchison JL, Turner M, Sundaram S, Oasay L, Robinson D, Strain S, Weaver T, Davis S, Remington G, Huang H, Biswal BB, Hart J, Frohman T, Frohman E, Rypma B, 2016. Asynchrony in executive networks predicts cognitive slowing in multiple sclerosis. Neuropsychology 30(1): 75-86. [PubMed]

  35. Hubbard NA, Turner M, Hutchison JL, Ouyang A, Strain J, Oasay L, Sundaram S, Davis S, Remington G, Brigante R, Huang H, Hart J Jr, Frohman T, Frohman E, Biswal BB, Rypma B, 2016. Multiple sclerosis-related white matter microstructural change alters the BOLD hemodynamic response. Journal of Cerebral Blood Flow & Metabolism 36(11):1872-1884. [PubMed]

  36. Wang ZJ, Seo Y, Babcock E, Huang H, Bluml S, Wisnowski J, Holshouser B, Panigrahy A, Shaw DWW, Altman N, McColl RW, Rollins NK, 2016. Assessment of diffusion tensor image quality across sites and vendors using the American College of Radiology head phantom. Journal of Applied Clinical Medical Physics 17(3): 442-451. [PubMed]