Penn PROMOTES Research on Sex and Gender in Health was established in 2012 as the result of a National Institute of Mental Health and Office of Research on Women's Health grant to study mood disorders across the female lifespan. Jointly awarded to Dr. C. Neill Epperson and Dr. Tracy Bale, this grant hopes to improve our understanding of how diseases, and affective disorders in specific, affect men and women differently. Together, Drs. Epperson and Bale hope to shed light on the gender differences in common mental health disorders such as depression, anxiety and somatic complaints. Penn PROMOTES takes an interdisciplinary approach to answering these questions about sex and gender in health, incorporating perspectives from the School of Medicine, School of Veterinary Medicine, School of Arts and Sciences and beyond. Over the past 4 years, Penn PROMOTES has evolved to include 3 programs of research all aiming to unearth many questions and answers about how gender plays a role in health today. Primarily, Penn PROMOTES serves as a virtual Center, incorporating the research of the Penn Center for Women's Behavioral Wellness, the Bale Lab, and the Penn BIRCWH.