View all publications from the Kelz Lab

Labonte AK, Kafashan M, Huels ER, Blain-Moraes S, Basner M, Kelz MB, Mashour GA, Avidan MS, Palanca BJA; ReCCognition Study Group. The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia.  Br J Anaesth. 2022, S0007-0912(22)00028-9. doi: 10.1016/j.bja.2022.01.019. Online ahead of print.


Rokos A, Mišić B, Berkun K, Duclos C, Tarnal V, Janke E, Picton P, Golmirzaie G, Basner M, Avidan MS, Kelz MB, Mashour GA, Blain-Moraes S. Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness. Front Hum Neurosci. 2021, 15:706693.


Cieslak M, Cook PA, He X, Yeh FC, Dhollander T, Adebimpe A, Aguirre GK, Bassett DS, Betzel RF, Bourque J, Cabral LM, Davatzikos C, Detre JA, Earl E, Elliott MA, Fadnavis S, Fair DA, Foran W, Fotiadis P, Garyfallidis E, Giesbrecht B, Gur RC, Gur RE, Kelz MB, Keshavan A, Larsen BS, Luna B, Mackey AP, Milham MP, Oathes DJ, Perrone A, Pines AR, Roalf DR, Richie-Halford A, Rokem A, Sydnor VJ, Tapera TM, Tooley UA, Vettel JM, Yeatman JD, Grafton ST, Satterthwaite TD.  QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data. Nat Methods. 2021; 18(7):775-778.


Duclos C, Maschke C, Mahdid Y, Berkun K, Castanheira JDS, Tarnal V, Picton P, Vanini G, Golmirzaie G, Janke E, Avidan MS, Kelz MB, Liuzzi L, Brookes MJ, Mashour GA, Blain-Moraes S.  Differential classification of states of consciousness using envelope- and phase-based functional connectivity. Neuroimage. 2021; 237:118171.


Mashour GA, Palanca BJ, Basner M, Li D, Wang W, Blain-Moraes S, Lin N, Maier K, Muench M, Tarnal V, Vanini G, Ochroch EA, Hogg R, Schwartz M, Maybrier H, Hardie R, Janke E, Golmirzaie G, Picton P, McKinstry-Wu AR, Avidan MS, Kelz MB. Recovery of consciousness and cognition after general anesthesia in humans. Elife. 2021; 10:e59525.


Reitz SL, Kelz MB.  Preoptic Area Modulation of Arousal in Natural and Drug Induced Unconscious States. Front Neurosci. 2021; 15:644330.


Duclos C, Nadin D, Mahdid Y, Tarnal V, Picton P, Vanini G, Golmirzaie G, Janke E, Avidan MS, Kelz MB, Mashour GA, Blain-Moraes S. Brain network motifs are markers of loss and recovery of consciousness. Sci Rep. 2021; 11(1):3892.


Venincasa MJ, Randlett O, Sumathipala SH, Bindernagel R, Stark MJ, Yan Q, Sloan SA, Buglo E, Meng QC, Engert F, Züchner S, Kelz MB, Syed S, Dallman JE. Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia. Sci Rep. 2021; 11(1):3148.


Ramayya AG, Yang AI, Buch VP, Burke JF, Richardson AG, Brandon C, Stein JM, Davis KA, Chen HI, Proekt A, Kelz MB, Litt B, Gold JI, Lucas TH. Theta Synchrony Is Increased near Neural Populations That Are Active When Initiating Instructed Movement. eNeuro. 2021; 8(1):ENEURO.0252-20.2020.


Reitz SL, Wasilczuk AZ, Beh GH, Proekt A, Kelz MB. Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness. Curr Biol. 2021 Jan 25;31(2):394-405.


Proekt A, Kelz MB. Explaining anaesthetic hysteresis with effect-site equilibration.  Br J Anaesth. 2021; 126(1):265-278


Culley DJ, Kelz MB, Koch CG, Eisenach JC, Neuman MD, Whitlock EL, Robertson RM, Cooper T, Pomerantz P. Creation of the Anesthesia Research Council.  Anesth Analg. 2020; 131(4):1300-1303.


Wasilczuk AZ, Harrison BA, Kwasniewska P, Ku B, Kelz MB, McKinstry-Wu AR, Proekt A. Resistance to state transitions in responsiveness is differentially modulated by different volatile anaesthetics in male mice.  Br J Anaesth. 2020; 125(3):308-320.


McKinstry-Wu AR, Proekt A, Kelz MB. Neural Inertia: A Sticky Situation for Anesthesia.  J Neurosurg Anesthesiol. 2020; 32(3):190-192.


McKinstry-Wu AR, Wasilczuk AZ, Harrison BA, Bedell VM, Sridharan MJ, Breig JJ, Pack M, Kelz MB, Proekt A. Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia. Elife. 2019; 8:e50143.


Kelz MB, Mashour GA. The Biology of General Anesthesia from Paramecium to Primate. Curr Biol. 2019; 29(22):R1199-R1210.


Morgan PG, Kelz MB. Be Wary of Genes Governing Awareness.  Anesthesiology. 2019; 131(5):955-956.


Shortal BP, Hickman LB, Mak-McCully RA, Wang W, Brennan C, Ung H, Litt B, Tarnal V, Janke E, Picton P, Blain-Moraes S, Maybrier HR, Muench MR, Lin N, Avidan MS, Mashour GA, McKinstry-Wu AR, Kelz MB, Palanca BJ, Proekt A; ReCCognition Study Group. Duration of EEG suppression does not predict recovery time or degree of cognitive impairment after general anaesthesia in human volunteers.  Br J Anaesth. 2019; 123(2):206-218.


Hemmings HC Jr, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA. Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery. Trends Pharmacol Sci. 2019 Jul;40(7):464-481.


Aggarwal A, Brennan C, Shortal B, Contreras D, Kelz MB, Proekt A. Coherence of Visual-Evoked Gamma Oscillations Is Disrupted by Propofol but Preserved Under Equipotent Doses of Isoflurane. Front Syst Neurosci. 2019 May 8;13:19.


Li D, Vlisides PE, Kelz MB, Avidan MS, Mashour GA; ReCCognition Study Group. Dynamic Cortical Connectivity during General Anesthesia in Healthy Volunteers. Anesthesiology. 2019; 130(6):870-884.


Kelz MB, García PS, Mashour GA, Solt K. Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia. Anesth Analg. 2019; 128(4):726-736.


Lee H, Golkowski D, Jordan D, Berger S, Ilg R, Lee J, Mashour GA, Lee U; ReCCognition Study Group.  Relationship of critical dynamics, functional connectivity, and states of consciousness in large-scale human brain networks. Neuroimage. 2019; 188:228-238.


Ferreira AL, Correia R, Vide S, Ferreira AD, Kelz MB, Mendes JG, Nunes CS, Amorim P. Patterns of Hysteresis Between Induction and Emergence of Neuroanesthesia Are Present in Spinal and Intracranial Surgeries. J Neurosurg Anesthesiol. 2020; 32(1):82-89.


Palanca BJA, Maybrier HR, Mickle AM, Farber NB, Hogan RE, Trammel ER, Spencer JW, Bohnenkamp DD, Wildes TS, Ching S, Lenze E, Basner M, Kelz MB, Avidan MS. Cognitive and Neurophysiological Recovery Following Electroconvulsive Therapy: A Study Protocol. Front Psychiatry. 2018; 9:171.


Shortal BP, Reitz SL, Aggarwal A, Meng QC, McKinstry-Wu AR, Kelz MB, Proekt A. Development and validation of brain target controlled infusion of propofol in mice. PLoS One. 2018; 13(4):e0194949.


McKinstry-Wu AR, Kelz MB. Optoanesthesia: Use of Anesthetic Photolabels In Vivo. Methods Enzymol. 2018; 603:171-180


McKinstry-Wu A, Carspecken CW, Proekt A, Kelz MB. Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration. Methods Enzymol. 2018; 602:289-298. 


Wasilczuk AZ, Maier KL, Kelz MB. The Mouse as a Model Organism for Assessing Anesthetic Sensitivity. Methods Enzymol. 2018; 602:211-228.


Mashour GA, Kelz MB. Systems Neuroscience: The Exciting Journey to Oblivion. Curr Biol. 2018; 28(5):R223-R224.


Kim H, Hudetz AG, Lee J, Mashour GA, Lee U; ReCCognition Study Group. Estimating the Integrated Information Measure Phi from High-Density Electroencephalography during States of Consciousness in Humans. Front Hum Neurosci. 2018; 12:42.


Blain-Moraes S, Tarnal V, Vanini G, Bel-Behar T, Janke E, Picton P, Golmirzaie G, Palanca BJA, Avidan MS, Kelz MB, Mashour GA. Network Efficiency and Posterior Alpha Patterns Are Markers of Recovery from General Anesthesia: A High-Density Electroencephalography Study in Healthy Volunteers. Front Hum Neurosci. 2017; 11:328.


Richardson AG, Liu X, Weigand PK, Hudgins ED, Stein JM, Das SR, Proekt A, Kelz MB, Zhang M, Van der Spiegel J, Lucas TH. Hippocampal gamma-slow oscillation coupling in macaques during sedation and sleep. Hippocampus. 2017; (11):1125-1139.


Maier KL, McKinstry-Wu AR, Palanca BJA, Tarnal V, Blain-Moraes S, Basner M, Avidan MS, Mashour GA, Kelz MB. Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study. Front Hum Neurosci. 2017;11:284


Wasilczuk AZ, Proekt A, Kelz MB, McKinstry-Wu AR.  High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources. J Vis Exp. 2016; (117):54908.


Erickson RL, Terzi MC, Jaber SM, Hankenson FC, McKinstry-Wu A, Kelz MB, Marx JO.  Intraperitoneal Continuous-Rate Infusion for the Maintenance of Anesthesia in Laboratory Mice (Mus musculus). J Am Assoc Lab Anim Sci. 2016; 55(5):548-57.


Gardner B, Strus E, Meng QC, Coradetti T, Naidoo NN, Kelz MB, Williams JA.  Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol? Anesthesiology. 2016; 124(2):404-16.


Drobish JK, Kelz MB, DiPuppo PM, Cook-Sather SD.  Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. A A Case Rep. 2015; 4(11):148-50.


Jaber SM, Hankenson FC, Heng K, McKinstry-Wu A, Kelz MB, Marx JO.  Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice. J Am Assoc Lab Anim Sci. 2014; 53(6):684-91.


McCarren HS, Chalifoux MR, Han B, Moore JT, Meng QC, Baron-Hionis N, Sedigh-Sarvestani M, Contreras D, Beck SG, Kelz MB.  α2-Adrenergic stimulation of the ventrolateral preoptic nucleus destabilizes the anesthetic state.  J Neurosci. 2014; 34(49):16385-96.


Han B, McCarren HS, O'Neill D, Kelz MB.  Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer. Anesthesiology. 2014; 121(5):999-1009.


McCarren HS, Moore JT, Kelz MB. Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention. J Vis Exp. 2013; (80):e51079.


Deutschman CS, Raj NR, McGuire EO, Kelz MB.  Orexinergic activity modulates altered vital signs and pituitary hormone secretion in experimental sepsis. Crit Care Med. 2013; 41(11):e368-75.


Joiner WJ, Friedman EB, Hung HT, Koh K, Sowcik M, Sehgal A, Kelz MB.  Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.  Genet. 2013; 9(9):e1003605.


Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA. Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. J Neurosci. 2013; 33(17):7264-73


Scharf MT, Kelz MB. Sleep and Anesthesia Interactions: A Pharmacological Appraisal. Curr Anesthesiol Rep. 2013; 3(1):1-9.


Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. Incidence, predictors and outcomes of postoperative coma: an observational study of 858,606 patients. Eur J Anaesthesiol. 2013; 30(8):476-82.


Weiser BP, Kelz MB, Eckenhoff RG. In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets. J Biol Chem. 2013; 288(2):1279-85.


Moore JT, Chen J, Han B, Meng QC, Veasey SC, Beck SG, Kelz MB. Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis. Curr Biol. 2012; 22(21):2008-16.


Hu FY, Hanna GM, Han W, Mardini F, Thomas SA, Wyner AJ, Kelz MB. Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice.  Anesthesiology. 2012; 117(5):1006-17.


Kelz MB, Sleigh J. From the edge of oblivion: the dance between intrinsic neuronal currents and neuronal connectivity.  Anesthesiology. 2012; 116(5):977-9.


Li RQ, McKinstry AR, Moore JT, Caltagarone BM, Eckenhoff MF, Eckenhoff RG, Kelz MB.  Is hydrogen sulfide-induced suspended animation general anesthesia? J Pharmacol Exp Ther. 2012; 341(3):735-42


Pick J, Chen Y, Moore JT, Sun Y, Wyner AJ, Friedman EB, Kelz MB. Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics. Anesthesiology. 2011; 115(4):702-12.


Daley JT, Kelz MB. Time in general anesthesia: depriving the homeostat? Sleep. 2010; 33(12):1583-4.


Friedman EB, Sun Y, Moore JT, Hung HT, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB. A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. PLoS One. 2010; 5(7):e11903.


Moore JT, Kelz MB.  Opiates, sleep, and pain: the adenosinergic link.  Anesthesiology. 2009; 111(6):1175-6.


Bianchi SL, Caltagarone BM, Laferla FM, Eckenhoff RG, Kelz MB. Inhaled anesthetic potency in aged Alzheimer mice. Anesth Analg. 2010; 110(2):427-30.


Gompf H, Chen J, Sun Y, Yanagisawa M, Aston-Jones G, Kelz MB. Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents. Anesthesiology. 2009; 111(5):1001-9.


Kelz MB, Friedman E.  Anesthetic sensitivity: learning to fly. Anesthesiology. 2009; 111(1):5-7.


Scammell TE, Willie JT, Guilleminault C, Siegel JM; International Working Group on Rodent Models of Narcolepsy A consensus definition of cataplexy in mouse models of narcolepsy.  Sleep. 2009; 32(1):111-6.


Kelz MB, Eckenhoff RG. Does it add up? Anesth Analg. 2008; 107(2):365-6.


Eckenhoff R, Zheng W, Kelz M. From anesthetic mechanisms research to drug discovery.  Clin Pharmacol Ther. 2008; 84(1):144-8.


Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M. An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci U S A. 2008; 105(4):1309-14.


Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Sander T, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC. Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. Am J Hum Genet. 2007; 80(4):792-9.


Sun Y, Chen J, Pruckmayr G, Baumgardner JE, Eckmann DM, Eckenhoff RG, Kelz MB. High throughput modular chambers for rapid evaluation of anesthetic sensitivity. BMC Anesthesiol. 2006; 6:13.


Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ. An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci. 2006; 9(2):205-11.


Kelz MB, Dent GW, Therianos S, Marciano PG, McIntosh TK, Coleman PD, Eberwine JH. Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration. Sci Aging Knowledge Environ. 2002; 2002(1):re1.


Chen J, Kelz MB, Zeng G, Steffen C, Shockett PE, Terwilliger G, Schatz DG, Nestler EJ. Inducible, reversible hair loss in transgenic mice. Transgenic Res. 2002; 11(3):241-7.


Sakai N, Thome J, Newton SS, Chen J, Kelz MB, Steffen C, Nestler EJ, Duman RS. Inducible, reversible hair loss in transgenic mice. Mol Pharmacol. 2002; 61(6):1453-64.


Sims NA, Sabatakos G, Chen JS, Kelz MB, Nestler EJ, Baron R.  Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass. Bone. 2002; 30(1):32-9.


Kelz MB, Nestler EJ.  deltaFosB: a molecular switch underlying long-term neural plasticity. Curr Opin Neurol. 2000; 13(6):715-20.


Kelz MB, Kuszak JR, Yang Y, Ma W, Steffen C, Al-Ghoul K, Zhang YJ, Chen J, Nestler EJ, Spector A. DeltaFosB-induced cataract. Invest Ophthalmol Vis Sci. 2000; 41(11):3523-38.


Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med. 2000; 6(9):985-90.


Chen J, Zhang Y, Kelz MB, Steffen C, Ang ES, Zeng L, Nestler EJ. Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.  J Neurosci. 2000; 20(24):8965-71.


Kelz MB, Chen J, Carlezon WA Jr, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang YJ, Marotti L, Self DW, Tkatch T, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature. 1999; 401(6750):272-6.


Nestler EJ, Kelz MB, Chen J.  DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity. Brain Res. 1999; 835(1):10-7.


Chen J, Kelz MB, Zeng G, Sakai N, Steffen C, Shockett PE, Picciotto MR, Duman RS, Nestler EJ. Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol. 1998; 54(3):495-503.


Chen J, Kelz MB, Hope BT, Nakabeppu Y, Nestler EJ.  Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments. J Neurosci. 1997; 17(13):4933-41.


Wexler BE, Fulbright RK, Lacadie CM, Skudlarski P, Kelz MB, Constable RT, Gore JC.  An fMRI study of the human cortical motor system response to increasing functional demands. Magn Reson Imaging. 1997; 15(4):385-96.


Nye HE, Hope BT, Kelz MB, Iadarola M, Nestler EJ. Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens. J Pharmacol Exp Ther. 1995; 275(3):1671-80.


Chen J, Nye HE, Kelz MB, Hiroi N, Nakabeppu Y, Hope BT, Nestler EJ. Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments.  Mol Pharmacol. 1995; 48(5):880-9.


Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y, Duman RS, Nestler EJ. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron. 1994; 13(5):1235-44.

Hope BT, Kelz MB, Duman RS, Nestler EJ. Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics. J Neurosci. 1994; 14(7):4318-28.