Kelz Lab

Publications

View all publications from the Kelz Lab

Blain-Moraes S, Tarnal V, Vanini G, Bel-Behar T, Janke E, Picton P, Golmirzaie G, Palanca BJA, Avidan MS, Kelz MB, Mashour GA. Network Efficiency and Posterior Alpha Patterns Are Markers of Recovery from General Anesthesia: A High-Density Electroencephalography Study in Healthy Volunteers. Front Hum Neurosci. 2017 Jun 28;11:328.

Richardson AG, Liu X, Weigand PK, Hudgins ED, Stein JM, Das SR, Proekt A, Kelz MB, Zhang M, Van der Spiegel J, Lucas TH. Hippocampal gamma-slow oscillation coupling in macaques during sedation and sleep. Hippocampus. 2017 Nov;27(11):1125-1139.

Maier KL, McKinstry-Wu AR, Palanca BJA, Tarnal V, Blain-Moraes S, Basner M, Avidan MS, Mashour GA, Kelz MB. Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study. Front Hum Neurosci. 2017 Jun 7;11:284

Wasilczuk AZ, Proekt A, Kelz MB, McKinstry-Wu AR.  High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources. J Vis Exp. 2016; (117).

Erickson RL, Terzi MC, Jaber SM, Hankenson FC, McKinstry-Wu A, Kelz MB, Marx JO.  Intraperitoneal Continuous-Rate Infusion for the Maintenance of Anesthesia in Laboratory Mice (Mus musculus). J Am Assoc Lab Anim Sci. 2016; 55(5):548-57.

Gardner B, Strus E, Meng QC, Coradetti T, Naidoo NN, Kelz MB, Williams JA.  Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol? Anesthesiology. 2016; 124(2):404-16.

Drobish JK, Kelz MB, DiPuppo PM, Cook-Sather SD.  Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. A A Case Rep. 2015; 4(11):148-50.

Jaber SM, Hankenson FC, Heng K, McKinstry-Wu A, Kelz MB, Marx JO.  Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice. J Am Assoc Lab Anim Sci. 2014; 53(6):684-91.

McCarren HS, Chalifoux MR, Han B, Moore JT, Meng QC, Baron-Hionis N, Sedigh-Sarvestani M, Contreras D, Beck SG, Kelz MB.  α2-Adrenergic stimulation of the ventrolateral preoptic nucleus destabilizes the anesthetic state.  J Neurosci. 2014; 34(49):16385-96.

Han B, McCarren HS, O'Neill D, Kelz MB.  Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer. Anesthesiology. 2014; 121(5):999-1009.

McCarren HS, Moore JT, Kelz MB. Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention. J Vis Exp. 2013; (80):e51079.

Deutschman CS, Raj NR, McGuire EO, Kelz MB.  Orexinergic activity modulates altered vital signs and pituitary hormone secretion in experimental sepsis. Crit Care Med. 2013; 41(11):e368-75.

Joiner WJ, Friedman EB, Hung HT, Koh K, Sowcik M, Sehgal A, Kelz MB.  Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.  Genet. 2013; 9(9):e1003605.

Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA. Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. J Neurosci. 2013; 33(17):7264-73

Scharf MT, Kelz MB. Sleep and Anesthesia Interactions: A Pharmacological Appraisal. Curr Anesthesiol Rep. 2013; 3(1):1-9.

Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA. Incidence, predictors and outcomes of postoperative coma: an observational study of 858,606 patients. Eur J Anaesthesiol. 2013; 30(8):476-82.

Weiser BP, Kelz MB, Eckenhoff RG. In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets. J Biol Chem. 2013; 288(2):1279-85.

Moore JT, Chen J, Han B, Meng QC, Veasey SC, Beck SG, Kelz MB. Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis. Curr Biol. 2012; 22(21):2008-16.

Hu FY, Hanna GM, Han W, Mardini F, Thomas SA, Wyner AJ, Kelz MB. Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice.  Anesthesiology. 2012; 117(5):1006-17.

Kelz MB, Sleigh J. From the edge of oblivion: the dance between intrinsic neuronal currents and neuronal connectivity.  Anesthesiology. 2012; 116(5):977-9.

Li RQ, McKinstry AR, Moore JT, Caltagarone BM, Eckenhoff MF, Eckenhoff RG, Kelz MB.  Is hydrogen sulfide-induced suspended animation general anesthesia? J Pharmacol Exp Ther. 2012; 341(3):735-42

Pick J, Chen Y, Moore JT, Sun Y, Wyner AJ, Friedman EB, Kelz MB. Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics. Anesthesiology. 2011; 115(4):702-12.

Daley JT, Kelz MB. Time in general anesthesia: depriving the homeostat? Sleep. 2010; 33(12):1583-4.

Friedman EB, Sun Y, Moore JT, Hung HT, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB. A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. PLoS One. 2010; 5(7):e11903.

Moore JT, Kelz MB.  Opiates, sleep, and pain: the adenosinergic link.  Anesthesiology. 2009; 111(6):1175-6.

Bianchi SL, Caltagarone BM, Laferla FM, Eckenhoff RG, Kelz MB. Inhaled anesthetic potency in aged Alzheimer mice. Anesth Analg. 2010; 110(2):427-30.

Gompf H, Chen J, Sun Y, Yanagisawa M, Aston-Jones G, Kelz MB. Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents. Anesthesiology. 2009; 111(5):1001-9.

Kelz MB, Friedman E.  Anesthetic sensitivity: learning to fly. Anesthesiology. 2009; 111(1):5-7.

Scammell TE, Willie JT, Guilleminault C, Siegel JM; International Working Group on Rodent Models of Narcolepsy A consensus definition of cataplexy in mouse models of narcolepsy.  Sleep. 2009; 32(1):111-6.

Kelz MB, Eckenhoff RG. Does it add up? Anesth Analg. 2008; 107(2):365-6.

Eckenhoff R, Zheng W, Kelz M. From anesthetic mechanisms research to drug discovery.  Clin Pharmacol Ther. 2008; 84(1):144-8.

Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M. An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci U S A. 2008; 105(4):1309-14.

Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Sander T, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC. Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. Am J Hum Genet. 2007; 80(4):792-9.

Sun Y, Chen J, Pruckmayr G, Baumgardner JE, Eckmann DM, Eckenhoff RG, Kelz MB. High throughput modular chambers for rapid evaluation of anesthetic sensitivity. BMC Anesthesiol. 2006; 6:13.

Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ. An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci. 2006; 9(2):205-11.

Kelz MB, Dent GW, Therianos S, Marciano PG, McIntosh TK, Coleman PD, Eberwine JH. Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration. Sci Aging Knowledge Environ. 2002; 2002(1):re1.

Chen J, Kelz MB, Zeng G, Steffen C, Shockett PE, Terwilliger G, Schatz DG, Nestler EJ. Inducible, reversible hair loss in transgenic mice. Transgenic Res. 2002; 11(3):241-7.

Sakai N, Thome J, Newton SS, Chen J, Kelz MB, Steffen C, Nestler EJ, Duman RS. Inducible, reversible hair loss in transgenic mice. Mol Pharmacol. 2002; 61(6):1453-64.

Sims NA, Sabatakos G, Chen JS, Kelz MB, Nestler EJ, Baron R.  Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass. Bone. 2002; 30(1):32-9.

Kelz MB, Nestler EJ.  deltaFosB: a molecular switch underlying long-term neural plasticity. Curr Opin Neurol. 2000; 13(6):715-20.

Kelz MB, Kuszak JR, Yang Y, Ma W, Steffen C, Al-Ghoul K, Zhang YJ, Chen J, Nestler EJ, Spector A. DeltaFosB-induced cataract. Invest Ophthalmol Vis Sci. 2000; 41(11):3523-38.

Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med. 2000; 6(9):985-90.

Chen J, Zhang Y, Kelz MB, Steffen C, Ang ES, Zeng L, Nestler EJ. Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.  J Neurosci. 2000; 20(24):8965-71.

Kelz MB, Chen J, Carlezon WA Jr, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang YJ, Marotti L, Self DW, Tkatch T, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature. 1999; 401(6750):272-6.

Nestler EJ, Kelz MB, Chen J.  DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity. Brain Res. 1999; 835(1):10-7.

Chen J, Kelz MB, Zeng G, Sakai N, Steffen C, Shockett PE, Picciotto MR, Duman RS, Nestler EJ. Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol. 1998; 54(3):495-503.

Chen J, Kelz MB, Hope BT, Nakabeppu Y, Nestler EJ.  Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments. J Neurosci. 1997; 17(13):4933-41.

Wexler BE, Fulbright RK, Lacadie CM, Skudlarski P, Kelz MB, Constable RT, Gore JC.  An fMRI study of the human cortical motor system response to increasing functional demands. Magn Reson Imaging. 1997; 15(4):385-96.

Nye HE, Hope BT, Kelz MB, Iadarola M, Nestler EJ. Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens. J Pharmacol Exp Ther. 1995; 275(3):1671-80.

Chen J, Nye HE, Kelz MB, Hiroi N, Nakabeppu Y, Hope BT, Nestler EJ. Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments.  Mol Pharmacol. 1995; 48(5):880-9.

Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y, Duman RS, Nestler EJ. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron. 1994; 13(5):1235-44.

Hope BT, Kelz MB, Duman RS, Nestler EJ. Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics. J Neurosci. 1994; 14(7):4318-28.


© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.