Kelz Lab Publications

A Novel Conditional Adra2a-Knockout Mouse Line Reveals Cell-specific Contributions to Specific Dimensions of Sedation.

bioRxiv : the preprint server for biology. 2026 Apr 17 ; Authors: Fryou NL, Jiang T, Frick N, Kwasniewska P, Lipin MY, Kelz MB, Thomas SA, McKinstry-Wu A

Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons.

Research square. 2025 Nov 19 ; Authors: Wasilczuk AZ, Takekawa D, Cichon J, Zhang X, Blackwood EB, Parra-Munevar J, Kim MH, Spain W, Krom AJ, Kelz MB, Dembrow N, Proekt A

Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons.

bioRxiv : the preprint server for biology. 2025 Oct 17 ; Authors: Wasilczuk AZ, Takekawa D, Cichon J, Zhang X, Blackwood E, Parra-Munevar J, Kim MH, Spain W, Krom A, Kelz MB, Dembrow N, Proekt A

Current and Developing Approaches for Facilitating Emergence from General Anesthesia.

Anesthesiology. 2025 Oct 1;143(4):1049-1089 Epub 2025 Sep 9 ; Authors: Vincent KF, Pal D, Xie Z, Fox AP, White ER, Kelz MB, García PS, Calderon DP, Plourde G, Vlisides PE, Solt K

Reanimation of rodents: an animal model for cognitive recovery from anaesthesia.

British journal of anaesthesia. 2025 Oct;135(4):847-850 Epub 2025 Aug 29 ; Authors: McKinstry-Wu AR, Kelz MB

Effects of the Quinone Analog Ubiquinone-5 on Murine Mitochondria and Hypnosis.

Anesthesiology. 2025 Sep 1;143(3):641-660 Epub 2025 May 2 ; Authors: Somnay YR, Wang A, Lim H, Griffiths KK, Zandkarimi F, Chen K, Yang G, Wasilczuk AZ, Kelz MB, Larr D, Yang M, Gil-Iturbe E, Moon A, Quick M, Levy RJ

Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.

Communications biology. 2025 Aug 20;8(1):1254 ; Authors: Fotiadis P, McKinstry-Wu AR, Weinstein SM, Cook PA, Elliott M, Cieslak M, Duda JT, Satterthwaite TD, Shinohara RT, Proekt A, Kelz MB, Detre JA, Bassett DS

A probabilistic model of behavioural emergence from general anaesthesia in mice.

British journal of anaesthesia. 2025 Jul;135(1):121-133 Epub 2025 Apr 25 ; Authors: Stone ME, Kelz MB, Proekt A, Wasilczuk AZ

Parafacial GABAergic neurone ablation induces behavioural resistance to volatile anaesthetic-induced hypnosis without reducing sleep.

British journal of anaesthesia. 2025 Jun;134(6):1696-1708 Epub 2025 Apr 15 ; Authors: Imamura T, Wasilczuk AZ, Reitz SL, Lian J, Imamura M, Keenan BT, Shimizu N, Pack AI, Kelz MB

The Administration of Ketamine Is Associated with Dose-Dependent Stabilization of Cortical Dynamics in Humans.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025 May 14;45(20) ; Authors: Dávila DG, McKinstry-Wu A, Kelz MB, Proekt A

Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect.

Nature communications. 2025 Apr 3;16(1):2999 ; Authors: Cichon J, Joseph TT, Lu X, Wasilczuk AZ, Kelz MB, Mennerick SJ, Zorumski CF, Nagele P

Alluring Potential to Accelerate Emergence and Ameliorate Opioid-induced Respiratory Depression without Antagonizing Analgesia: Danavorexton Enters the Anesthetic Landscape.

Anesthesiology. 2025 Apr 1;142(4):589-592 Epub 2025 Mar 11 ; Authors: Imamura T, Kelz MB

Nitrous Oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect.

Research square. 2024 Nov 15 ; Authors: Cichon J, Joseph TT, Lu X, Wasilczuk AZ, Kelz MB, Mennerick SJ, Zorumski CF, Nagele P

Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.

bioRxiv : the preprint server for biology. 2024 Nov 12 ; Authors: Fotiadis P, McKinstry-Wu AR, Weinstein SM, Cook PA, Elliott M, Cieslak M, Duda JT, Satterthwaite TD, Shinohara RT, Proekt A, Kelz MB, Detre JA, Bassett DS

Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states.

Cell reports. 2024 Apr 23;43(4):114017 Epub 2024 Apr 4 ; Authors: Aggarwal A, Luo J, Chung H, Contreras D, Kelz MB, Proekt A

One node among many: sevoflurane-induced hypnosis and the challenge of an integrative network-level view of anaesthetic action.

British journal of anaesthesia. 2024 Feb;132(2):220-223 Epub 2023 Nov 23 ; Authors: McKinstry-Wu AR, Kelz MB

Hormonal basis of sex differences in anesthetic sensitivity.

Proceedings of the National Academy of Sciences of the United States of America. 2024 Jan 16;121(3):e2312913120 Epub 2024 Jan 8 ; Authors: Wasilczuk AZ, Rinehart C, Aggarwal A, Stone ME, Mashour GA, Avidan MS, Kelz MB, Proekt A, ReCCognition Study Group

Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states.

bioRxiv : the preprint server for biology. 2023 May 23 ; Authors: Aggarwal A, Luo J, Chung H, Contreras D, Kelz MB, Proekt A

In Vivo Photoadduction of Anesthetic Ligands in Mouse Brain Markedly Extends Sedation and Hypnosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023 Mar 29;43(13):2338-2348 Epub 2023 Feb 27 ; Authors: McKinstry-Wu AR, Wasilczuk AZ, Dailey WP, Eckenhoff RG, Kelz MB

The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia.

British journal of anaesthesia. 2023 Feb;130(2):e233-e242 Epub 2022 Feb 17 ; Authors: Labonte AK, Kafashan M, Huels ER, Blain-Moraes S, Basner M, Kelz MB, Mashour GA, Avidan MS, Palanca BJA, ReCCognition Study Group

Ketamine triggers a switch in excitatory neuronal activity across neocortex.

Nature neuroscience. 2023 Jan;26(1):39-52 Epub 2022 Nov 24 ; Authors: Cichon J, Wasilczuk AZ, Looger LL, Contreras D, Kelz MB, Proekt A

Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2022 Oct;142:125-132 Epub 2022 Jul 30 ; Authors: Kafashan M, Brian Hickman L, Labonte AK, Huels ER, Maybrier H, Guay CS, Subramanian S, Farber NB, Ching S, Hogan RE, Kelz MB, Avidan MS, Mashour GA, Palanca BJA

Visual evoked feedforward-feedback traveling waves organize neural activity across the cortical hierarchy in mice.

Nature communications. 2022 Aug 13;13(1):4754 ; Authors: Aggarwal A, Brennan C, Luo J, Chung H, Contreras D, Kelz MB, Proekt A

Anesthesia: Synaptic power failure.

Current biology : CB. 2022 Jul 25;32(14):R781-R783 ; Authors: van Swinderen B, Kelz MB

Consciousness Rebound: The Second-Century Challenge for Anesthesiology and Neuroscience.

Anesthesia and analgesia. 2022 Jun 1;134(6):1114-1117 Epub 2022 May 10 ; Authors: Kelz MB

Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness.

Frontiers in human neuroscience. 2021;15:706693 Epub 2021 Sep 14 ; Authors: Rokos A, Mišić B, Berkun K, Duclos C, Tarnal V, Janke E, Picton P, Golmirzaie G, Basner M, Avidan MS, Kelz MB, Mashour GA, Blain-Moraes S

Differential classification of states of consciousness using envelope- and phase-based functional connectivity.

NeuroImage. 2021 Aug 15;237:118171 Epub 2021 May 15 ; Authors: Duclos C, Maschke C, Mahdid Y, Berkun K, Castanheira JDS, Tarnal V, Picton P, Vanini G, Golmirzaie G, Janke E, Avidan MS, Kelz MB, Liuzzi L, Brookes MJ, Mashour GA, Blain-Moraes S

QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data.

Nature methods. 2021 Jul;18(7):775-778 Epub 2021 Jun 21 ; Authors: Cieslak M, Cook PA, He X, Yeh FC, Dhollander T, Adebimpe A, Aguirre GK, Bassett DS, Betzel RF, Bourque J, Cabral LM, Davatzikos C, Detre JA, Earl E, Elliott MA, Fadnavis S, Fair DA, Foran W, Fotiadis P, Garyfallidis E, Giesbrecht B, Gur RC, Gur RE, Kelz MB, Keshavan A, Larsen BS, Luna B, Mackey AP, Milham MP, Oathes DJ, Perrone A, Pines AR, Roalf DR, Richie-Halford A, Rokem A, Sydnor VJ, Tapera TM, Tooley UA, Vettel JM, Yeatman JD, Grafton ST, Satterthwaite TD

Recovery of consciousness and cognition after general anesthesia in humans.

eLife. 2021 May 10;10 ; Authors: Mashour GA, Palanca BJ, Basner M, Li D, Wang W, Blain-Moraes S, Lin N, Maier K, Muench M, Tarnal V, Vanini G, Ochroch EA, Hogg R, Schwartz M, Maybrier H, Hardie R, Janke E, Golmirzaie G, Picton P, McKinstry-Wu AR, Avidan MS, Kelz MB

Brain network motifs are markers of loss and recovery of consciousness.

Scientific reports. 2021 Feb 16;11(1):3892 ; Authors: Duclos C, Nadin D, Mahdid Y, Tarnal V, Picton P, Vanini G, Golmirzaie G, Janke E, Avidan MS, Kelz MB, Mashour GA, Blain-Moraes S

Preoptic Area Modulation of Arousal in Natural and Drug Induced Unconscious States.

Frontiers in neuroscience. 2021;15:644330 Epub 2021 Feb 12 ; Authors: Reitz SL, Kelz MB

Theta Synchrony Is Increased near Neural Populations That Are Active When Initiating Instructed Movement.

eNeuro. 2021 Jan-Feb;8(1) Epub 2021 Feb 8 ; Authors: Ramayya AG, Yang AI, Buch VP, Burke JF, Richardson AG, Brandon C, Stein JM, Davis KA, Chen HI, Proekt A, Kelz MB, Litt B, Gold JI, Lucas TH

Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia.

Scientific reports. 2021 Feb 4;11(1):3148 ; Authors: Venincasa MJ, Randlett O, Sumathipala SH, Bindernagel R, Stark MJ, Yan Q, Sloan SA, Buglo E, Meng QC, Engert F, Züchner S, Kelz MB, Syed S, Dallman JE

Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness.

Current biology : CB. 2021 Jan 25;31(2):394-405.e4 Epub 2020 Nov 13 ; Authors: Reitz SL, Wasilczuk AZ, Beh GH, Proekt A, Kelz MB

Explaining anaesthetic hysteresis with effect-site equilibration.

British journal of anaesthesia. 2021 Jan;126(1):265-278 Epub 2020 Oct 17 ; Authors: Proekt A, Kelz MB

Creation of the Anesthesia Research Council.

Anesthesia and analgesia. 2020 Oct;131(4):1300-1303 ; Authors: Culley DJ, Kelz MB, Koch CG, Eisenach JC, Neuman MD, Whitlock EL, Robertson RM, Cooper T, Pomerantz P

Resistance to state transitions in responsiveness is differentially modulated by different volatile anaesthetics in male mice.

British journal of anaesthesia. 2020 Sep;125(3):308-320 Epub 2020 Jul 11 ; Authors: Wasilczuk AZ, Harrison BA, Kwasniewska P, Ku B, Kelz MB, McKinstry-Wu AR, Proekt A

Neural Inertia: A Sticky Situation for Anesthesia.

Journal of neurosurgical anesthesiology. 2020 Jul;32(3):190-192 ; Authors: McKinstry-Wu AR, Proekt A, Kelz MB

Patterns of Hysteresis Between Induction and Emergence of Neuroanesthesia Are Present in Spinal and Intracranial Surgeries.

Journal of neurosurgical anesthesiology. 2020 Jan;32(1):82-89 ; Authors: Ferreira AL, Correia R, Vide S, Ferreira AD, Kelz MB, Mendes JG, Nunes CS, Amorim P

Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia.

eLife. 2019 Dec 3;8 ; Authors: McKinstry-Wu AR, Wasilczuk AZ, Harrison BA, Bedell VM, Sridharan MJ, Breig JJ, Pack M, Kelz MB, Proekt A

The Biology of General Anesthesia from Paramecium to Primate.

Current biology : CB. 2019 Nov 18;29(22):R1199-R1210 ; Authors: Kelz MB, Mashour GA

Be Wary of Genes Governing Awareness.

Anesthesiology. 2019 Nov;131(5):955-956 ; Authors: Morgan PG, Kelz MB

Duration of EEG suppression does not predict recovery time or degree of cognitive impairment after general anaesthesia in human volunteers.

British journal of anaesthesia. 2019 Aug;123(2):206-218 Epub 2019 Jun 13 ; Authors: Shortal BP, Hickman LB, Mak-McCully RA, Wang W, Brennan C, Ung H, Litt B, Tarnal V, Janke E, Picton P, Blain-Moraes S, Maybrier HR, Muench MR, Lin N, Avidan MS, Mashour GA, McKinstry-Wu AR, Kelz MB, Palanca BJ, Proekt A, ReCCognition Study Group

Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.

Trends in pharmacological sciences. 2019 Jul;40(7):464-481 Epub 2019 May 27 ; Authors: Hemmings HC Jr, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA

Dynamic Cortical Connectivity during General Anesthesia in Healthy Volunteers.

Anesthesiology. 2019 Jun;130(6):870-884 ; Authors: Li D, Vlisides PE, Kelz MB, Avidan MS, Mashour GA, ReCCognition Study Group

Coherence of Visual-Evoked Gamma Oscillations Is Disrupted by Propofol but Preserved Under Equipotent Doses of Isoflurane.

Frontiers in systems neuroscience. 2019;13:19 Epub 2019 May 8 ; Authors: Aggarwal A, Brennan C, Shortal B, Contreras D, Kelz MB, Proekt A

Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia.

Anesthesia and analgesia. 2019 Apr;128(4):726-736 ; Authors: Kelz MB, García PS, Mashour GA, Solt K

Cognitive and Neurophysiological Recovery Following Electroconvulsive Therapy: A Study Protocol.

Frontiers in psychiatry. 2018;9:171 Epub 2018 May 14 ; Authors: Palanca BJA, Maybrier HR, Mickle AM, Farber NB, Hogan RE, Trammel ER, Spencer JW, Bohnenkamp DD, Wildes TS, Ching S, Lenze E, Basner M, Kelz MB, Avidan MS

Development and validation of brain target controlled infusion of propofol in mice.

PloS one. 2018;13(4):e0194949 Epub 2018 Apr 23 ; Authors: Shortal BP, Reitz SL, Aggarwal A, Meng QC, McKinstry-Wu AR, Kelz MB, Proekt A

Systems Neuroscience: The Exciting Journey to Oblivion.

Current biology : CB. 2018 Mar 5;28(5):R223-R224 ; Authors: Mashour GA, Kelz MB

Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration.

Methods in enzymology. 2018;602:289-298 Epub 2018 Mar 3 ; Authors: McKinstry-Wu A, Carspecken CW, Proekt A, Kelz MB

Optoanesthesia: Use of Anesthetic Photolabels In Vivo.

Methods in enzymology. 2018;603:171-180 Epub 2018 Mar 24 ; Authors: McKinstry-Wu AR, Kelz MB

The Mouse as a Model Organism for Assessing Anesthetic Sensitivity.

Methods in enzymology. 2018;602:211-228 Epub 2018 Mar 6 ; Authors: Wasilczuk AZ, Maier KL, Kelz MB

Hippocampal gamma-slow oscillation coupling in macaques during sedation and sleep.

Hippocampus. 2017 Nov;27(11):1125-1139 Epub 2017 Jul 12 ; Authors: Richardson AG, Liu X, Weigand PK, Hudgins ED, Stein JM, Das SR, Proekt A, Kelz MB, Zhang M, Van der Spiegel J, Lucas TH

Network Efficiency and Posterior Alpha Patterns Are Markers of Recovery from General Anesthesia: A High-Density Electroencephalography Study in Healthy Volunteers.

Frontiers in human neuroscience. 2017;11:328 Epub 2017 Jun 28 ; Authors: Blain-Moraes S, Tarnal V, Vanini G, Bel-Behar T, Janke E, Picton P, Golmirzaie G, Palanca BJA, Avidan MS, Kelz MB, Mashour GA

Protocol for the Reconstructing Consciousness and Cognition (ReCCognition) Study.

Frontiers in human neuroscience. 2017;11:284 Epub 2017 Jun 7 ; Authors: Maier KL, McKinstry-Wu AR, Palanca BJA, Tarnal V, Blain-Moraes S, Basner M, Avidan MS, Mashour GA, Kelz MB

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources.

Journal of visualized experiments : JoVE. 2016 Nov 26;(117) ; Authors: Wasilczuk AZ, Proekt A, Kelz MB, McKinstry-Wu AR

Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol?

Anesthesiology. 2016 Feb;124(2):404-16 ; Authors: Gardner B, Strus E, Meng QC, Coradetti T, Naidoo NN, Kelz MB, Williams JA

Intraperitoneal Continuous-Rate Infusion for the Maintenance of Anesthesia in Laboratory Mice (Mus musculus).

Journal of the American Association for Laboratory Animal Science : JAALAS. 2016;55(5):548-57 ; Authors: Erickson RL, Terzi MC, Jaber SM, Hankenson FC, McKinstry-Wu A, Kelz MB, Marx JO

Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient.

A & A case reports. 2015 Jun 1;4(11):148-50 ; Authors: Drobish JK, Kelz MB, DiPuppo PM, Cook-Sather SD

α2-Adrenergic stimulation of the ventrolateral preoptic nucleus destabilizes the anesthetic state.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Dec 3;34(49):16385-96 ; Authors: McCarren HS, Chalifoux MR, Han B, Moore JT, Meng QC, Baron-Hionis N, Sedigh-Sarvestani M, Contreras D, Beck SG, Kelz MB

Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer.

Anesthesiology. 2014 Nov;121(5):999-1009 ; Authors: Han B, McCarren HS, O'Neill D, Kelz MB

Dose regimens, variability, and complications associated with using repeat-bolus dosing to extend a surgical plane of anesthesia in laboratory mice.

Journal of the American Association for Laboratory Animal Science : JAALAS. 2014 Nov;53(6):684-91 ; Authors: Jaber SM, Hankenson FC, Heng K, McKinstry-Wu A, Kelz MB, Marx JO

Orexinergic activity modulates altered vital signs and pituitary hormone secretion in experimental sepsis.

Critical care medicine. 2013 Nov;41(11):e368-75 ; Authors: Deutschman CS, Raj NR, McGuire EO, Kelz MB

Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention.

Journal of visualized experiments : JoVE. 2013 Oct 16;(80):e51079 ; Authors: McCarren HS, Moore JT, Kelz MB

Incidence, predictors and outcomes of postoperative coma: an observational study of 858,606 patients.

European journal of anaesthesiology. 2013 Aug;30(8):476-82 ; Authors: Newman J, Blake K, Fennema J, Harris D, Shanks A, Avidan MS, Kelz MB, Mashour GA

Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Apr 24;33(17):7264-73 ; Authors: Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA

Sleep and Anesthesia Interactions: A Pharmacological Appraisal.

Current anesthesiology reports. 2013 Mar 1;3(1):1-9 ; Authors: Scharf MT, Kelz MB

In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets.

The Journal of biological chemistry. 2013 Jan 11;288(2):1279-85 Epub 2012 Nov 26 ; Authors: Weiser BP, Kelz MB, Eckenhoff RG

Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.

PLoS genetics. 2013;9(9):e1003605 Epub 2013 Sep 5 ; Authors: Joiner WJ, Friedman EB, Hung HT, Koh K, Sowcik M, Sehgal A, Kelz MB

Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis.

Current biology : CB. 2012 Nov 6;22(21):2008-16 Epub 2012 Oct 25 ; Authors: Moore JT, Chen J, Han B, Meng QC, Veasey SC, Beck SG, Kelz MB

Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice.

Anesthesiology. 2012 Nov;117(5):1006-17 ; Authors: Hu FY, Hanna GM, Han W, Mardini F, Thomas SA, Wyner AJ, Kelz MB

Is hydrogen sulfide-induced suspended animation general anesthesia?

The Journal of pharmacology and experimental therapeutics. 2012 Jun;341(3):735-42 Epub 2012 Mar 13 ; Authors: Li RQ, McKinstry AR, Moore JT, Caltagarone BM, Eckenhoff MF, Eckenhoff RG, Kelz MB

From the edge of oblivion: the dance between intrinsic neuronal currents and neuronal connectivity.

Anesthesiology. 2012 May;116(5):977-9 ; Authors: Kelz MB, Sleigh J

Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics.

Anesthesiology. 2011 Oct;115(4):702-12 ; Authors: Pick J, Chen Y, Moore JT, Sun Y, Wyner AJ, Friedman EB, Kelz MB

Time in general anesthesia: depriving the homeostat?

Sleep. 2010 Dec;33(12):1583-4 ; Authors: Daley JT, Kelz MB

A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia.

PloS one. 2010 Jul 30;5(7):e11903 ; Authors: Friedman EB, Sun Y, Moore JT, Hung HT, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB

Inhaled anesthetic potency in aged Alzheimer mice.

Anesthesia and analgesia. 2010 Feb 1;110(2):427-30 Epub 2009 Oct 9 ; Authors: Bianchi SL, Caltagarone BM, Laferla FM, Eckenhoff RG, Kelz MB

Opiates, sleep, and pain: the adenosinergic link.

Anesthesiology. 2009 Dec;111(6):1175-6 ; Authors: Moore JT, Kelz MB

Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents.

Anesthesiology. 2009 Nov;111(5):1001-9 ; Authors: Gompf H, Chen J, Sun Y, Yanagisawa M, Aston-Jones G, Kelz MB

Anesthetic sensitivity: learning to fly.

Anesthesiology. 2009 Jul;111(1):5-7 ; Authors: Kelz MB, Friedman E

Does it add up?

Anesthesia and analgesia. 2008 Aug;107(2):365-6 ; Authors: Kelz MB, Eckenhoff RG

From anesthetic mechanisms research to drug discovery.

Clinical pharmacology and therapeutics. 2008 Jul;84(1):144-8 Epub 2008 Apr 30 ; Authors: Eckenhoff R, Zheng W, Kelz M

An essential role for orexins in emergence from general anesthesia.

Proceedings of the National Academy of Sciences of the United States of America. 2008 Jan 29;105(4):1309-14 Epub 2008 Jan 14 ; Authors: Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M

Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.

American journal of human genetics. 2007 Apr;80(4):792-9 Epub 2007 Feb 12 ; Authors: Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Sander T, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC

High throughput modular chambers for rapid evaluation of anesthetic sensitivity.

BMC anesthesiology. 2006 Nov 10;6:13 ; Authors: Sun Y, Chen J, Pruckmayr G, Baumgardner JE, Eckmann DM, Eckenhoff RG, Kelz MB

An essential role for DeltaFosB in the nucleus accumbens in morphine action.

Nature neuroscience. 2006 Feb;9(2):205-11 Epub 2006 Jan 15 ; Authors: Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ

Inducible and brain region-specific CREB transgenic mice.

Molecular pharmacology. 2002 Jun;61(6):1453-64 ; Authors: Sakai N, Thome J, Newton SS, Chen J, Kelz MB, Steffen C, Nestler EJ, Duman RS

Inducible, reversible hair loss in transgenic mice.

Transgenic research. 2002 Jun;11(3):241-7 ; Authors: Chen J, Kelz MB, Zeng G, Steffen C, Shockett PE, Terwilliger G, Schatz DG, Nestler EJ

Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration.

Science of aging knowledge environment : SAGE KE. 2002 Jan 9;2002(1):re1 ; Authors: Kelz MB, Dent GW, Therianos S, Marciano PG, McIntosh TK, Coleman PD, Eberwine JH

Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass.

Bone. 2002 Jan;30(1):32-9 ; Authors: Sims NA, Sabatakos G, Chen JS, Kelz MB, Nestler EJ, Baron R

Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Dec 15;20(24):8965-71 ; Authors: Chen J, Zhang Y, Kelz MB, Steffen C, Ang ES, Zeng L, Nestler EJ

deltaFosB: a molecular switch underlying long-term neural plasticity.

Current opinion in neurology. 2000 Dec;13(6):715-20 ; Authors: Kelz MB, Nestler EJ

DeltaFosB-induced cataract.

Investigative ophthalmology & visual science. 2000 Oct;41(11):3523-38 ; Authors: Kelz MB, Kuszak JR, Yang Y, Ma W, Steffen C, Al-Ghoul K, Zhang YJ, Chen J, Nestler EJ, Spector A

Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis.

Nature medicine. 2000 Sep;6(9):985-90 ; Authors: Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R

Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine.

Nature. 1999 Sep 16;401(6750):272-6 ; Authors: Kelz MB, Chen J, Carlezon WA Jr, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang YJ, Marotti L, Self DW, Tkatch T, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ

DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity.

Brain research. 1999 Jul 17;835(1):10-7 ; Authors: Nestler EJ, Kelz MB, Chen J

Transgenic animals with inducible, targeted gene expression in brain.

Molecular pharmacology. 1998 Sep;54(3):495-503 ; Authors: Chen J, Kelz MB, Zeng G, Sakai N, Steffen C, Shockett PE, Picciotto MR, Duman RS, Nestler EJ

Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 1997 Jul 1;17(13):4933-41 ; Authors: Chen J, Kelz MB, Hope BT, Nakabeppu Y, Nestler EJ

An fMRI study of the human cortical motor system response to increasing functional demands.

Magnetic resonance imaging. 1997;15(4):385-96 ; Authors: Wexler BE, Fulbright RK, Lacadie CM, Skudlarski P, Kelz MB, Constable RT, Gore JC

Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens.

The Journal of pharmacology and experimental therapeutics. 1995 Dec;275(3):1671-80 ; Authors: Nye HE, Hope BT, Kelz MB, Iadarola M, Nestler EJ

Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments.

Molecular pharmacology. 1995 Nov;48(5):880-9 ; Authors: Chen J, Nye HE, Kelz MB, Hiroi N, Nakabeppu Y, Hope BT, Nestler EJ

Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.

Neuron. 1994 Nov;13(5):1235-44 ; Authors: Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y, Duman RS, Nestler EJ

Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 1994 Jul;14(7):4318-28 ; Authors: Hope BT, Kelz MB, Duman RS, Nestler EJ