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Hee Kwon Song, Ph.D.

Associate Professor of Radiology
Deputy Director, Laboratory for Structural NMR Imaging

Area: Novel DCE-MRI methodologies based on radial data acquisition; novel motion compensation strategies; in vivo iron quantification techniques.

Department of Radiology
University of Pennsylvania Health System
1 Founders Building
3400 Spruce Street
Philadelphia, PA 19104
P : (215) 662-6265
F : (215) 662-7263

Dr. Song develops novel dynamic contrast-enhanced MRI strategies for assessing tumor perfusion and its response to therapies.

DCE-MRI Strategies for Tumor Assessment:

Dr. Song’s research focuses on the development of dynamic contrast-enhanced (DCE-) MRI strategies based on radial data acquisition and reconstruction that allow ultra-rapid dynamic imaging at both high spatial and high temporal resolutions. Utilizing the golden angle radial acquisition strategy, Dr. Song also developed and implemented highly effective strategies for motion compensation, which work in conjunction with the radial acquisition strategy to account for physiologic motion. The technique also permits the reconstruction of the dynamic series to be highly flexible, allowing many of the decisions regarding spatial/temporal resolution to be made retrospectively and optimally. These strategies are currently being utilized for the assessment of treatment effects in various tumors, including lung, liver, breast, kidney and ovarian/fallopian tube.



a) Standard Cartesian DCE-MRI time series. Notice the changes in shape and position of the lung lesion with respiration.
b) Golden angle radial acquisition with retrospective gating. The lesion now appears stationary with retrospective gating, making accurate tumor perfusion analysis possible.