Agenda

10:00am – 10:05am

Welcome and Opening Remarks 

Executive Vice Dean and Chief Scientific Office Jonathan Epstein, MD

10:05am – 10:15am 

Overview of Penn’s Lynch syndrome program

Bryson Katona, MD, PhD

10:15am – 10:35am 

"Lynch syndrome genetics and cancer risks"

Katherine Nathanson, MD

10:35am – 10:55am 

"Colorectal cancer prevention in Lynch syndrome" 

Kirk Wangensteen, MD, PhD

11:15am – 11:35am 

"Cancer screening and prevention in Lynch syndrome outside of the colon"

Jessica Long, MS, CGC

11:35am-12:15pm

Multidisciplinary Panel Q&A 

Moderator: Bryson Katona, MD, PhD

•Gastroenterology: Greg Ginsberg, MD &, Kirk Wangensteen, MD, PhD

•Gynecology: Elizabeth Clement, MD &  Ashley Haggerty, MD, MSCE

•Dermatology: Emily Chu MD, PhD

•Genetics: Jessica Long, MS, CGC

•Urology: Bruce Malkowicz, MD

•Colorectal surgery: Cary Aarons, MD, MSEd 

•Oncology: Kim Reiss-Binder, MD, Susan Domchek, MD 

12:15pm-1:15pm

Lunch/Small group lunch sessions (in-person attendees only)

•Gynecologic cancer screening and risk management – Elizabeth Clement, MD & Ashley Haggerty, MD, MSCE 

•Chemoprevention of colorectal cancer in Lynch syndrome – Kirk Wangensteen, MD, PhD

•Dermatologic cancer screening – Todd Ridky, MD, PhD

•Communicating results and risks to family members – Jessica Long, MS, CGC

•Prostate cancer screening and risk management – Kara Maxwell, MD, PhD

•Colorectal surgical decision-making – Erica Pettke, MD, MPH

•Breast cancer screening in Lynch syndrome – Susan Domchek, MD 

•Lynch syndrome research opportunities – Gillain Constantino

1:15pm- 1:35pm 

"Use of patient derived samples to drive translational research" 

Allison Greenplate, PhD

1:35pm- 1:55pm 

"Dendritic cell vaccination for hypermutant colorectal cancer" 

Kim Reiss-Binder , MD

1:55pm-2:40pm 

Borrelli Family Keynote Speaker – "Immunotherapy in Lynch syndrome"

Luis Alberto Diaz  Jr., MD

Memorial Sloan Kettering Cancer Center

2:40pm-3:00pm 

Break

3:00pm-3:10pm 

Overview of Penn’s Lynch syndrome program resources and opportunities for collaboration

Bryson Katona, MD, PhD & John Wherry, PhD

3:10pm-3:22pm

“Diet and metabolite-based interventions for Lynch syndrome”

Maayan Levy, PhD

3:22pm-3:34pm

“Organoid models of carcinoma-tumor microenvironment interactions in colon cancer”

Christopher Lengner, PhD 

3:34pm-3:46pm

"Familial Communication: ECHOes through the Family Tree"

Jacquelyn Powers, MS, CGC

3:46pm-3:58pm

“Upper gastrointestinal cancer surveillance outcomes in Lynch Syndrome”

Bryson Katona, MD, PhD

3:58pm-4:10pm

“Leveraging the Electronic Health Record to Promote Guideline-Recommended Cancer Risk Management in Patients with Lynch Syndrome”

Kelsey Lau-Min, MD

4:10pm-4:22pm

“Role of DNA damage and repair in the immune system in patients with Lynch Syndrome”

John Wherry, PhD

4:22pm-4:34pm

“Factors associated with completion of gastrointestinal cancer genetic evaluation”

Jessica Ebrahimzadeh, MS, CGC

4:34pm-4:46pm

“A Dendritic Cell vaccine for Colorectal Cancer”

Beatriz Carreno, PhD 

5:00pm-6:00pm

Happy Hour (in-person attendees only)