Marylyn D. Ritchie, PhD

microscope Marylyn D. Ritchie, PhD

Director, Center for Translational Bioinformatics

Associate Director, Penn Center for Precision Medicine

Complex analysis of big data in genetics, genomics, and clinical databases, pharmacogenomics

Marylyn D. Ritchie, PhD, is a Professor of Genetics, Director of the Center for Translational Bioinformatics, Associate Director for Bioinformatics in the Institute for Biomedical Informatics, and Associate director of the Center for Precision Medicine at the University of Pennsylvania School of Medicine. Dr. Ritchie is a statistical and computational geneticist with a focus on understanding genetic architecture of complex human disease. She has expertise in developing novel bioinformatics tools for complex analysis of big data in genetics, genomics, and clinical databases, in particular in the area of Pharmacogenomics. Some of her methods include Multifactor Dimensionality Reduction (MDR), the Analysis Tool for Heritable and Environmental Network Associations (ATHENA), and the Biosoftware suite for annotating/ filtering variants and genomic regions as well as building models of biological relevance for gene-gene interactions and rare-variant burden/dispersion tests. Dr. Ritchie has over 15 years of experience in the analysis of complex data and has authored over 250 publications. Dr. Ritchie has received several awards and honors, including selection as a Genome Technology Rising Young Investigator in 2006, an Alfred P. Sloan Research Fellow in 2010, a KAVLI Frontiers of Science fellow by the National Academy of Science from 2011-2014, and she was named one of the most highly cited researchers in her field by Thomson Reuters in 2014. Dr. Ritchie has extensive experience in all aspects of genetic epidemiology and translational bioinformatics as it relates to human genomics. She also has extensive expertise in dealing with big data and complex analysis including GWAS, next-generation sequencing, data integration of meta-dimensional omics data, Phenome-wide Association Studies (PheWAS), and development of data visualization approaches.

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