Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis: PEXIVAS

Study Findings: This was the largest international clinical trial performed in AAV (GPA and MPA). The study found that the use of plasma exchange does not improve survival or risk of end-stage renal disease. Compared to standard doses of prednisone, a more rapid taper of prednisone is just as effective and safer (fewer serious infections) than plasma exchange. View Publication.

ClinicalTrials.gov ID: NCT00987389

Study Dates: 2012-2019

Disease(s): Granulomatosis with Polyangiitis (GPA), Microscopic Polyangiitis (MPA)