Pilots

The Penn Mental Health AIDS Research Center (PMHARC) Developmental Award Program


About our Pilot Projects Program

The Developmental Core (Core B) of the Penn Mental Health AIDS Research Center (PMHARC) seeks to help build an integrated research infrastructure that can stimulate new research and support investigators as they design and implement innovative biological and behavioral studies on the treatment of mental illness among individuals with HIV/AIDS, in part through the funding of short term (one-year) pilot projects.  The particular focus of Core B is on the development of new investigators, transitional investigators and collaborations that have the capacity to develop and test innovative, integrated treatments to optimize psychiatric, behavioral, and medical outcomes and to achieve a better understanding of the biological, psychological, and behavioral mechanisms underlying these combined illnesses and treatments. 

Concordant with the mission of the PMHARC, pilot funds will support: 1) new faculty members who are beginning their research careers in mental health and HIV research, 2) investigators with established research programs who are transitioning to HIV and mental health research, and, 3) established AIDS investigators who have not directed their research at issues of psychiatric disorder or the treatment of mental illness.

Funded Pilots

2021 Pilots

  • The Role of PrEP-Related Stigma In PrEP Persistence among Young Black and Latinx Sexual and Gender Minorities  Dovie Watson, MD, MSCE (Penn Medicine), José Bauermeister, PhD, MPH (Nursing), Robert Gross, MD, MSCE (Penn Medicine)
  • Integration of Medication-Assisted Treatment and HIV Prevention Strategies Among Publicly-Insured Adolescents and Young Adults Living with Opioid Use Disorders in Philadelphia  Maria Cristina Herrera, MD (CHOP) and Nadia Dowshen, MD, MSHP (CHOP)
  • Immune dysregulation and neurodegeneration in adolescent SIV infection: radiographic and neuropathologic correlates  Jennifer McGuire MD MSCE (CHOP), Judith Grinspan, PhD (CHOP), Steven Douglas, MD (CHOP), Kelly Jordan-Scuitto, PhD (School of Dental Medicine)
  • Identification of molecular signature of HIV infected cells in CNS using single cell multi-omics technology  Yijing Su, PhD (Neuroscience) and Kelly Jordan-Sciutto, PhD (School of Dental Medicine)
  • Mental Health, Substance Use Disorder, and HIV Care Re-engagement among People Living with HIV Involved in the Criminal Justice System  Daniel Teixeria da Silva, MD (Penn Medicine), José Bauermeister, PhD, MPH (Nursing), Christina Kang-Yi, PhD (Penn Medicine), David Mandell, ScD (Psychiatry), Bruce Herdman, PhD, MBA (Philadelphia Department of Prisons), Evan Anderson, JD, PhD (Nursing and Penn Medicine)

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2020 Pilots

  • Understanding Participant Experience in the BEAT-HIV PEG-IFN +/- Broadly Neutralizing Antibodies Clinical Trial. Fran Barg, PhD, MEd (Family Medicine and Community Health),   Katharine Rendle, PhD (Family Medicine and Community Health)
  • Exploring the role of working memory difficulties in repetitive negative thinking, anxiety and depression, and medication adherence in HIV-positive adults. Keith Bredemeier, PhD (Psychiatry) and J. Cobb Scott, PhD (Psychiatry)
  • Use of Perceptual Mapping to Produce a PrEP Communication Strategy for Young Trans Women. Marné Castillo, PhD, Med (CHOP), Sarah Bauerle Bass, PhD, MPH (Temple University College of Public Health), Sarah Wood, MD (CHOP)
  • Supporting PrEP Initiation and Mental Health Screening in Community Care Settings with Automated, Proactive Text Messaging. Krisda Chaiyachati, MD, MPH, MSHP (Penn Medicine), Helen Koenig, MD, MPH (Penn Medicine), Natalie Lee, MD, MPH (Penn Medicine)
  • Computational design of novel antagonists for the Neurokinin-1 receptor. Cesar de la Fuente, PhD, MSc (Psychiatry, Bioengineering, Microbiology), Steven D. Douglas, MD (CHOP)
  • Preventing new HIV infection among women with and without mental illness comorbidity. Jessica Fishman, PhD (Annenberg School of Communication and Psychiatry), David Mandell, ScD (Psychiatry), Sarita Sonalkar, MD, MPH (Penn Medicine), Helen Koenig, MD, MPH (Penn Medicine)
  • Neural correlates of neurocognition associated with adherence to antiretroviral therapy. Paul Regier, PhD (Psychiatry), Anne M. Teitelman, PhD, CRNP (Nursing), Anna Rose Childress, PhD, MA (Psychiatry), Hasan Ayaz, PhD, MS (Drexel University School of Biomedical Engineering)
  • Opioid Use Disorder, Human Immunodeficiency Virus, and Neuroinflammation.  Reagan Wetherill, PhD, MA (Psychiatry), Henry Kranzler, MD (Psychiatry), Rebecca L. Ashare (Psychiatry), Jacob Dubroff, MD, PhD (Penn Medicine)

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2019 Pilots

  • Differences in nicotine metabolism in HIV positive individuals on antiretroviral therapy. Cedric Bien-Gund, MD (Penn Medicine) and Robert Gross, MD, MSCE (Penn Medicine)
  • Burden of Chronic conditions among persons with comorbid HIV/AIDS and mental illness. Sumedha Chhatre, PhD (Penn Psychiatry) and George Woody, MD (Penn Psychiatry)
  • "Exploring the relationship between gut microbiome alterations, posttraumatic stress disorder, and viral load suppression in HIV+ individuals". Sara Kornfield, PhD (Penn Psychiatry) and Brendan Kelly, MD, MSCE (Penn Medicine)
  • Cellular biomarkers of innate immunity in peripheral blood leukocytes of adolescents with Major Depressive Disorder. Tami Benton, MD (CHOP) and Sergein Spitsin, PhD (CHOP)
  • Using Natural Language Processing to Identify Depression in Patients with HIV. Lyle Ungar, PhD (CHOP) Paul Crits-Cristoph (Penn Psychiatry), and Brenda Curtis, PhD, MsPH (NIH)

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2018 Pilots

  • Expanding an adapted adolescent friendship bench to explore substance use in youth living with HIV and Youth At Risk for HIV acquisition. Merrian Brooks, DO, MS (CHOP) and Elizabeth Lowenthal, MD, MSCE (CHOP)
  • Depression as a determinant factor to immune cell activation and HIV infection in persons who inject drugs. Krystal Colón-Rivera, PhD (Wistar Institute) and Luis Montaner, DVM, PhD (Wistar Institute)
  • Understanding the significance of cardiac arrhythmias detected by continuous, non-invasive monitoring in HIV infected smokers. Rajat Deo, MD, MTR (Penn Medicine) and Rebecca Ashare, PhD (Penn Psychiatry)
  •  HIV/AIDS knowledge, risks, and stigma among people with mental disorders in rural China. Yin-Ling Irene Wong, PhD, MA (Penn Social Policy and Practice and Psychiatry)

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2017 Pilots

  • Sex Differences in Synaptophagy of Human Neurons by HIV-exposed Human Microglia. Stewart Anderson, MD (CHOP) and Kelly Jordan-Sciutto, PhD (Penn Medicine)
  • Prevalence and Correlates of Suicidal Ideation and Behaviors in Patients with Concomitant HIV and Chronic Pain. Martin Cheatle, PhD (Penn Psychiatry), Cecile Denis, PhD (Penn Psychiatry), Michelle Naps, PhD (Veterans Administration)
  • Adipose inflammation in lipodystrophy and metabolic dysfunction. David Hill, MD, PhD (CHOP) and Mitchell Lazar, MD, PhD (Penn Medicine)
  • Depression and Social Support along the PrEP Care Continuum. Sarah Wood, MD (CHOP) and Ian Frank, MD (Penn Medicine)

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2016 Pilots

  • Repurposing Metformin to Attenuate Nicotine Withdrawal among HIV-infected Smokers.  (Rebecca Ashare, PhD (Penn Psychiatry) Robert Schnoll, PhD (Penn Psychiatry) Caryn Lerman, PhD (Penn Psychiatry) Frank Leone, MD (Penn Medicine))
  • NS2359 in HAND.  (Wade Berrettini, MD, PhD (Penn Psychiatry))
  • Nicotinic receptor mechanisms in HIV-associated depression. (Mariella De Biasi, PhD (Penn Psychiatry) Dennis Kolson, MD, PhD (Penn Neurology))
  • Prevalence of cardiovascular risk in HIV positive psychiatric patients in Botswana (Mentor: Robert Gross, MD, MSCE (Penn Medicine)  Billy Tsima, MBBCh (University of Botswana, Family Medicine, Gabarone, Botswana) Mosepele Mosepele, MBBCh (University of Botswana, Medicine, Gabarone, Botswana) Philip Opondo, MBCHB, MMed (University of Botswana, Psychiatry, Gabarone, Botswana) Warren Bilker, PhD (Penn Biostatistics and Epidemiology))
  • Brain and behavioral impact of safe sex public service announcements on HIV infected adolescents.  (An-Li Wang, PhD (Penn Psychiatry)  Elizabeth Lowenthal, MD, MSCE (Penn Biostatistics and Epidemiology and Pediatrics, CHOP) Helen Koenig, MD (Penn Medicine))

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2015 Pilots

  • Understanding Causal Pathways Between SMI Symptoms and HIV Risk Behaviors.  (Fran Barg, PhD, MEd (Family Medicine and Community Health), Puneet Sahota, MD, PhD (Psychiatry), Chelsea Voytek, PhD (c) (Psychiatry))
  • Motivational Anhedonia as a Target of Intervention for HIV+ Individuals with Schizophrenia or Depression. (Mary Beth Gibbons, PhD (Psychiatry), Paul Crits Christoph, PhD (Psychiatry), Robert Gross, MD, MSCE (Medicine/ID and Epidemiology))
  • HIV Related Outcomes and Psychosocial Risk Factors for Depression Among HIV+ Pregnant Women in Philadelphia.  (John B. Jemmott III, PhD (Annenberg School of Communication and Psychiatry), Florence Momplaisir, MD, MSHP (Temple University- Infectious Disease); Kathleen Brady, MD (Medical Epidemiologist, Philadelphia Department of Public Health), Pamela Geller, PhD(Psychology and Public Health OB/GYN), Emily Anderson, BS (Student MPH))
  • Neuroinflammation and Dysregulation of the Antioxidant Response in HIV+ Individuals with Depression.  (Dennis L. Kolson, MD, PhD (Neurology), Stephanie A. Cross, MD, PhD (Psychiatry))
  • Developing and Validating Culture-Specific Measures of Stigma of HIV and Mental Illness in Botswana and the United States. (Philip Opondo, MBCHB(University of Botswana- Psychiatry) Ari Ho-Foster, MSc (Medicine) Morekwe Selemogwe, PhD (University of Botswana-Psychology), Seipone Mphele, PhD (University of Botswana-Psychology), Lawrence Yang, PhD (Mailman ? School of Public Health), Michael Blank, PhD (Psychiatry))
  • Prevalence and Type of Psychiatric Diagnoses Among Hospitalized Patients with HIV Infection. (Sabrina A. Poole, Psy.D (Psychiatry), George Woody, MD (Psychiatry))
  • A Brief Computerized Battery for Assessing HIV-Associated Neurocognitive Disorders: Validation and Relation to Plasma Biomarkers. (J. Cobb Scott, PhD (Psychiatry) Ruben C. Gur, PhD (Psychiatry)
  • Metabolomics and Lipidomics Analysis of Blood Metabolites from HIV+ Patients Treated for Insomnia with Comorbid Depression. (Aalim Weljie, PhD (Systems Pharmacology and Translational Therapeutics), Matt Kayser, MD, PhD (Psychiatry))
  • Stress Reduction Training to Target Psychological and Pathophysiological Mechanisms Implicated in HIV, Depression, and Co-Morbid Inflammatory Conditions. (Jeffrey M. Greeson, PhD (Psychiatry), Michael Thase, MD(Psychiatry))

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2014 Pilots

  • CSF and Plasma sCD163, FABP3 and sIR as Biomarkers of Neuropsychiatric Impairment in HIV-Seropositive Women (Steven Arnold, MD (Psychiatry), Valerie E. Wojna, MD (Neurology, University of Puerto Rico), Steven D. Douglas, MD (CHOP))
  • Does the Severity of Substance Use Disorders Affect Neurocognitive Functioning of HIV+ Patients? (Donna Coviello, PhD (Psychiatry), George Woody, PhD (Psychiatry/Addictions))
  • Barriers to Engagement and Retention in Care among HIV+ Transgender Youth with Psychiatric Co-Morbidities (Nadia L. Dowshen, MD (Pediatrics, CHOP), Frances K. Barg, PhD, MEd (Family Medicine and Community Health), Marne Castillo, PhD, MEd (Connect to Protect CHOP), Benoit Dubé, MD (Psychiatry), Linda A. Hawkins, PhD (Gender and Sexuality Development Clinic, CHOP))
  • The Impact of Post-Traumatic Stress Disorder on HIV care Retention (Carmen McLean, PhD (Psychiatry), Edna Foa, PhD (Psychiatry))
  • A Pilot study of Lifestyle Modification for Weight Loss in Persons with Obesity, HIV/AIDS and Major Depression (David Sarwer, PhD (Psychiatry), Lucy Hemsley-Faulconbridge, PhD (Psychiatry), Rexford S. Ahima, MD, PhD (Medicine))
  • Computer-Assisted Cognitive Behavior Therapy for Depressed, HIV+ People Taking Antiviral Medications (Michael Thase, MD (Psychiatry))

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2013 Pilots

  • Mid-Life Cognitive Function in HIV+ Individuals: Impact of Endocrine and Immune Status (C. Neill Epperson, MD (Psychiatry), Liisa Hantsoo, PhD (Psychiatry))
  • Treatment of Insomnia with Zaleplon in HIV Positive Patients with Comorbid Depression (Matthew Kayser, MD, PhD (Psychiatry), Michael Thase, MD (Psychiatry))
  • The Impact of Personal Relevance and Depression on Brain and Behavioral Effects of HIV Prevention PSAs in HIV-Positive MSM (Daniel Langleben, MD (Psychiatry), An-Li Wang, D.Phil (Annenberg))
  • Predictors of HIV-Associated Psychiatric Distress and Neurocognitive Decline in a Multi-Ethnic Pediatric Sample (Iman Martin, PHD, MPH, M.Sc. (Psychiatry), Ruben Gur, PhD (Psychiatry), Raquel Gur, MD, PhD (Psychiatry))
  • Immune and Neuroimaging Biomarker Correlations between Depression and HIV-Associated Neurocognitive Disorders in HIV-Infected Youth (Jennifer McGuire, MD (Neurology, CHOP), Brenda Banwell, MD (Neurology, CHOP), Tami Benton, MD (Psychiatry, CHOP), Linda Hawkins, PhD, LPC (Pediatrics, CHOP))
  • Evaluation of the HIV Treatment Cascade for HIV-Infected Persons with Mental Illness (Baligh Yehia, MD, MPP, MSHP (Medicine/ID), Kathleen Brady, MD (Philadelphia Department of Public Health), Benoit Dube, MD (Psychiatry), Karen Glanz, PhD, MPH (Epidemiology and Nursing), Robert Gross, MD, MSCE (Medicine/ID and Epidemiology))

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