Penn Neurodegeneration Genomics Center

Welcome to the Penn Neurodegeneration Genomics Center (PNGC), part of the Department of Pathology and Laboratory Medicine, in the Perelman School of Medicine, at the University of Pennsylvania.

PNGC studies genetics of Alzheimer’s Disease and other related dementia. Our researchers apply high throughput genotyping and sequencing technologies to analyze tens of thousands of genomes and find novel genes.  New experimental approaches, algorithms, and databases are developed in order to translate these findings into biological knowledge about the disease and new directions for drug discovery and preventive strategies.

PNGC supports the following scientific and educational activities: 

  • Lead large genetics/genomics collaborations
  • Research new experimental and computational approaches
  • Develop computational/experimental resources for nationwide and international projects
  • Provide education and training for next generation scientists in related area

News and Events

July 17, 2017 — Newly Discovered Gene Variants Link Innate Immunity and Alzheimer’s Disease
PHILADELPHIA – Three new gene variants, found in a genome wide association study of Alzheimer’s disease (AD), point to the brain’s immune cells in the onset of the disorder. Read more..

May 15, 2017 — Penn Medicine's Alzheimer's Genetics Data Storage Site Receives Five-Year Renewal to total $7.7 Million
PHILADELPHIA—Penn Medicine’s Alzheimer’s disease genetics data repository has received a five-year funding renewal from the National Institute on Aging (NIA) of the National Institutes of Health. The award is expected to total $7.7 million over five years. Read more..


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