Perelman School of Medicine at the University of Pennsylvania

The Roth Laboratory

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Welcome to the Roth Lab

DNA Repair, Cancer Genetics, and Cancer Genomics

Understanding DNA double–strand break repair and genome rearrangements through V(D)J recombination. 

The Roth Lab studies the interface between V(D)J recombination and DNA repair, with a particular interest in the functions of the RAG proteins, the mechanisms of programmed gene rearrangements during lymphocyte differentiation, and the contribution of these rearrangements to lymphoid neoplasms.