Systems Pharmacology and Translational Therapeutics involves the discovery of new drugs, the investigation of how drugs work and the use of drugs to probe mechanisms of disease. But pharmacology also involves the elucidation and manipulation of macromolecular structures, the analysis of regulatory mechanisms in cell biology and development, and the translation of this information into clinical research. Emerging concepts in drug development also involve in vivo targeting or ex vivo engineering of Immune Cells to "retrain" the human immune system to achieve control of disease and more optimal health. Thus, the science of pharmacology spans the most fundamental aspects of basic research, through transgenic animal models, to clinical investigation.

Pharmacology at Penn addresses all of these issues in an exciting, collegial and interactive environment. To learn more visit our welcome page.

Institute for Structural Biology

I am delighted to announce the establishment of the Institute for Structural Biology established in the Perelman School of Medicine (PSOM) led by Dr. Vera Moiseenkova-Bell, Professor at the Department of Systems Pharmacology and Translational Therapeutics. The Institute for Structural Biology at the Perelman School of Medicine focuses on the study of proteins, nucleic acids, and other biomolecules, with the goal of understanding how they function and interact with one another in living organisms. By using advanced structural biology and computational techniques, the Institute aims to unravel the complex structures and dynamics of these molecules and provide insights into how they contribute to disease and other biological processes.

For more information on instrumentation that will be available in the Structural Biology Program, please see information on this website: https://www.med.upenn.edu/electronmicroscopyresourcelab/.