Publications

April

• Expression and processing of mature human frataxin after gene therapy in mice. Rojsajjakul T, Selvan N, De B, Rosenberg JB, Kaminsky SM, Sondhi D, Janki P, Crystal RG, Mesaros C, Khanna R, Blair IA. Sci Rep. 2024 Apr 10;14(1):8391. doi: 10.1038/s41598-024-59060-0. PMID: 38600238 
• Frataxin analysis using triple quadrupole mass spectrometry: application to a large heterogeneous clinical cohort. Lynch DR, Rojsajjakul T, Subramony SH, Perlman SL, Keita M, Mesaros C, Blair IA. J Neurol. 2024 Apr;271(4):1844-1849. doi: 10.1007/s00415-023-12118-x. Epub 2023 Dec 8. PMID: 38063871
• Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass. Greenwood JC, Talebi FM, Jang DH, Spelde AE, Gordon EK, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JGT, Brenner JS, Muzykantov VR, Bakker J, Abella BS. Crit Care Med. 2024 Apr 5. doi: 10.1097/CCM.0000000000006289. Online ahead of print.PMID: 38578158
• Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity. Sosnoski HM, Posey AD Jr. Cell Stem Cell. 2024 Apr 4;31(4):437-438. doi: 10.1016/j.stem.2024.03.006. PMID: 38579681

• ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes. Lu Z, McBrearty N, Chen J, Tomar VS, Zhang H, De Rosa G, Tan A, Weljie AM, Beiting DP, Miao Z, George SS, Berger A, Saggu G, Diehl JA, Koumenis C, Fuchs SY. Cell Metab. 2024 Apr 10:S1550-4131(24)00122-0. doi: 10.1016/j.cmet.2024.04.002. Online ahead of print. PMID: 38604169

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  Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants. Johnston TS, Li SH, Painter MM, Atkinson RK, Douek NR, Reeg DB, Douek DC, Wherry EJ, Hensley SE. Immunity. 2024 Apr 9;57(4):912-925.e4. doi: 10.1016/j.immuni.2024.02.017. Epub 2024 Mar 14. PMID: 38490198

March

• p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs. Grit JL, McGee LE, Tovar EA, Essenburg CJ, Wolfrum E, Beddows I, Williams K, Sheridan RTC, Schipper JL, Adams M, Arumugam M, Vander Woude T, Gurunathan S, Field JM, Wulfkuhle J, Petricoin EF 3rd, Graveel CR, Steensma MR. Oncogene. 2024 Mar 13. doi: 10.1038/s41388-024-03000-9. Online ahead of print. PMID: 38480916
• Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke. Nong J, Glassman PM, Shuvaev VV, Reyes-Esteves S, Descamps HC, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Gong X, Brysgel TV, Tan AW, Woolfork AG, Weljie A, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA. Mol Ther. 2024 Mar 7:S1525-0016(24)00145-X. doi: 10.1016/j.ymthe.2024.03.004. Online ahead of print. PMID: 38454606
• Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system. Parhiz H, Shuvaev VV, Li Q, Papp TE, Akyianu AA, Shi R, Yadegari A, Shahnawaz H, Semple SC, Mui BL, Weissman D, Muzykantov VR, Glassman PM. Mol Ther Nucleic Acids. 2024 Mar 18;35(2):102175. doi: 10.1016/j.omtn.2024.102175. eCollection 2024 Jun 11. PMID: 38576454 
• Circadian regulation of lung repair and regeneration. Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S. JCI Insight. 2024 Mar 8;9(5):e179745. doi: 10.1172/jci.insight.179745. PMID: 38456509 
• Prostanoids in Cardiac and Vascular Remodeling. Ricciotti E, Haines PG, Chai W, FitzGerald GA. Arterioscler Thromb Vasc Biol. 2024 Mar;44(3):558-583. doi: 10.1161/ATVBAHA.123.320045. Epub 2024 Jan 25. PMID: 38269585 
• Identification of the growth cone as a probe and driver of neuronal migration in the injured brain. Nakajima C, Sawada M, Umeda E, Takagi Y, Nakashima N, Kuboyama K, Kaneko N, Yamamoto S, Nakamura H, Shimada N, Nakamura K, Matsuno K, Uesugi S, Vepřek NA, Küllmer F, Nasufović V, Uchiyama H, Nakada M, Otsuka Y, Ito Y, Herranz-Pérez V, García-Verdugo JM, Ohno N, Arndt HD, Trauner D, Tabata Y, Igarashi M, Sawamoto K. Nat Commun. 2024 Mar 9;15(1):1877. doi: 10.1038/s41467-024-45825-8. PMID: 38461182 
• Immunologic predictors of vaccine responsiveness in patients with lymphoma and CLL. Chong EA, Kumashie KG, Chong ER, Fabrizio J, Gupta A, Svoboda J, Barta SK, Walsh KM, Napier EB, Lundberg RK, Nasta SD, Gerson JN, Landsburg DJ, Gonzalez J, Gaano A, Weirick ME, McAllister CM, Awofolaju M, John GN, Kammerman SC, Novaceck J, Pajarillo R, Lundgreen KA, Tanenbaum N, Gouma S, Drapeau EM, Adamski S, D'Andrea K, Pattekar A, Hicks A, Korte S, Sharma H, Herring S, Williams JC, Hamilton JT, Bates P, Hensley SE, Prak ETL, Greenplate AR, Wherry EJ, Schuster SJ, Ruella M, Vella LA. J Infect Dis. 2024 Mar 4:jiae106. doi: 10.1093/infdis/jiae106. Online ahead of print. PMID: 38437622
• Neonatal CD8+ T Cells Resist Exhaustion during Chronic Infection. Maymí VI, Zhu H, Jager M, Johnson S, Getchell R, Casey JW, Grenier JK, Wherry EJ, Smith NL, Grimson A, Rudd BD. J Immunol. 2024 Mar 1;212(5):834-843. doi: 10.4049/jimmunol.2300396. PMID: 38231127
• Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial. Bagley SJ, Binder ZA, Lamrani L, Marinari E, Desai AS, Nasrallah MP, Maloney E, Brem S, Lustig RA, Kurtz G, Alonso-Basanta M, Bonté PE, Goudot C, Richer W, Piaggio E, Kothari S, Guyonnet L, Guerin CL, Waterfall JJ, Mohan S, Hwang WT, Tang OY, Logun M, Bhattacharyya M, Markowitz K, Delman D, Marshall A, Wherry EJ, Amigorena S, Beatty GL, Brogdon JL, Hexner E, Migliorini D, Alanio C, O'Rourke DM. Nat Cancer. 2024 Mar;5(3):517-531. doi: 10.1038/s43018-023-00709-6. Epub 2024 Jan 12. PMID: 38216766 

February

• Impact of OPRM1 (Mu-opioid Receptor Gene) A112G Polymorphism on Dual Oxycodone and Cocaine Self-administration Behavior in a Mouse Model. Zhang Y, Randesi M, Blendy JA, Kreek MJ, Butelman ER. Neuroscience. 2024 Feb 16;539:76-85. doi: 10.1016/j.neuroscience.2024.01.002. Epub 2024 Jan 10. PMID: 38211933
• The Paraventricular Thalamic Nucleus and Its Projections in Regulating Reward and Context Associations. McDevitt DS, Wade QW, McKendrick GE, Nelsen J, Starostina M, Tran N, Blendy JA, Graziane NM. eNeuro. 2024 Feb 15;11(2):ENEURO.0524-23.2024. doi: 10.1523/ENEURO.0524-23.2024. Print 2024 Feb. PMID: 38351131
• Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma. Riscal R, Gardner SM, Coffey NJ, Carens M, Mesaros C, Xu JP, Xue Y, Davis L, Demczyszyn S, Vogt A, Olia A, Finan JM, Godfrey J, Schultz DC, Blair IA, Keith B, Marmorstein R, Skuli N, Simon MC. Cancer Res. 2024 Feb 28. doi: 10.1158/0008-5472.CAN-23-0821. Online ahead of print. PMID: 38417134
• Neural Network Connectivity Following Opioid Dependence is Altered by a Common Genetic Variant in the µ-Opioid Receptor, OPRM1 A118G. Xie Y, Brynildsen JK, Windisch K, Blendy JA. J Neurosci. 2024 Feb 7;44(6):e1492232023. doi: 10.1523/JNEUROSCI.1492-23.2023. PMID: 38124015
• Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles. Rogers SA, Heller EA, Corder G. bioRxiv [Preprint]. 2024 Feb 4:2024.02.04.578811. doi: 10.1101/2024.02.04.578811. PMID: 38352491 
• Structural mechanism of TRPV5 inhibition by econazole. De Jesús-Pérez JJ, Gabrielle M, Raheem S, Fluck EC, Rohacs T, Moiseenkova-Bell VY. Structure. 2024 Feb 1;32(2):148-156.e5. doi: 10.1016/j.str.2023.11.012. Epub 2023 Dec 22. PMID: 38141613
• Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions. Omo-Lamai S, Zamora ME, Patel MN, Wu J, Nong J, Wang Z, Peshkova A, Majumder A, Melamed JR, Chase LS, Essien EO, Weissman D, Muzykantov VR, Marcos-Contreras OA, Myerson JW, Brenner JS. Adv Mater. 2024 Feb 23:e2312026. doi: 10.1002/adma.202312026. Online ahead of print. PMID: 38394670
• SlumberNet: deep learning classification of sleep stages using residual neural networks. Jha PK, Valekunja UK, Reddy AB. Sci Rep. 2024 Feb 27;14(1):4797. doi: 10.1038/s41598-024-54727-0.PMID: 38413666 
• Efficient engineering of human and mouse primary cells using peptide-assisted genome editing. Zhang Z, Baxter AE, Ren D, Qin K, Chen Z, Collins SM, Huang H, Komar CA, Bailer PF, Parker JB, Blobel GA, Kohli RM, Wherry EJ, Berger SL, Shi J. Nat Biotechnol. 2024 Feb;42(2):305-315. doi: 10.1038/s41587-023-01756-1. Epub 2023 Apr 24. PMID: 37095348

January

• Analysis of NIH K99/R00 awards and the career progression of awardees. Woitowich NC, Hengel SR, Solis C, Vilgalys TP, Babdor J, Tyrrell DJ. Elife. 2024 Jan 19;12:RP88984. doi: 10.7554/eLife.88984. PMID: 38240745 
• High-throughput single-cell, single-mitochondrial DNA assay using hydrogel droplet microfluidics. Park J, Kadam PS, Atiyas Y, Chhay B, Tsourkas A, Eberwine JH, Issadore DA. bioRxiv [Preprint]. 2024 Jan 31:2024.01.29.577854. doi: 10.1101/2024.01.29.577854. PMID: 38352577 
• Age-regulated cycling metabolites are relevant for behavior. Schwarz JE, Sengupta A, Guevara C, Barber AF, Hsu CT, Zhang SL, Weljie A, Sehgal A. Aging Cell. 2024 Jan 11:e14082. doi: 10.1111/acel.14082. Online ahead of print. PMID: 38204362 
• FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma. Anderson TM, Chang BH, Huang AC, Xu X, Yoon D, Shang CG, Mick R, Schubert E, McGettigan S, Kreider K, Xu W, Wherry EJ, Schuchter LM, Amaravadi RK, Mitchell TC, Farwell MD. Clin Cancer Res. 2024 Jan 24:OF1-OF10. doi: 10.1158/1078-0432.CCR-23-2390. Online ahead of print. PMID: 38263597

December 2023

• Metabolic pathway analysis using stable isotopes in patients with cancer. Bartman CR, Faubert B, Rabinowitz JD, DeBerardinis RJ. Nat Rev Cancer. 2023 Dec;23(12):863-878. doi: 10.1038/s41568-023-00632-z. Epub 2023 Oct 31. PMID: 37907620 Review.
• Chimeric kinase ALK induces expression of NAMPT and selectively depends on this metabolic enzyme to sustain its own oncogenic function. Zhang Q, Basappa J, Wang HY, Nunez-Cruz S, Lobello C, Wang S, Liu X, Chekol S, Guo L, Ziober A, Nejati R, Shestov A, Feldman M, Glickson JD, Turner SD, Blair IA, Van Dang C, Wasik MA. Leukemia. 2023 Dec;37(12):2436-2447. doi: 10.1038/s41375-023-02038-0. Epub 2023 Sep 29. PMID: 37773266
• Forks in the road for CAR T and CAR NK cell cancer therapies. Dagher OK, Posey AD Jr. Nat Immunol. 2023 Dec;24(12):1994-2007. doi: 10.1038/s41590-023-01659-y. Epub 2023 Nov 27. PMID: 38012406

November

• Effective Prevention of Arterial Thrombosis with Albumin-Thrombin Inhibitor Conjugates. Marcos-Contreras OA, Myerson JW, Nong J, Brenner JS, Muzykantov VR, Glassman PM. Mol Pharm. 2023 Nov 6;20(11):5476-5485. doi: 10.1021/acs.molpharmaceut.3c00325. Epub 2023 Oct 12. PMID: 37823223
• Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples. O'Donnell VB, Schebb NH, Milne GL, Murphy MP, Thomas CP, Steinhilber D, Gelhaus SL, Kühn H, Gelb MH, Jakobsson PJ, Blair IA, Murphy RC, Freeman BA, Brash AR, FitzGerald GA. Nat Commun. 2023 Nov 9;14(1):7172. doi: 10.1038/s41467-023-41766-w. PMID: 37945602 
• Sleep deprivation and aging are metabolically linked across tissues. Sengupta A, Tudor JC, Cusmano D, Baur JA, Abel T, Weljie AM. Sleep. 2023 Nov 8;46(11):zsad246. doi: 10.1093/sleep/zsad246. PMID: 37738102
• Trimodal single-cell profiling reveals a novel pediatric CD8αα⁺ T cell subset and broad age-related molecular reprogramming across the T cell compartment. Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li XJ, Bumol TF, Wherry EJ, Torgerson TR, Vella LA, Henrickson SE, Skene PJ, Gustafson CE. Nat Immunol. 2023 Nov;24(11):1947-1959. doi: 10.1038/s41590-023-01641-8. Epub 2023 Oct 16. PMID: 37845489

• One-carbon unit supplementation fuels tumor-infiltrating T cells and augments checkpoint blockade. Xu X, Chen Z, Bartman CR, Xing X, Olszewski K, Rabinowitz JD. bioRxiv. 2023 Nov 3:2023.11.01.565193. doi: 10.1101/2023.11.01.565193. Preprint. PMID: 37961420 Free PMC article.

• A century of the Warburg effect. Thompson CB, Vousden KH, Johnson RS, Koppenol WH, Sies H, Lu Z, Finley LWS, Frezza C, Kim J, Hu Z, Bartman CR. Nat Metab. 2023 Nov;5(11):1840-1843. doi: 10.1038/s42255-023-00927-3.PMID: 37990075 No abstract available.

• A T cell receptor β chain-directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity. Hsu J, Donahue RN, Katragadda M, Lowry J, Huang W, Srinivasan K, Guntas G, Tang J, Servattalab R, Moisan J, Tsai YT, Stoop A, Palakurthi S, Chopra R, Liu K, Wherry EJ, Su Z, Gulley JL, Bayliffe A, Schlom J. Sci Transl Med. 2023 Nov 29;15(724):eadi0258. doi: 10.1126/scitranslmed.adi0258. Epub 2023 Nov 29. PMID: 38019931

• A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples. Hou W, Ji Z, Chen Z, Wherry EJ, Hicks SC, Ji H. Nat Commun. 2023 Nov 10;14(1):7286. doi: 10.1038/s41467-023-42841-y. PMID: 37949861

• Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples. O'Donnell VB, Schebb NH, Milne GL, Murphy MP, Thomas CP, Steinhilber D, Gelhaus SL, Kühn H, Gelb MH, Jakobsson PJ, Blair IA, Murphy RC, Freeman BA, Brash AR, FitzGerald GA. Nat Commun. 2023 Nov 9;14(1):7172. doi: 10.1038/s41467-023-41766-w. PMID: 37945602 

• CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential. Lu Y, Lee J, Li J, Allu SR, Wang J, Kim H, Bullaughey KL, Fisher SA, Nordgren CE, Rosario JG, Anderson SA, Ulyanova AV, Brem S, Chen HI, Wolf JA, Grady MS, Vinogradov SA, Kim J, Eberwine J. Nat Commun. 2023 Nov 14;14(1):7346. doi: 10.1038/s41467-023-43158-6. PMID: 37963886

• Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response.Hurwitz SN, Jung SK, Kobulsky DR, Fazelinia H, Spruce LA, Pérez EB, Groen N, Mesaros C, Kurre P. Blood. 2023 Nov 16;142(20):1708-1723. doi: 10.1182/blood.2023022147. PMID: 37699202

• RIFM fragrance ingredient safety assessment, phenylacetaldehyde 2,4-dihydroxy-2-methylpentane acetal, CAS Registry Number 67633-94-7. Api AM, Belsito D, Botelho D, Bruze M, Burton GA Jr, Cancellieri MA, Chon H, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y. Food Chem Toxicol. 2023 Nov 30:114279. doi: 10.1016/j.fct.2023.114279. Online ahead of print. PMID: 38042278

• Low postoperative perfused vessel density is associated with increased soluble endothelial cell adhesion molecules during circulatory shock after cardiac surgery. Greenwood JC, Talebi FM, Jang DH, Spelde AE, Gordon EK, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JGT, Bakker J, Brenner JS, Muzykantov VR, Abella BS. Microvasc Res.2023 Nov;150:104595. doi: 10.1016/j.mvr.2023.104595. Epub 2023 Aug 22. PMID: 37619889

October

• Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini. Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. J Cell Sci. 2023 Oct 15;136(20):jcs261623. doi: 10.1242/jcs.261623. Epub 2023 Oct 19. PMID: 37855733 
• Quantification of human mature frataxin protein expression in nonhuman primate hearts after gene therapy. Rojsajjakul T, Hordeaux JJ, Choudhury GR, Hinderer CJ, Mesaros C, Wilson JM, Blair IA. Commun Biol. 2023 Oct 27;6(1):1093. doi: 10.1038/s42003-023-05472-z. PMID: 37891254
• Targeting Solid Cancers with a Cancer-Specific Monoclonal Antibody to Surface Expressed Aberrantly O-glycosylated Proteins Aasted MKM, Groen AC, Keane JT, Dabelsteen S, Tan E, Schnabel J, Liu F, Lewis HS, Theodoropulos C, Posey AD, Wandall HH. Mol Cancer Ther. 2023 Oct 2;22(10):1204-1214. doi: 10.1158/1535-7163.MCT-23-0221. PMID: 37451822 
• Photoactivated Protein Degrader for Optical Control of Synaptic Function. Ko T, Jou C, Grau-Perales AB, Reynders M, Fenton AA, Trauner D. ACS Chem Neurosci. 2023 Oct 4;14(19):3704-3713. doi: 10.1021/acschemneuro.3c00390. Epub 2023 Sep 15. PMID: 37712589 
• Serotonin reduction in post-acute sequelae of viral infection. Wong AC, Devason AS, Umana IC, Cox TO, Dohnalová L, Litichevskiy L, Perla J, Lundgren P, Etwebi Z, Izzo LT, Kim J, Tetlak M, Descamps HC, Park SL, Wisser S, McKnight AD, Pardy RD, Kim J, Blank N, Patel S, Thum K, Mason S, Beltra JC, Michieletto MF, Ngiow SF, Miller BM, Liou MJ, Madhu B, Dmitrieva-Posocco O, Huber AS, Hewins P, Petucci C, Chu CP, Baraniecki-Zwil G, Giron LB, Baxter AE, Greenplate AR, Kearns C, Montone K, Litzky LA, Feldman M, Henao-Mejia J, Striepen B, Ramage H, Jurado KA, Wellen KE, O'Doherty U, Abdel-Mohsen M, Landay AL, Keshavarzian A, Henrich TJ, Deeks SG, Peluso MJ, Meyer NJ, Wherry EJ, Abramoff BA, Cherry S, Thaiss CA, Levy M. Cell. 2023 Oct 26;186(22):4851-4867.e20. doi: 10.1016/j.cell.2023.09.013. Epub 2023 Oct 16. PMID: 37848036 
• CD8⁺ T cells in the cancer-immunity cycle. Giles JR, Globig AM, Kaech SM, Wherry EJ. Immunity. 2023 Oct 10;56(10):2231-2253. doi: 10.1016/j.immuni.2023.09.005. PMID: 37820583 
• Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection. Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, Giles JR, Skelly AN, Felley LE, McLaughlin M, Weaver J; Penn Medicine BioBank; Kuthuru O, Dougherty J, Adamski S, Long S, Kee M, Clendenin C, da Silva Antunes R, Grifoni A, Weiskopf D, Sette A, Huang AC, Rader DJ, Hensley SE, Bates P, Greenplate AR, Wherry EJ. Nat Immunol. 2023 Oct;24(10):1711-1724. doi: 10.1038/s41590-023-01613-y. Epub 2023 Sep 21. PMID: 37735592
• SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Proal AD, VanElzakker MB, Aleman S, Bach K, Boribong BP, Buggert M, Cherry S, Chertow DS, Davies HE, Dupont CL, Deeks SG, Eimer W, Ely EW, Fasano A, Freire M, Geng LN, Griffin DE, Henrich TJ, Iwasaki A, Izquierdo-Garcia D, Locci M, Mehandru S, Painter MM, Peluso MJ, Pretorius E, Price DA, Putrino D, Scheuermann RH, Tan GS, Tanzi RE, VanBrocklin HF, Yonker LM, Wherry EJ. Nat Immunol. 2023 Oct;24(10):1616-1627. doi: 10.1038/s41590-023-01601-2. Epub 2023 Sep 4. PMID: 37667052 

• Trimodal single-cell profiling reveals a novel pediatric CD8αα⁺ T cell subset and broad age-related molecular reprogramming across the T cell compartment. Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li XJ, Bumol TF, Wherry EJ, Torgerson TR, Vella LA, Henrickson SE, Skene PJ, Gustafson CE. Nat Immunol. 2023 Oct 16. doi: 10.1038/s41590-023-01641-8. Online ahead of print. PMID: 37845489

• CD8⁺ T cells in the cancer-immunity cycle. Giles JR, Globig AM, Kaech SM, Wherry EJ. Immunity. 2023 Oct 10;56(10):2231-2253. doi: 10.1016/j.immuni.2023.09.005. PMID: 37820583 

• Quantification of human mature frataxin protein expression in nonhuman primate hearts after gene therapy. Rojsajjakul T, Hordeaux JJ, Choudhury GR, Hinderer CJ, Mesaros C, Wilson JM, Blair IA. Commun Biol. 2023 Oct 27;6(1):1093. doi: 10.1038/s42003-023-05472-z. PMID: 37891254 

• Cell-Free DNA as a Biomarker in a Rodent Model of Chlorpyrifos Poisoning Causing Mitochondrial Dysfunction. Kao SH, Shofer FS, Greenwood JC, Alomaja O, Ranganathan A, Piel S, Mesaros C, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH. J Med Toxicol. 2023 Oct;19(4):352-361. doi: 10.1007/s13181-023-00956-0. Epub 2023 Jul 31. PMID: 37523031

• Targeting Solid Cancers with a Cancer-Specific Monoclonal Antibody to Surface Expressed Aberrantly O-glycosylated Proteins. Aasted MKM, Groen AC, Keane JT, Dabelsteen S, Tan E, Schnabel J, Liu F, Lewis HS, Theodoropulos C, Posey AD, Wandall HH. Mol Cancer Ther. 2023 Oct 2;22(10):1204-1214. doi: 10.1158/1535-7163.MCT-23-0221. PMID: 37451822 

• Mechanisms and physiological function of daily haemoglobin oxidation rhythms in red blood cells. Beale AD, Hayter EA, Crosby P, Valekunja UK, Edgar RS, Chesham JE, Maywood ES, Labeed FH, Reddy AB, Wright KP Jr, Lilley KS, Bechtold DA, Hastings MH, O'Neill JS. EMBO J. 2023 Oct 4;42(19):e114164. doi: 10.15252/embj.2023114164. Epub 2023 Aug 9. PMID: 37554073 

September

• Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types. Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC, Bennett ML, Blendy JA, Platt ML, Creasy KT, Renthal WR, Ramakrishnan C, Deisseroth K, Corder G. Nat Commun. 2023 Sep 13;14(1):5632. doi: 10.1038/s41467-023-41407-2. PMID: 37704594 

• Cell Type-Specific Whole-Genome Landscape of ΔFOSB Binding in the Nucleus Accumbens After Chronic Cocaine Exposure. Yeh SY, Estill M, Lardner CK, Browne CJ, Minier-Toribio A, Futamura R, Beach K, McManus CA, Xu SJ, Zhang S, Heller EA, Shen L, Nestler EJ. Biol Psychiatry. 2023 Sep 1;94(5):367-377. doi: 10.1016/j.biopsych.2022.12.021. Epub 2023 Jan 2. PMID: 36906500

• AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3β,17β-Diol. Detlefsen AJ, Mesaros CA, Duan L, Penning TM. Cancer Res Commun. 2023 Sep 19;3(9):1888-1898. doi: 10.1158/2767-9764.CRC-23-0235. PMID: 37772993 
• Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response. Hurwitz SN, Jung SK, Kobulsky DR, Fazelinia H, Spruce LA, Baltasar-Pérez E, Groen N, Mesaros C, Kurre P.  Blood. 2023 Sep 12:blood.2023022147. doi: 10.1182/blood.2023022147. Online ahead of print. PMID: 37699202
• Expansion of Anticomplement Therapy Indications from Rare Genetic Disorders to Common Kidney Diseases. Miwa T, Sato S, Golla M, Song WC. Annu Rev Med. 2023 Sep 5. doi: 10.1146/annurev-med-042921-102405. Online ahead of print. PMID: 37669567 

• Intrinsically disordered regions in TRPV2 mediate protein-protein interactions. Sanganna Gari RR, Tagiltsev G, Pumroy RA, Jiang Y, Blackledge M, Moiseenkova-Bell VY, Scheuring S. Commun Biol. 2023 Sep 22;6(1):966. doi: 10.1038/s42003-023-05343-7. PMID: 37736816

• Expansion of Anticomplement Therapy Indications from Rare Genetic Disorders to Common Kidney Diseases. Miwa T, Sato S, Golla M, Song WC. Annu Rev Med. 2023 Sep 5. doi: 10.1146/annurev-med-042921-102405. Online ahead of print. PMID: 37669567 

August

• Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches. Hetzler BE, Donthamsetti P, Peitsinis Z, Stanley C, Trauner D, Isacoff EY. J Am Chem Soc. 2023 Aug 16. doi: 10.1021/jacs.3c02735. Online ahead of print. PMID: 37586061
• Concise Synthesis of Glycerophospholipids. Mukhopadhyay TK, Trauner D. J Org Chem. 2023 Aug 4;88(15):11253-11257. doi: 10.1021/acs.joc.2c02096. Epub 2022 Nov 30. PMID: 36449029

July

• Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures. Nasr Z, Schoeps VA, Ziaei A, Virupakshaiah A, Adams C, Casper TC, Waltz M, Rose J, Rodriguez M, Tillema JM, Chitnis T, Graves JS, Benson L, Rensel M, Krupp L, Waldman AT, Weinstock-Guttman B, Lotze T, Greenberg B, Aaen G, Mar S, Schreiner T, Hart J, Simpson-Yap S, Mesaros C, Barcellos LF, Waubant E. J Neurol Neurosurg Psychiatry. 2023 Jul;94(7):518-525. doi: 10.1136/jnnp-2022-330713. Epub 2023 Feb 1. PMID: 36725329 
• The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR⁺CD8⁺ effector state, and its deletion improves checkpoint blockade. McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. Cell Rep. 2023 Jul 31;42(8):112905. doi: 10.1016/j.celrep.2023.112905. Online ahead of print. PMID: 37527035 

June

• Acyl-CoA thioesterase-2 facilitates β-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner. Bekeova C, Han JI, Xu H, Kerr E, Blackburne B, Lynch SC, Mesaros C, Murgia M, Vadigepalli R, Beld J, Leonardi R, Snyder NW, Seifert EL. bioRxiv. 2023 Jun 27:2023.06.27.546724. doi: 10.1101/2023.06.27.546724. Preprint. PMID: 37425757
• The enteric nervous system relays psychological stress to intestinal inflammation. Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA. Cell. 2023 Jun 22;186(13):2823-2838.e20. doi: 10.1016/j.cell.2023.05.001. Epub 2023 May 25. PMID: 37236193
• The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8⁺ T cells. Baxter AE, Huang H, Giles JR, Chen Z, Wu JE, Drury S, Dalton K, Park SL, Torres L, Simone BW, Klapholz M, Ngiow SF, Freilich E, Manne S, Alcalde V, Ekshyyan V, Berger SL, Shi J, Jordan MS, Wherry EJ. Immunity. 2023 Jun 13;56(6):1320-1340.e10. doi: 10.1016/j.immuni.2023.05.008. PMID: 37315535
• Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis. Meng H, Sengupta A, Ricciotti E, Mrčela A, Mathew D, Mazaleuskaya LL, Ghosh S, Brooks TG, Turner AP, Schanoski AS, Lahens NF, Tan AW, Woolfork A, Grant G, Susztak K, Letizia AG, Sealfon SC, Wherry EJ, Laudanski K, Weljie AM, Meyer NB, FitzGerald GA. bioRxiv. 2023 Jun 2:2023.06.02.543298. doi: 10.1101/2023.06.02.543298. Preprint. PMID: 37398323 
• To Isomerize or not to Isomerize? E/Z Isomers of Cyclic Azobenzene Derivatives and Their Reactivity Upon One-Electron Reduction. Glotz G, Knaipp K, Maier MS, Hüll K, Novak A, Kelterer AM, Griebenow T, Herges R, Trauner D, Gescheidt G. Chemistry. 2023 Jun 22;29(35):e202300146. doi: 10.1002/chem.202300146. Epub 2023 May 8. PMID: 37040130
• Development of Light-Activated LXR Agonists. Mukhopadhyay TK, Willems S, Arp CJ, Morstein J, Haake CT, Merk D, Trauner D. ChemMedChem. 2023 Jun 1;18(11):e202200647. doi: 10.1002/cmdc.202200647. Epub 2023 Jun 1. PMID: 36896647

May

• Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma. Shah PD, Huang AC, Xu X, Orlowski R, Amaravadi RK, Schuchter LM, Zhang P, Tchou J, Matlawski T, Cervini A, Shea J, Gilmore J, Lledo L, Dengel K, Marshall A, Wherry EJ, Linette GP, Brennan A, Gonzalez V, Kulikovskaya I, Lacey SF, Plesa G, June CH, Vonderheide RH, Mitchell TC. Cancer Res Commun. 2023 May 9;3(5):821-829. doi: 10.1158/2767-9764.CRC-22-0486. eCollection 2023 May. PMID: 37377890
• Signal recovery in single cell batch integration. Zhang Z, Mathew D, Lim T, Huang S, Wherry EJ, Minn AJ, Ma Z, Zhang NR. bioRxiv. 2023 May 9:2023.05.05.539614. doi: 10.1101/2023.05.05.539614. Preprint. PMID: 37215021 
• High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline. Wang G, Lyudovyk O, Kim JY, Lin YH, Elhanati Y, Mathew D, Wherry EJ, Herati RS, Greenplate AR, Greenbaum B, Vardhana SA, Huang AC. STAR Protoc. 2023 May 8;4(2):102289. doi: 10.1016/j.xpro.2023.102289. Online ahead of print. PMID: 37159385 
• MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity. Gullipalli D, Miwa T, Golla M, Sato S, Angampalli S, Song WC .J Immunol. 2023 May 15;210(10):1543-1551. doi: 10.4049/jimmunol.2200932. PMID: 36988282

April

• Alteration in Cerebral Metabolism in a Rodent Model of Acute Sub-lethal Cyanide Poisoning. Alomaja O, Shofer FS, Greenwood JC, Piel S, Clayman C, Mesaros C, Kao SH, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH. J Med Toxicol. 2023 Apr;19(2):196-204. doi: 10.1007/s13181-022-00928-w. Epub 2023 Feb 9. PMID: 36757579
• Efficient engineering of human and mouse primary cells using peptide-assisted genome editing. Zhang Z, Baxter AE, Ren D, Qin K, Chen Z, Collins SM, Huang H, Komar CA, Bailer PF, Parker JB, Blobel GA, Kohli RM, Wherry EJ, Berger SL, Shi J. Nat Biotechnol. 2023 Apr 24. doi: 10.1038/s41587-023-01756-1. Online ahead of print. PMID: 37095348
• In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40. Wu JE, Manne S, Ngiow SF, Baxter AE, Huang H, Freilich E, Clark ML, Lee JH, Chen Z, Khan O, Staupe RP, Huang YJ, Shi J, Giles JR, Wherry EJ. bioRxiv. 2023 Apr 17:2023.04.17.537229. doi: 10.1101/2023.04.17.537229. Preprint. PMID: 37131713
• Human T follicular helper clones seed the germinal center-resident regulatory pool. Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N. Sci Immunol. 2023 Apr 14;8(82):eade8162. doi: 10.1126/sciimmunol.ade8162. Epub 2023 Apr 7. PMID: 37027481
• Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation. Arp CJ, Reynders M, Sreekanth V, Kokkonda P, Pagano M, Choudhary A, Trauner D. bioRxiv. 2023 Apr 9:2023.04.09.536172. doi: 10.1101/2023.04.09.536172. Preprint. PMID: 37066279

March

• Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput. Eberwine J, Kim J, Anafi RC, Brem S, Bucan M, Fisher SA, Grady MS, Herr AE, Issadore D, Jeong H, Kim H, Lee D, Rubakhin S, Sul JY, Sweedler JV, Wolf JA, Zaret KS, Zou J. Nat Methods. 2023 Mar;20(3):331-335. doi: 10.1038/s41592-023-01788-0. PMID: 36899160 
• Nonsteroidal anti-inflammatory drugs as a targeted therapy for bone marrow failure in Ghosal hematodiaphyseal dysplasia. Brown TJ, Barrett N, Meng H, Ricciotti E, McDonnell C, Dancis A, Qualtieri J, FitzGerald GA, Cotter M, Babushok DV. Blood. 2023 Mar 30;141(13):1553-1559. doi: 10.1182/blood.2022018667. PMID: 36574346
• Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men. Garcia J, Krieger KD, Loitz C, Perez LM, Richards ZA, Helou Y, Kregel S, Celada S, Mesaros CA, Bosland M, Gann PH, Willnow TE, Vander Griend D, Kittles R, Prins GS, Penning T, Nonn L. Cancer Res Commun. 2023 Mar 3;3(3):371-382. doi: 10.1158/2767-9764.CRC-22-0362. eCollection 2023 Mar. PMID: 36875158

Feb

• Post-Translational Chemical Modifications of Amyloid-β Peptides by 4-Hydroxy-2-Nonenal. Kikuchi H, Takahashi M, Komatsu H, Axelsen PH. J Alzheimers Dis. 2023 Feb 7. doi: 10.3233/JAD-220940. Online ahead of print. PMID: 36776059
• Alteration in Cerebral Metabolism in a Rodent Model of Acute Sub-lethal Cyanide Poisoning. Alomaja O, Shofer FS, Greenwood JC, Piel S, Clayman C, Mesaros C, Kao SH, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH. J Med Toxicol. 2023 Feb 9. doi: 10.1007/s13181-022-00928-w. Online ahead of print. PMID: 36757579
• Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures. Nasr Z, Schoeps VA, Ziaei A, Virupakshaiah A, Adams C, Casper TC, Waltz M, Rose J, Rodriguez M, Tillema JM, Chitnis T, Graves JS, Benson L, Rensel M, Krupp L, Waldman AT, Weinstock-Guttman B, Lotze T, Greenberg B, Aaen G, Mar S, Schreiner T, Hart J, Simpson-Yap S, Mesaros C, Barcellos LF, Waubant E. J Neurol Neurosurg Psychiatry. 2023 Feb 1:jnnp-2022-330713. doi: 10.1136/jnnp-2022-330713. Online ahead of print. PMID: 36725329
• Neutrophil-activating therapy for the treatment of cancer. Linde IL, Prestwood TR, Qiu J, Pilarowski G, Linde MH, Zhang X, Shen L, Reticker-Flynn NE, Chiu DK, Sheu LY, Van Deursen S, Tolentino LL, Song WC, Engleman EG. Cancer Cell. 2023 Feb 13;41(2):356-372.e10. doi: 10.1016/j.ccell.2023.01.002. Epub 2023 Jan 26. PMID: 36706760
• The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR ⁺CD8 ⁺ effector state and its deletion improves checkpoint blockade. McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. bioRxiv. 2023 Feb 16:2023.02.16.528833. doi: 10.1101/2023.02.16.528833. Preprint. PMID: 36824931 

Jan

• PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Chen S, Paul MR, Sterner CJ, Belka GK, Wang D, Xu P, Sreekumar A, Pan TC, Pant DK, Makhlin I, DeMichele A, Mesaros C, Chodosh LA. Breast Cancer Res. 2023 Jan 3;25(1):1. doi: 10.1186/s13058-022-01559-3. PMID: 36597146 
• Correction to: Preliminary Research: Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning. Lewis A, Forti RM, Alomaja O, Mesaros C, Piel S, Greenwood JC, Talebi FM, Mavroudis CD, Kelly M, Kao SH, Shofer FS, Ehinger JK, Kilbaugh TJ, Baker WB, Jang DH. J Med Toxicol. 2023 Jan;19(1):53. doi: 10.1007/s13181-022-00913-3. PMID: 36508082 
• Modulation of TRPV2 by endogenous and exogenous ligands: A computational study. Feng S, Pumroy RA, Protopopova AD, Moiseenkova-Bell VY, Im W. Protein Sci. 2023 Jan;32(1):e4490. doi: 10.1002/pro.4490. PMID: 36327382
• Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases. Detlefsen AJ, Paulukinas RD, Penning TM. Int J Mol Sci. 2023 Jan 18;24(3):1873. doi: 10.3390/ijms24031873. PMID: 36768194 
• Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells. Su AL, Penning TM. Chem Res Toxicol. 2023 Jan 24. doi: 10.1021/acs.chemrestox.2c00337. Online ahead of print. PMID: 36693016
• Chimeric Antigen Receptor T-Cell Therapy: Current Perspective on T Cell-Intrinsic, T Cell-Extrinsic, and Therapeutic Limitations. Brookens SK, Posey AD Jr. Cancer J. 2023 Jan-Feb 01;29(1):28-33. doi: 10.1097/PPO.0000000000000636. PMID: 36693155 
• Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease. Ahn K, Penn RB, Rattan S, Panettieri RA Jr, Voight BF, An SS. Am J Respir Crit Care Med. 2023 Jan 15;207(2):130-137. doi: 10.1164/rccm.202205-0951OC. PMID: 36214830
• Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction. Qiu J, Xu B, Ye D, Ren D, Wang S, Benci JL, Xu Y, Ishwaran H, Beltra JC, Wherry EJ, Shi J, Minn AJ. Nat Cancer. 2023 Jan;4(1):43-61. doi: 10.1038/s43018-022-00490-y. Epub 2023 Jan 16. PMID: 36646856
• An extended SARS-CoV-2 mRNA vaccine prime-boost interval enhances B cell immunity with limited impact on T cells. Nicolas A, Sannier G, Dubé M, Nayrac M, Tauzin A, Painter MM, Goel RR, Laporte M, Gendron-Lepage G, Medjahed H, Williams JC, Brassard N, Niessl J, Gokool L, Morrisseau C, Arlotto P, Tremblay C, Martel-Laferrière V, Finzi A, Greenplate AR, Wherry EJ, Kaufmann DE. iScience. 2023 Jan 20;26(1):105904. doi: 10.1016/j.isci.2022.105904. Epub 2022 Dec 29. PMID: 36594081 
• An extended SARS-CoV-2 mRNA vaccine prime-boost interval enhances B cell immunity with limited impact on T cells. Nicolas A, Sannier G, Dubé M, Nayrac M, Tauzin A, Painter MM, Goel RR, Laporte M, Gendron-Lepage G, Medjahed H, Williams JC, Brassard N, Niessl J, Gokool L, Morrisseau C, Arlotto P, Tremblay C, Martel-Laferrière V, Finzi A, Greenplate AR, Wherry EJ, Kaufmann DE. iScience. 2023 Jan 20;26(1):105904. doi: 10.1016/j.isci.2022.105904. Epub 2022 Dec 29. PMID: 36594081 
• Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction. Qiu J, Xu B, Ye D, Ren D, Wang S, Benci JL, Xu Y, Ishwaran H, Beltra JC, Wherry EJ, Shi J, Minn AJ. Nat Cancer. 2023 Jan;4(1):43-61. doi: 10.1038/s43018-022-00490-y. Epub 2023 Jan 16. PMID: 36646856