Archived Publications
December 2022
- A novel Oprm1-Cre mouse maintains endogenous expression, function and enables detailed molecular characterization of μ-opioid receptor cells. Mengaziol J, Dunn AD, Salimando G, Wooldridge L, Crues-Muncunill J, Eacret D, Chen C, Bland K, Liu-Chen LY, Ehrlich ME, Corder G, Blendy JA. PLoS One. 2022 Dec 19;17(12):e0270317. doi: 10.1371/journal.pone.0270317. eCollection 2022. PMID: 36534642
- Cell-type specific profiling of histone post-translational modifications in the adult mouse striatum. Carpenter MD, Fischer DK, Zhang S, Bond AM, Czarnecki KS, Woolf MT, Song H, Heller EA. Nat Commun. 2022 Dec 13;13(1):7720. doi: 10.1038/s41467-022-35384-1. PMID: 36513652
- Convergent actions of stress and stimulants via epigenetic regulation of neural circuitry. Murphy MD, Heller EA. Trends Neurosci. 2022 Dec;45(12):955-967. doi: 10.1016/j.tins.2022.10.001. Epub 2022 Oct 22. PMID: 36280459
- Germline intergenic duplications at Xq26.1 underlie Bazex-Dupré-Christol basal cell carcinoma susceptibility syndrome. Liu Y, Banka S, Huang Y, Hardman-Smart J, Pye D, Torrelo A, Beaman GM, Kazanietz MG, Baker MJ, Ferrazzano C, Shi C, Orozco G, Eyre S, van Geel M, Bygum A, Fischer J, Miedzybrodzka Z, Abuzahra F, Rübben A, Cuvertino S, Ellingford JM, Smith MJ, Evans DG, Weppner-Parren LJMT, van Steensel MAM, Chaudhary IH, Mangham DC, Lear JT, Paus R, Frank J, Newman WG, Zhang X. Br J Dermatol. 2022 Dec;187(6):948-961. doi: 10.1111/bjd.21842. Epub 2022 Sep 12. PMID: 35986704
- Role of Human Aldo-Keto Reductases in the Nitroreduction of 1-Nitropyrene and 1,8-Dinitropyrene. Su AL, Mesaros CA, Krzeminski J, El-Bayoumy K, Penning TM. Chem Res Toxicol. 2022 Dec 19;35(12):2296-2309. doi: 10.1021/acs.chemrestox.2c00271. Epub 2022 Nov 18. PMID: 36399404
- An End Point-Specific Framework for Read-Across Analog Selection for Human Health Effects. Moustakas H, Date MS, Kumar M, Schultz TW, Liebler DC, Penning TM, Salvito DT, Api AM. Chem Res Toxicol. 2022 Dec 19;35(12):2324-2334. doi: 10.1021/acs.chemrestox.2c00286. Epub 2022 Dec 2. PMID: 36458907
- Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr. Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7. doi: 10.1016/j.ccell.2022.11.006. PMID: 36513049
- Non-steroidal anti-inflammatory drugs as a targeted therapy for bone marrow failure in Ghosal Hematodiaphyseal Dysplasia.
- A decline of protective apolipoprotein J and complement factor H concomitant with increase in C5a 3 months after cardiac surgery-Evidence of long-term complement perturbations. Laudanski K, Liu D, Gullipalli D, Song WC, Okeke T, Szeto WY. Front Cardiovasc Med. 2022 Dec 20;9:983617. doi: 10.3389/fcvm.2022.983617. eCollection 2022. PMID: 36606279
- Mapping the T cell epitopes of the M-type transmembrane phospholipase A2 receptor in primary membranous nephropathy. Zhang XD, Lin CX, Cui Z, Gu QH, Yan BJ, Liu L, Song WC, Shi Y, Debiec H, Ronco P, Zhao MH. Kidney Int. 2022 Dec 20:S0085-2538(22)01039-0. doi: 10.1016/j.kint.2022.11.021. Online ahead of print. PMID: 36549363
- Genomics and phenomics of body mass index reveals a complex disease network. Huang J, Huffman JE, Huang Y, Do Valle Í, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási AL, Huang RDL, Hui Q, Nguyen XT, Ho YL, Djousse L, Lynch JA, Vujkovic M, Tcheandjieu C, Tang H, Damrauer SM, Reaven PD, Miller D, Phillips LS, Ng MCY, Graff M, Haiman CA, Loos RJF, North KE, Yengo L, Smith GD, Saleheen D, Gaziano JM, Rader DJ, Tsao PS, Cho K, Chang KM, Wilson PWF; VA Million Veteran Program; Sun YV, O'Donnell CJ. Nat Commun.2022 Dec 29;13(1):7973. doi: 10.1038/s41467-022-35553-2. PMID: 36581621
- Validating a Proteomic Signature of Severe COVID-19. Cosgriff CV, Miano TA, Mathew D, Huang AC, Giannini HM, Kuri-Cervantes L, Pampena MB, Ittner CAG, Weisman AR, Agyekum RS, Dunn TG, Oniyide O, Turner AP, D'Andrea K, Adamski S, Greenplate AR, Anderson BJ, Harhay MO, Jones TK, Reilly JP, Mangalmurti NS, Shashaty MGS, Betts MR, Wherry EJ, Meyer NJ. Crit Care Explor. 2022 Dec 1;4(12):e0800. doi: 10.1097/CCE.0000000000000800. eCollection 2022 Dec. PMID: 36479446
- Author Correction: Decade-long leukaemia remissions with persistence of CD4+CAR T cells. Melenhorst JJ, Chen GM, Wang M, Porter DL, Chen C, Collins MA, Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, Gill SI, Loren AW, Tian L, Kulikovskaya I, Gupta M, Ambrose DE, Davis MM, Fraietta JA, Brogdon JL, Young RM, Chew A, Levine BL, Siegel DL, Alanio C, Wherry EJ, Bushman FD, Lacey SF, Tan K, June CH. Nature. 2022 Dec;612(7941):E22. doi: 10.1038/s41586-022-05376-8. PMID: 36477542
November 2022
- Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z. Cell Metab. 2022 Nov 1;34(11):1749-1764.e7. doi: 10.1016/j.cmet.2022.09.008. Epub 2022 Oct 11. PMID: 36223763
- Ruxolitinib and exemestane for estrogen receptor positive, aromatase inhibitor resistant advanced breast cancer. Makhlin I, McAndrew NP, Wileyto EP, Clark AS, Holmes R, Bottalico LN, Mesaros C, Blair IA, Jeschke GR, Fox KR, Domchek SM, Matro JM, Bradbury AR, Feldman MD, Hexner EO, Bromberg JF, DeMichele A. NPJ Breast Cancer. 2022 Nov 11;8(1):122. doi: 10.1038/s41523-022-00487-x. PMID: 36369506
- A common SNP in Chrna5 enhances morphine reward in female mice. Brynildsen JK, Yang K, Lemchi C, Dani JA, De Biasi M, Blendy JA. Neuropharmacology. 2022 Nov 1;218:109218. doi: 10.1016/j.neuropharm.2022.109218. Epub 2022 Aug 13. PMID: 35973602
- BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion. Jung IY, Narayan V, McDonald S, Rech AJ, Bartoszek R, Hong G, Davis MM, Xu J, Boesteanu AC, Barber-Rotenberg JS, Plesa G, Lacey SF, Jadlowsky JK, Siegel DL, Hammill DM, Cho-Park PF, Berger SL, Haas NB, Fraietta JA. Sci Transl Med. 2022 Nov 9;14(670):eabn7336. doi: 10.1126/scitranslmed.abn7336. Epub 2022 Nov 9. PMID: 36350986
- Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells. Sakata Y, Cheng K, Mayama M, Seita Y, Detlefsen AJ, Mesaros CA, Penning TM, Shishikura K, Yang W, Auchus RJ, Strauss JF 3rd, Sasaki K. Dev Cell. 2022 Nov 21;57(22):2566-2583.e8. doi: 10.1016/j.devcel.2022.10.010. PMID: 36413950
- Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure. Levin MG, Tsao NL, Singhal P, Liu C, Vy HMT, Paranjpe I, Backman JD, Bellomo TR, Bone WP, Biddinger KJ, Hui Q, Dikilitas O, Satterfield BA, Yang Y, Morley MP, Bradford Y, Burke M, Reza N, Charest B; Regeneron Genetics Center; Judy RL, Puckelwartz MJ, Hakonarson H, Khan A, Kottyan LC, Kullo I, Luo Y, McNally EM, Rasmussen-Torvik LJ, Day SM, Do R, Phillips LS, Ellinor PT, Nadkarni GN, Ritchie MD, Arany Z, Cappola TP, Margulies KB, Aragam KG, Haggerty CM, Joseph J, Sun YV, Voight BF, Damrauer SM. Nat Commun. 2022 Nov 14;13(1):6914. doi: 10.1038/s41467-022-34216-6. PMID: 36376295
- Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer. Lu Z, Chen J, Yu P, Atherton MJ, Gui J, Tomar VS, Middleton JD, Sullivan NT, Singhal S, George SS, Woolfork AG, Weljie AM, Hai T, Eruslanov EB, Fuchs SY. Nat Commun. 2022 Nov 4;13(1):6623. doi: 10.1038/s41467-022-34428-w. PMID: 36333297
- Divergent clonal differentiation trajectories of T cell exhaustion. Daniel B, Yost KE, Hsiung S, Sandor K, Xia Y, Qi Y, Hiam-Galvez KJ, Black M, J Raposo C, Shi Q, Meier SL, Belk JA, Giles JR, Wherry EJ, Chang HY, Egawa T, Satpathy AT. Nat Immunol. 2022 Nov;23(11):1614-1627. doi: 10.1038/s41590-022-01337-5. Epub 2022 Oct 26. PMID: 36289450
- Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics. Giles JR, Ngiow SF, Manne S, Baxter AE, Khan O, Wang P, Staupe R, Abdel-Hakeem MS, Huang H, Mathew D, Painter MM, Wu JE, Huang YJ, Goel RR, Yan PK, Karakousis GC, Xu X, Mitchell TC, Huang AC, Wherry EJ. Nat Immunol. 2022 Nov;23(11):1600-1613. doi: 10.1038/s41590-022-01338-4. Epub 2022 Oct 21. PMID: 36271148
October 2022
- Cell contractility and Focal Adhesion Kinase control circumferential arterial stiffness. Roberts E, Xu T, Assoian R. Vasc Biol. 2022 Oct 1;4(1):28-39. doi: 10.1530/VB-22-0013. Online ahead of print. PMID: 36222505
- Characterization and Quantification of Oxidized High Mobility Group Box 1 Proteoforms Secreted from Hepatocytes by Toxic Levels of Acetaminophen. Pirnie R, Gillespie KP, Weng L, Mesaros C, Blair IA. Chem Res Toxicol. 2022 Oct 17;35(10):1893-1902. doi: 10.1021/acs.chemrestox.2c00161. Epub 2022 Aug 3. PMID: 35922039
- Nonredundant Rac-GEF control of actin cytoskeleton reorganization. Kazanietz MG, Cooke M, Garcia-Mata R. Trends Cell Biol. 2022 Oct;32(10):815-818. doi: 10.1016/j.tcb.2022.06.003. Epub 2022 Jun 23. PMID: 35753960
- Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach. Ding Z, Ritchie MD, Voight BF, Hwang WT. BMC Bioinformatics. 2022 Oct 13;23(1):420. doi: 10.1186/s12859-022-04977-4. PMID: 36229773
- PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma. Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. JCI Insight. 2022 Oct 24;7(20):e165688. doi: 10.1172/jci.insight.165688. PMID: 36278493
- SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations. Anderson EM, Li SH, Awofolaju M, Eilola T, Goodwin E, Bolton MJ, Gouma S, Manzoni TB, Hicks P, Goel RR, Painter MM, Apostolidis SA, Mathew D, Dunbar D, Fiore D, Brock A, Weaver J, Millar JS, DerOhannessian S; UPenn COVID Processing Unit; Greenplate AR, Frank I, Rader DJ, Wherry EJ, Bates P, Hensley SE. Cell Rep. 2022 Oct 18;41(3):111496. doi: 10.1016/j.celrep.2022.111496. PMID: 36261003
- A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two doses. Tauzin A, Gong SY, Chatterjee D, Ding S, Painter MM, Goel RR, Beaudoin-Bussières G, Marchitto L, Boutin M, Laumaea A, Okeny J, Gendron-Lepage G, Bourassa C, Medjahed H, Goyette G, Williams JC, Bo Y, Gokool L, Morrisseau C, Arlotto P, Bazin R, Fafard J, Tremblay C, Kaufmann DE, De Serres G, Richard J, Côté M, Duerr R, Martel-Laferrière V, Greenplate AR, Wherry EJ, Finzi A. Cell Rep. 2022 Oct 25;41(4):111554. doi: 10.1016/j.celrep.2022.111554. Epub 2022 Oct 5. PMID: 36244343
- Correction for Merenstein et al., "Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome". Merenstein C, Liang G, Whiteside SA, Cobián-Güemes AG, Merlino MS, Taylor LJ, Glascock A, Bittinger K, Tanes C, Graham-Wooten J, Khatib LA, Fitzgerald AS, Reddy S, Baxter AE, Giles JR, Oldridge DA, Meyer NJ, Wherry EJ, McGinniss JE, Bushman FD, Collman RG. mBio. 2022 Oct 26;13(5):e0229322. doi: 10.1128/mbio.02293-22. Epub 2022 Aug 31. PMID: 36043873
September 2022
- Cocaine regulation of Nr4a1 chromatin bivalency and mRNA in male and female mice. Fischer DK, Krick KS, Han C, Woolf MT, Heller EA. Sci Rep. 2022 Sep 21;12(1):15735. doi: 10.1038/s41598-022-19908-9. PMID: 36130958
- Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1. Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh SJ, Reiterer V, Parizadeh A, Felder E, Kahlhofer JC, Teis D, Kazanietz MG, Geley S, Eriksson L, Roca-Cusachs P, Farhan H. EMBO J. 2022 Sep 15;41(18):e110596. doi: 10.15252/embj.2022110596. Epub 2022 Aug 8. PMID: 35938214
- What structures did, and did not, reveal about the function of the epithelial Ca2+channels TRPV5 and TRPV6. Rohacs T, Fluck EC, De Jesús-Pérez JJ, Moiseenkova-Bell VY. Cell Calcium. 2022 Sep;106:102620. doi: 10.1016/j.ceca.2022.102620. Epub 2022 Jul 3. PMID: 35834842
- Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study. Greenwood JC, Talebi FM, Jang DH, Spelde AE, Tonna JE, Gutsche JT, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JGT, Bakker J, Brenner JS, Muzykantov VR, Abella BS. Sci Rep. 2022 Sep 10;12(1):15257. doi: 10.1038/s41598-022-19741-0. PMID: 36088474
- Quantification of Plasma 8-Isoprostane by High-Performance Liquid Chromatography with Tandem Mass Spectrometry in a Case-Control Study of Lung Cancer. Ma L, Sun D, Xiu G, Lazarus P, Vachani A, Penning TM, Whitehead AS, Muscat JE. Int J Environ Res Public Health. 2022 Sep 30;19(19):12488. doi: 10.3390/ijerph191912488. PMID: 36231826
- ColocQuiaL: a QTL-GWAS colocalization pipeline. Chen BY, Bone WP, Lorenz K, Levin M, Ritchie MD, Voight BF. Bioinformatics. 2022 Sep 15;38(18):4409-4411. doi: 10.1093/bioinformatics/btac512. PMID: 35894642
- Building effective collaborations for the study of COVID-19 across the severity spectrum. Agyekum RS, Abramoff BA, Wherry EJ, Meyer NJ. Nat Immunol. 2022 Sep;23(9):1287-1290. doi: 10.1038/s41590-022-01283-2. PMID: 35999396
August 2022
- Characterization and Quantification of Oxidized High Mobility Group Box 1 Proteoforms Secreted from Hepatocytes by Toxic Levels of Acetaminophen. Pirnie R, Gillespie KP, Weng L, Mesaros C, Blair IA. Chem Res Toxicol. 2022 Aug 3. doi: 10.1021/acs.chemrestox.2c00161. Online ahead of print. PMID: 35922039
- A common SNP in Chrna5 enhances morphine reward in female mice. Brynildsen JK, Yang K, Lemchi C, Dani JA, De Biasi M, Blendy JA. Neuropharmacology. 2022 Aug 13:109218. doi: 10.1016/j.neuropharm.2022.109218. Online ahead of print. PMID: 35973602
- Germline intergenic duplications at Xq26.1 underlie Bazex-Dupré-Christol basal cell carcinoma susceptibility syndrome. Liu Y, Banka S, Huang Y, Hardman-Smart J, Pye D, Torrelo A, Beaman GM, Kazanietz MG, Baker MJ, Ferrazzano C, Shi C, Orozco G, Eyre S, van Geel M, Bygum A, Fischer J, Miedzybrodzka Z, Abuzahra F, Rübben A, Cuvertino S, Ellingford JM, Smith MJ, Evans DG, Weppner-Parren LJMT, van Steensel MAM, Chaudhary IH, Mangham DC, Lear JT, Paus R, Frank J, Newman WG, Zhang X. Br J Dermatol. 2022 Aug 20. doi: 10.1111/bjd.21842. Online ahead of print. PMID: 35986704
- Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1. Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh SJ, Reiterer V, Parizadeh A, Felder E, Kahlhofer JC, Teis D, Kazanietz MG, Geley S, Eriksson L, Roca-Cusachs P, Farhan H. EMBO J. 2022 Aug 8:e110596. doi: 10.15252/embj.2022110596. Online ahead of print. PMID: 35938214
- Automating Predictive Toxicology Using ComptoxAI. Romano JD, Hao Y, Moore JH, Penning TM. Chem Res Toxicol. 2022 Aug 15;35(8):1370-1382. doi: 10.1021/acs.chemrestox.2c00074. Epub 2022 Jul 12. PMID: 35819939
- Air pollution and lung cancer survival in Pennsylvania. McKeon TP, Anil Vachani, Penning TM, Hwang WT. Lung Cancer. 2022 Aug;170:65-73. doi: 10.1016/j.lungcan.2022.06.004. Epub 2022 Jun 10. PMID: 35716633
- Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep. Jha PK, Valekunja UK, Ray S, Nollet M, Reddy AB. Commun Biol. 2022 Aug 19;5(1):846. doi: 10.1038/s42003-022-03800-3. PMID: 35986171
- A disturbed balance between blood complement protective factors (FH, ApoE) and common pathway effectors (C5a, TCC) in acute COVID-19 and during convalesce. Laudanski K, Okeke T, Siddiq K, Hajj J, Restrepo M, Gullipalli D, Song WC. Sci Rep. 2022 Aug 11;12(1):13658. doi: 10.1038/s41598-022-17011-7. PMID: 35953544 PMCID: PMC9366819
July 2022
- Free Radical Chain Reactions and Polyunsaturated Fatty Acids in Brain Lipids. Ng SCW, Furman R, Axelsen PH, Shchepinov MS.
ACS Omega. 2022 Jul 14;7(29):25337-25345. doi: 10.1021/acsomega.2c02285. eCollection 2022 Jul 26. PMID: 35910174 PMCID: PMC9330197 - The Kinetics and (Dys)kinetics of Cancer Chronotherapy. Field JM, Sehgal A. Cancer Res. 2022 Jul 5;82(13):2357-2360. doi: 10.1158/0008-5472.CAN-21-3799. PMID: 35709495 PMCID: PMC9256782
- Targeted In Vivo Loading of Red Blood Cells Markedly Prolongs Nanocarrier Circulation. Glassman PM, Villa CH, Marcos-Contreras OA, Hood ED, Walsh LR, Greineder CF, Myerson JW, Shuvaeva T, Puentes L, Brenner JS, Siegel DL, Muzykantov VR. Bioconjug Chem. 2022 Jul 20;33(7):1286-1294. doi: 10.1021/acs.bioconjchem.2c00196. Epub 2022 Jun 16. PMID: 35710322
- Skin fibroblast metabolomic profiling reveals that lipid dysfunction predicts the severity of Friedreich's ataxia. Wang D, Ho ES, Cotticelli MG, Xu P, Napierala JS, Hauser LA, Napierala M, Himes BE, Wilson RB, Lynch DR, Mesaros C. J Lipid Res. 2022 Jul 16;63(9):100255. doi: 10.1016/j.jlr.2022.100255. Online ahead of print. PMID: 35850241
- Conversion of Classical and 11-Oxygenated Androgens by Insulin-Induced AKR1C3 in a Model of Human PCOS Adipocytes. Paulukinas RD, Mesaros CA, Penning TM. Endocrinology. 2022 Jul 1;163(7):bqac068. doi: 10.1210/endocr/bqac068. PMID: 35560164
- Preliminary Research: Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning. Lewis AT, Forti RM, Alomaja O, Mesaros C, Piel S, Greenwood JC, Talebi FM, Mavroudis CD, Kelly M, Kao SH, Shofer FS, Ehinger JK, Kilbaugh TJ, Baker WB, Jang DH. J Med Toxicol. 2022 Jul;18(3):214-222. doi: 10.1007/s13181-022-00892-5. Epub 2022 Apr 28. PMID: 35482181 PMCID: PMC9198167
- What structures did, and did not, reveal about the function of the epithelial Ca2+ channels TRPV5 and TRPV6. Rohacs T, Fluck EC, De Jesús-Pérez JJ, Moiseenkova-Bell VY. Cell Calcium. 2022 Jul 3;106:102620. doi: 10.1016/j.ceca.2022.102620. Online ahead of print. PMID: 35834842
- Red Blood Cell Anchoring Enables Targeted Transduction and Re-Administration of AAV-Mediated Gene Therapy. Zhao Z, Kim J, Suja VC, Kapate N, Gao Y, Guo J, Muzykantov VR, Mitragotri S. Adv Sci (Weinh). 2022 Jul 3:e2201293. doi: 10.1002/advs.202201293. Online ahead of print. PMID: 35780495
- Peripheral blood leukocyte mitochondrial DNA content and risk of lung cancer. Kennedy GT, Mitra N, Penning TM, Whitehead AS, Vachani A. Transl Lung Cancer Res. 2022 Jul;11(7):1268-1278. doi: 10.21037/tlcr-21-979. PMID: 35958326 PMCID: PMC9359958
- Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase). Detlefsen AJ, Wangtrakuldee P, Penning TM. J Steroid Biochem Mol Biol. 2022 Jul;221:106121. doi: 10.1016/j.jsbmb.2022.106121. Epub 2022 Apr 28. PMID: 35489629
- The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG 3rd, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD Jr, Mullins RD, Eyquem J, Wells JA, Wiita AP. Nat Commun. 2022 Jul 15;13(1):4121. doi: 10.1038/s41467-022-31810-6. PMID: 35840578
- ColocQuiaL: A QTL-GWAS colocalization pipeline. Chen BY, Bone WP, Lorenz K, Levin M, Ritchie MD, Voight BF. Bioinformatics. 2022 Jul 27:btac512. doi: 10.1093/bioinformatics/btac512. Online ahead of print. PMID: 35894642
- Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease. Liu H, Doke T, Guo D, Sheng X, Ma Z, Park J, Vy HMT, Nadkarni GN, Abedini A, Miao Z, Palmer M, Voight BF, Li H, Brown CD, Ritchie MD, Shu Y, Susztak K. Nat Genet. 2022 Jul;54(7):950-962. doi: 10.1038/s41588-022-01097-w. Epub 2022 Jun 16. PMID: 35710981
June 2022
- Ultrasensitive Single Extracellular Vesicle Detection Using High Throughput Droplet Digital Enzyme-Linked Immunosorbent Assay. Yang Z, Atiyas Y, Shen H, Siedlik MJ, Wu J, Beard K, Fonar G, Dolle JP, Smith DH, Eberwine JH, Meaney DF, Issadore DA. Nano Lett. 2022 Jun 8;22(11):4315-4324. doi: 10.1021/acs.nanolett.2c00274. Epub 2022 May 19. PMID: 35588529
- Nonredundant Rac-GEF control of actin cytoskeleton reorganization. Kazanietz MG, Cooke M, Garcia-Mata R. Trends Cell Biol. 2022 Jun 23:S0962-8924(22)00142-8. doi: 10.1016/j.tcb.2022.06.003. Online ahead of print. PMID: 35753960
- Quantification of ruffle area and dynamics in live or fixed lung adenocarcinoma cells. Kreider-Letterman G, Cooke M, Goicoechea SM, Kazanietz MG, Garcia-Mata R. STAR Protoc. 2022 Jun 4;3(2):101437. doi: 10.1016/j.xpro.2022.101437. eCollection 2022 Jun 17. PMID: 35677607
- Astrocyte ethanol exposure reveals persistent and defined calcium response subtypes and associated gene signatures. Kim HB, Lu Y, Oh SC, Morris J, Miyashiro K, Kim J, Eberwine J, Sul JY. J Biol Chem. 2022 Jun 16;298(8):102147. doi: 10.1016/j.jbc.2022.102147. Online ahead of print. PMID: 35716779 PMCID: PMC9293641
- TSABL: Trait Specific Annotation Based Locus predictor. Lorenz K, Thom CS, Adurty S, Voight BF. BMC Genomics. 2022 Jun 15;23(1):444. doi: 10.1186/s12864-022-08654-x. PMID: 35705896
- Characterization of the genome and silk-gland transcriptomes of Darwin's bark spider (Caerostris darwini). Babb PL, Gregorič M, Lahens NF, Nicholson DN, Hayashi CY, Higgins L, Kuntner M, Agnarsson I, Voight BF. PLoS One. 2022 Jun 6;17(6):e0268660. doi: 10.1371/journal.pone.0268660. eCollection 2022. PMID: 35666730 PMCID: PMC9170102
- A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Townsend Creasy K, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program, Rader DJ, Voight BF, Chang KM. Nat Genet. 2022 Jun;54(6):761-771. doi: 10.1038/s41588-022-01078-z. Epub 2022 Jun 2. PMID: 35654975
- A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program. Raghavan S, Huang J, Tcheandjieu C, Huffman JE, Litkowski E, Liu C, Ho YA, Hunter-Zinck H, Zhao H, Marouli E, North KE; VA Million Veteran Program, Lange E, Lange LA, Voight BF, Gaziano JM, Pyarajan S, Hauser ER, Tsao PS, Wilson PWF, Chang KM, Cho K, O'Donnell CJ, Sun YV, Assimes TL. PLoS Genet. 2022 Jun 2;18(6):e1010193. doi: 10.1371/journal.pgen.1010193. eCollection 2022 Jun. PMID: 35653334
- Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations. Temprano-Sagrera G, Sitlani CM, Bone WP, Martin-Bornez M, Voight BF, Morrison AC, Damrauer SM, de Vries PS, Smith NL, Sabater-Lleal M. J Thromb Haemost. 2022 Jun;20(6):1331-1349. doi: 10.1111/jth.15698. Epub 2022 Mar 29. PMID: 35285134
May 2022
- Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.
Sela Y, Li J, Maheswaran S, Norgard R, Yuan S, Hubbi M, Doepner M, Xu JP, Ho ES, Mesaros C, Sheehan C, Croley G, Muir A, Blair IA, Shalem O, Dang CV, Stanger BZ. Cancer Res. 2022 May 16;82(10):1890-1908. doi: 10.1158/0008-5472.CAN-22-0431. PMID: 35315913 PMCID: PMC9117449 - Targeting vascular inflammation through emerging methods and drug carriers. Nong J, Glassman PM, Muzykantov VR. Adv Drug Deliv Rev. 2022 May;184:114180. doi: 10.1016/j.addr.2022.114180. Epub 2022 Mar 7. PMID: 35271986
- Identification of spatio-temporal clusters of lung cancer cases in Pennsylvania, USA: 2010-2017. Camiña N, McWilliams TL, McKeon TP, Penning TM, Hwang WT. BMC Cancer. 2022 May 17;22(1):555. doi: 10.1186/s12885-022-09652-8. PMID: 35581566 PMCID: PMC9112439
- Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer. Camiña N, Penning TM. Br J Cancer. 2022 May;126(9):1244-1252. doi: 10.1038/s41416-021-01642-0. Epub 2021 Nov 29. PMID: 34845361
April 2022
- Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload. Liu Y, Bell BA, Song Y, Zhang K, Anderson B, Axelsen PH, Bohannan W, Agbaga MP, Park HG, James G, Brenna JT, Schmidt K, Dunaief JL, Shchepinov MS. Aging Cell. 2022 Apr;21(4):e13579. doi: 10.1111/acel.13579. Epub 2022 Mar 8. PMID: 35257475 PMCID: PMC9009113
- Simultaneous Quantification of Mitochondrial Mature Frataxin and Extra-Mitochondrial Frataxin Isoform E in Friedreich's Ataxia Blood. Wang Q, Laboureur L, Weng L, Eskenazi NM, Hauser LA, Mesaros C, Lynch DR, Blair IA. Front Neurosci. 2022 Apr 28;16:874768. doi: 10.3389/fnins.2022.874768. eCollection 2022. PMID: 35573317 PMCID: PMC9098139
- Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity. Cooke M, Kazanietz MG. Sci Signal. 2022 Apr 12;15(729):eabo0264. doi: 10.1126/scisignal.abo0264. Epub 2022 Apr 12. PMID: 35412850
- Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE). Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR. J Control Release. 2022 Apr;344:50-61. doi: 10.1016/j.jconrel.2021.12.027. Epub 2021 Dec 23. PMID: 34953981 PMCID: PMC8695324
- Structural insights into TRPV2 activation by small molecules. Pumroy RA, Protopopova AD, Fricke TC, Lange IU, Haug FM, Nguyen PT, Gallo PN, Sousa BB, Bernardes GJL, Yarov-Yarovoy V, Leffler A, Moiseenkova-Bell VY. Nat Commun. 2022 Apr 28;13(1):2334. doi: 10.1038/s41467-022-30083-3. PMID: 35484159
- Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Fluck EC, Yazici AT, Rohacs T, Moiseenkova-Bell VY. Cell Rep. 2022 Apr 26;39(4):110737. doi: 10.1016/j.celrep.2022.110737. PMID: 35476976 PMCID: PMC9088182
- AKR1D1 knockout mice develop a sex-dependent metabolic phenotype. Gathercole LL, Nikolaou N, Harris SE, Arvaniti A, Poolman TM, Hazlehurst JM, Kratschmar DV, Todorčević M, Moolla A, Dempster N, Pink RC, Saikali MF, Bentley L, Penning TM, Ohlsson C, Cummins CL, Poutanen M, Odermatt A, Cox RD, Tomlinson JW. J Endocrinol. 2022 Apr 13;253(3):97-113. doi: 10.1530/JOE-21-0280. PMID: 35318963
March 2022
- DNA methylation in Friedreich ataxia silences expression of frataxin isoform E. Rodden LN, Gilliam KM, Lam C, Rojsajjakul T, Mesaros C, Dionisi C, Pook M, Pandolfo M, Lynch DR, Blair IA, Bidichandani SI. Sci Rep.2022 Mar 23;12(1):5031. doi: 10.1038/s41598-022-09002-5. PMID: 35322126 PMCID: PMC8943190
- Dual Affinity to RBCs and Target Cells (DART) Enhances Both Organ- and Cell Type-Targeting of Intravascular Nanocarriers. Ferguson LT, Hood ED, Shuvaeva T, Shuvaev VV, Basil MC, Wang Z, Nong J, Ma X, Wu J, Myerson JW, Marcos-Contreras OA, Katzen J, Carl JM, Morrisey EE, Cantu E, Villa CH, Mitragotri S, Muzykantov VR, Brenner JS. ACS Nano. 2022 Mar 22;16(3):4666-4683. doi: 10.1021/acsnano.1c11374. Epub 2022 Mar 10. PMID: 35266686 PMCID: PMC9339245
February 2022
- Chronic Sleep Deprivation Blocks Voluntary Morphine Consumption but Not Conditioned Place Preference in Mice. Eacret D, Lemchi C, Caulfield JI, Cavigelli SA, Veasey SC, Blendy JA. Front Neurosci. 2022 Feb 17;16:836693. doi: 10.3389/fnins.2022.836693. eCollection 2022. PMID: 35250468 PMCID: PMC8892254
- Progerin mislocalizes myocardin-related transcription factor in Hutchinson-Guilford Progeria syndrome. von Kleeck R, Castagnino P, Assoian RK. Vasc Biol. 2022 Feb 15;4(1):1-10. doi: 10.1530/VB-21-0018. eCollection 2022 Feb 1. PMID: 35441125 PMCID: PMC9012937
- Cytomegalovirus latent infection is associated with an increased risk of COVID-19-related hospitalization. Alanio C, Verma A, Mathew D, Gouma S, Liang G, Dunn T, Oldridge DA, Weaver JE, Kuri-Cervantes L, Pampena MB; UPenn COVID Processing Unit, Betts MR, Collman RG, Bushman FD, Meyer NJ, Hensley SE, Rader D, Wherry EJ. J Infect Dis. 2022 Feb 2:jiac020. doi: 10.1093/infdis/jiac020. Online ahead of print. PMID: 35134186
- Decade-long leukaemia remissions with persistence of CD4 + CAR T cells. Melenhorst JJ, Chen GM, Wang M, Porter DL, Chen C, Collins MA, Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, Gill SI, Tian L, Kulikovskaya I, Gupta M, Ambrose DE, Davis MM, Fraietta JA, Brogdon JL, Young RM, Chew A, Levine BL, Siegel DL, Alanio C, Wherry EJ, Bushman FD, Lacey SF, Tan K, June CH. Nature. 2022 Feb 2. doi: 10.1038/s41586-021-04390-6. Online ahead of print. PMID: 35110735
- Consequences of prefrontal tDCS on inhibitory control and reactive aggression. Weidler C, Habel U, Wallheinke P, Wagels L, Hofhansel L, Ling S, Blendy JA, Clemens B. Soc Cogn Affect Neurosci. 2022 Feb 3;17(1):120-130. doi: 10.1093/scan/nsaa158. PMID: 33227131
- Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology. Banka S, Bennington A, Baker MJ, Rijckmans E, Clemente GD, Ansor NM, Sito H, Prasad P, Anyane-Yeboa K, Badalato L, Dimitrov B, Fitzpatrick D, Hurst ACE, Jansen AC, Kelly MA, Krantz I, Rieubland C, Ross M, Rudy NL, Sanz J, Stouffs K, Xu ZL, Malliri A, Kazanietz MG, Millard TH. Brain. 2022 Feb 9:awac049. doi: 10.1093/brain/awac049. Online ahead of print. PMID: 35139179
- Combating Complement's Deleterious Effects on Nanomedicine by Conjugating Complement Regulatory Proteins to Nanoparticles. Wang Z, Hood ED, Nong J, Ding J, Marcos-Contreras OA, Glassman PM, Rubey KM, Zaleski M, Espy CL, Gullipali D, Miwa T, Muzykantov VR, Song WC, Myerson JW, Brenner JS. Adv Mater. 2022 Feb;34(8):e2107070. doi: 10.1002/adma.202107070. Epub 2022 Jan 11. PMID: 34910334 PMCID: PMC9062787
- Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci. Bellomo TR, Bone WP, Chen BY, Gawronski KAB, Zhang D, Park J, Levin M, Tsao N, Klarin D, Lynch J, Assimes TL, Gaziano JM, Wilson PW, Cho K, Vujkovic M, O'Donnell CJ, Chang KM, Tsao PS, Rader DJ, Ritchie MD, Damrauer SM, Voight BF. Front Genet. 2022 Feb 2;12:787545. doi: 10.3389/fgene.2021.787545. eCollection 2021. PMID: 35186008
January 2022
- Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice. Kwon DY, Xu B, Hu P, Zhao YT, Beagan JA, Nofziger JH, Cui Y, Phillips-Cremins JE, Blendy JA, Wu H, Zhou Z. Nat Commun. 2022 Jan 10;13(1):55. doi: 10.1038/s41467-021-27571-3. PMID: 35013139
- The A118G single-nucleotide polymorphism in OPRM1 is a risk factor for asthma severity. Kawakami K, Miyasaka T, Nakamura Y, Metoki H, Miyata S, Sato M, Sora I, Yamauchi K, Kawakami K, Blendy JA, Kawano T, Shimokawa H, Takayanagi M, Ohno I, Takahashi T. Allergol Int. 2022 Jan;71(1):55-65. doi: 10.1016/j.alit.2021.08.006. Epub 2021 Oct 27. PMID: 34688555
- Live Cell Genomics: Cell-Specific Transcriptome Capture in Live Single Cells from Complex Tissues. Lee J, Eberwine J. Methods Mol Biol. 2022;2383:617-626. doi: 10.1007/978-1-0716-1752-6_40. PMID: 34766318
- Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Ahmed T, Nisler CR, Fluck EC 3rd, Walujkar S, Sotomayor M, Moiseenkova-Bell VY. Structure. 2022 Jan 6;30(1):139-155.e5. doi: 10.1016/j.str.2021.08.003. Epub 2021 Aug 27. PMID: 34453887
- Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Myerson JW, Patel PN, Rubey KM, Zamora ME, Zaleski MH, Habibi N, Walsh LR, Lee YW, Luther DC, Ferguson LT, Marcos-Contreras OA, Glassman PM, Mazaleuskaya LL, Johnston I, Hood ED, Shuvaeva T, Wu J, Zhang HY, Gregory JV, Kiseleva RY, Nong J, Grosser T, Greineder CF, Mitragotri S, Worthen GS, Rotello VM, Lahann J, Muzykantov VR, Brenner JS. Nat Nanotechnol. 2022 Jan;17(1):86-97. doi: 10.1038/s41565-021-00997-y. Epub 2021 Nov 18. PMID: 34795440 PMCID: PMC8776575
December 2021
- Fluck EC, Pumroy RA, Moiseenkova-Bell VY. Production and purification of TRPV2 and TRPV5 for structural and functional studies. Methods Enzymol. 2021;653:49-74. PMID: 34099181
- Kim J, Hong G, Mazaleuskaya L, Hsu JC, Rosario-Berrios DN, Grosser T, Cho-Park PF, Cormode DP. Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation. ACS Appl Mater Interfaces. 2021 Dec 29;13(51):60852-60864. doi: 10.1021/acsami.1c16126. Epub 2021 Dec 16. PMID: 34914872
- Lee Y, Field JM, Sehgal A. Circadian Rhythms, Disease and Chronotherapy. J Biol Rhythms. 2021 Dec;36(6):503-531. doi: 10.1177/07487304211044301. Epub 2021 Sep 22. PMID: 34547953
- Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE). Parhiz H, Brenner JS, Patel P, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora M, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson J, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov V. J Control Release. 2021 Dec 22:S0168-3659(21)00680-5. doi: 10.1016/j.jconrel.2021.12.027. Online ahead of print. PMID: 34953981
November 2021
- Kahn B, Apostolidis SA, Bhatt V, Greenplate AR, Kallish S, LaCava A, Lucas A, Meyer NJ, Negoianu D, Ogdie AR, Shashaty MGS, Takach PA, Zuroff L, Wherry EJ, Anesi GL. Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination. Crit Care Explor. 2021 Nov 5;3(11):e0578. PMID: 34765984
- Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Nat Immunol. 2021 Nov;22(11):1465. PMID: 34588688
- Brooks TG, Mrčela A, Lahens NF, Paschos GK, Grosser T, Skarke C, FitzGerald GA, Grant GR. Nitecap: An Exploratory Circadian Analysis Web Application. J Biol Rhythms. 2021 Nov 2:7487304211054408. PMID: 34724846
- Cooke M, Kreider-Letterman G, Baker MJ, Zhang S, Sullivan NT, Eruslanov E, Abba MC, Goicoechea SM, García-Mata R, Kazanietz MG. FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma. Cell Rep. 2021 Nov 2;37(5):109905. PMID: 34731623
October 2021
- Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ, Adamski S, Alam Z, Addison MM, Byrne KT, Chandra A, Descamps HC, Han N, Kaminskiy Y, Kammerman SC, Kim J, Greenplate AR, Hamilton JT, Markosyan N, Noll JH, Omran DK, Pattekar A, Perkey E, Prager EM, Pueschl D, Rennels A, Shah JB, Shilan JS, Wilhausen N, Vanderbeck AN. mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science. 2021 Oct 14:eabm0829. PMID: 34648302
- Andrews LP, Vignali KM, Szymczak-Workman AL, Burton AR, Brunazzi EA, Ngiow SF, Harusato A, Sharpe AH, Wherry EJ, Taniuchi I, Workman CJ, Vignali DAA. A Cre-driven allele-conditioning line to interrogate CD4 + conventional T cells. Immunity. 2021 Oct 12;54(10):2209-2217.e6. PMID: 34551314
- Kawakami K, Miyasaka T, Nakamura Y, Metoki H, Miyata S, Sato M, Sora I, Yamauchi K, Kawakami K, Blendy JA, Kawano T, Shimokawa H, Takayanagi M, Ohno I, Takahashi T. The A118G single-nucleotide polymorphism in OPRM1 is a risk factor for asthma severity. Allergol Int. 2021 Oct 20:S1323-8930(21)00094-0. PMID: 34688555
- Lucas A, Eberwine JH, Bagley SJ, Fan Y, Nasrallah MP, Brem S. Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and Its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing. Neurosurgery. 2021 Oct 13;89(5):E262-E263. PMID: 34332498
- Liu X, Verma A, Garcia G Jr, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW,Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2113401118. PMID: 34593624
September 2021
- Lederer K, Parvathaneni K, Painter MM, Bettini E, Agarwal D, Lundgreen KA, Weirick M, Goel RR, Xu X, Drapeau EM, Gouma S, Greenplate AR, Coz CL, Romberg N, Jones L, Rosen M, Besharatian B, Kaminiski M, Weiskopf D, Sette A, Hensley SE, Bates P, Wherry EJ, Naji A, Bhoj V, Locci M. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. medRxiv. 2021 Sep 21:2021.09.16.21263686. PMID: 34580676
- Apostolidis SA, Kakara M, Painter MM, Goel RR, Mathew D, Lenzi K, Rezk A, Patterson KR, Espinoza DA, Kadri JC, Markowitz DM, E Markowitz C, Mexhitaj I, Jacobs D, Babb A, Betts MR, Prak ETL, Weiskopf D, Grifoni A, Lundgreen KA, Gouma S, Sette A, Bates P, Hensley SE, Greenplate AR, Wherry EJ, Li R, Bar-Or A. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat Med. 2021 Sep 14. doi: 10.1038/s41591-021-01507-2. PMID: 34522051
- Chang SE, Feng A, Meng W, Apostolidis SA, Mack E, Artandi M, Barman L, Bennett K, Chakraborty S, Chang I, Cheung P, Chinthrajah S, Dhingra S, Do E, Finck A, Gaano A, Geßner R, Giannini HM, Gonzalez J, Greib S, Gündisch M, Hsu AR, Kuo A, Manohar M, Mao R, Neeli I, Neubauer A, Oniyide O, Powell AE, Puri R, Renz H, Schapiro J, Weidenbacher PA, Wittman R, Ahuja N, Chung HR, Jagannathan P, James JA, Kim PS, Meyer NJ, Nadeau KC, Radic M, Robinson WH, Singh U, Wang TT, Wherry EJ, Skevaki C, Luning Prak ET, Utz PJ. New-onset IgG autoantibodies in hospitalized patients with COVID-19. Nat Commun. 2021 Sep 14;12(1):5417. PMID: 34521836
- Chong EA, Alanio C, Svoboda J, Nasta SD, Landsburg DJ, Lacey SF, Ruella M, Bhattacharyya S, Wherry EJ, Schuster SJ. Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy. Blood. 2021 Sep 9:blood.2021012634. PMID: 34496014
- Painter MM, Mathew D, Goel RR, Apostolidis SA, Pattekar A, Kuthuru O, Baxter AE, Herati RS, Oldridge DA, Gouma S, Hicks P, Dysinger S, Lundgreen KA, Kuri-Cervantes L, Adamski S, Hicks A, Korte S, Giles JR, Weirick ME, McAllister CM, Dougherty J, Long S, D'Andrea K, Hamilton JT, Betts MR, Bates P, Hensley SE, Grifoni A, Weiskopf D, Sette A, Greenplate AR, Wherry EJ. Rapid induction of antigen-specific CD4 + T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination. Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination. Immunity. 2021 Sep 14;54(9):2133-2142.e3. PMID: 34453880
- Xu SJ, Lombroso SI, Fischer DK, Carpenter MD, Marchione DM, Hamilton PJ, Lim CJ, Neve RL, Garcia BA, Wimmer ME, Pierce RC, Heller EA. Chromatin-mediated alternative splicing regulates cocaine-reward behavior. Neuron. 2021 Sep 15;109(18):2943-2966.e8. PMID: 34480866
- Martino RA, Fluck EC 3rd, Murphy J, Wang Q, Hoff H, Pumroy RA, Lee CY, Sims JJ, Roy S, Moiseenkova-Bell VY, Wilson JM. Context-Specific Function of the Engineered Peptide Domain of PHP.B. J Virol. 2021 Sep 27;95(20):e0116421. PMID: 34346767
August 2021
- Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ. mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern. bioRxiv. 2021 Aug 23:2021.08.23.457229. PMID: 34462751
- Merenstein C, Liang G, Whiteside SA, Cobián-Güemes AG, Merlino MS, Taylor LJ, Glascock A, Bittinger K, Tanes C, Graham-Wooten J, Khatib LA, Fitzgerald AS, Reddy S, Baxter AE, Giles JR, Oldridge DA, Meyer NJ, Wherry EJ, McGinniss JE, Bushman FD, Collman RG. Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome. mBio. 2021 Aug 31;12(4):e0177721. PMID: 34399607
- Abdel-Hakeem MS, Manne S, Beltra JC, Stelekati E, Chen Z, Nzingha K, Ali MA, Johnson JL, Giles JR, Mathew D, Greenplate AR, Vahedi G, Wherry EJ. Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Nat Immunol. 2021 Aug;22(8):1008-1019. PMID: 34312545
- Elhalem E, Bellomo A, Cooke M, Scravaglieri A, Pearce LV, Peach ML, Gandolfi Donadío L, Kazanietz MG, Comin MJ. Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators. J Med Chem. 2021 Aug 12;64(15):11418-11431. PMID: 34279947
- Ahmed T, Nisler CR, Fluck EC 3rd, Walujkar S, Sotomayor M, Moiseenkova-Bell VY. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Structure. 2021 Aug 24:S0969-2126(21)00298-7. PMID: 34453887
- Swanson NA, Lokareddy RK, Li F, Hou CD, Leptihn S, Pavlenok M, Niederweis M, Pumroy RA, Moiseenkova-Bell VY, Cingolani G. Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution. Mol Cell. 2021 Aug 5;81(15):3145-3159.e7. PMID: 34214465
- Moiseenkova-Bell V, Delemotte L, Minor DL Jr. Ion Channels: Intersection of Structure, Function, and Pharmacology. J Mol Biol. 2021 Aug 20;433(17):167102. PMID: 34119491
July 2021
- Alanio C, Wherry EJ. Subsetting the subsets: Heterogeneity and developmental relationships of T cells in human tumors. Sci Immunol. 2021 Jul 23;6(61):eabj3067. PMID: 34301801
- Hou W, Ji Z, Chen Z, Wherry EJ, Hicks SC, Ji H. A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples. bioRxiv. 2021 Jul 12:2021.07.10.451910. PMID: 34282418
- Carpenter MD, Manners MT, Heller EA, Blendy JA. Adolescent oxycodone exposure inhibits withdrawal-induced expression of genes associated with the dopamine transmission. Addict Biol. 2021 Jul;26(4):e12994. PMID: 33325096
Dec 2020
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Nov 2020
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Oct 2020
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Sep 2020
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- Liwei Weng, Laurent Laboureur, Qingqing Wang, Lili Guo, Penning Xu, Leah Gottleib, David Lynch, Clementina Mesaros and Ian Blair. Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich's ataxia. Sci Rep. 2020 Sep 25;10(1):15788. PMID: 32978498 PMCID: PMC7519113.
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- Miriam Merad, Avery Posey Jr., Ofelia Olivero, Pankaj Singh, Ghassan Mouneimne, Lingyin Li, LaShanale Wallace and Tikvah Hayes. Diversity is a Strength of Cancer Research in the U.S. Cancer Cell. 2020 Sep 14;38(3):297-300.
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Aug 2020
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May 2020
April 2020
Nov 2019
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Oct 2019
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Sept 2019
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July 2019
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May 2019
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April 2019
March 2019
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