Anastassia Amaro, M.D.

Anastassia Amaro, MD is a Professor of Clinical Medicine in the Division of Endocrinology, Diabetes and Metabolism at the Perelman School of Medicine at the University of Pennsylvania. She serves as the Medical Director at the Center for Weight and Eating Disorders.

Dr. Amaro is a graduate of Sechenov Moscow Medical Academy in Moscow, Russia. She completed her internal medicine residency training at Lutheran General Hospital in Chicago, IL and fellowship training in Endocrinology, Diabetes and Metabolism at Washington University and Barnes-Jewish Hospital, St. Louis, MO. Board-certified in both Endocrinology and Obesity Medicine, Dr. Amaro is the founding director of Penn Metabolic Medicine translational center for non-surgical treatment of obesity. Her research interests include different therapeutic approaches to obesity and diabetes. 

Recent publications include:

• Caturano A, Amaro A, Berra CC, Conte C. Sarcopenic obesity and weight loss-induced muscle mass loss. Curr Opin Clin Nutr Metab Care. 2025 Apr 23. doi: 10.1097/MCO.0000000000001131. PMID: 40296814.
• Gleason E, Levine L, Lee IT, Koelper N, Amaro A, Dokras A. Effect of Glucagon-Like Peptide 1 Agonist Medications on Weight Loss in Patients with and Without Polycystic Ovary Syndrome. Fertil Steril. 2025 Apr 14:S0015-0282(25)00219-5. doi: 10.1016/j.fertnstert.2025.04.009. Epub ahead of print. PMID: 40239888.
• Wadden TA, Chao AM, Moore M, Tronieri JS, Gilden A, Amaro A, Leonard S, Jakicic JM. The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities. Curr Obes Rep. 2023 Dec;12(4):453-473. doi: 10.1007/s13679-023-00534-zPMID: 38041774; PMCID: PMC10748770.
• Amaro A, Sugimoto D, Wharton S. Efficacy and safety of semaglutide for weight management: evidence from the STEP program. Postgrad Med. 2022 Jan;134(sup1):5-17. doi: 10.1080/00325481.2022.2147326. PMID: 36691309.
• Amaro A, Kaplan M, Massie DC. Managed care considerations of weight management interventions for obesity. Am J Manag Care. 2022 Dec;28(15 Suppl):S307-S318. doi: 10.37765/ajmc.2022.89294. PMID: 36525678.