Matthew R. Hayes, Ph.D.

Albert J. Stunkard Professor in Psychiatry, Vice Chair of Basic and Translational Neuroscience Research, Director, Molecular and Neural Basis of Psychiatric Disease Section, Dept. of Psychiatry, Director of the Obesity Unit, Institute for Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania

hayesmr@pennmedicine.upenn.edu

Matthew R. Hayes, Ph.D. is the Albert J. Stunkard Professor in Psychiatry, Vice Chair of Basic and Translational Neuroscience and Director of the Molecular and Neural Basis of Psychiatric Disease Section in the Department of Psychiatry at the Perelman School of Medicine at the University of Pennsylvania. As an educator, Dr. Hayes holds a secondary appointment in the School of Nursing where he teaches core courses for the Nutrition Major at Penn. Dr. Hayes earned his Ph.D. in Nutritional Sciences from The Pennsylvania State University and conducted his postdoctoral fellowship in psychology and neuroscience at The University of Pennsylvania under the mentorship of Dr. Harvey Grill.

Hayes is considered a leading expert on the neuroendocrine systems that regulate energy balance. In particular, the Hayes laboratory focusses their research efforts extensively on understanding the neural, behavioral, cellular, molecular, and physiological mechanisms by which hormones, such as GLP-1, amylin, GIP, PYY, and leptin regulate food intake and body weight through action in the caudal brainstem and mesolimbic reward system. These basic science research efforts are conducted with the intention that they will translate into improved pharmacological / behavioral treatments for obesity, diabetes, and co-morbid diseases. Dr. Hayes has been PI / MPI on multiple NIDDK R01 awards, as well as Investigator Initiated Sponsored Proposals from pharmaceutical partners. These and other awards have supported his research into neuroendocrine controls of energy balance and obesity, with a track record of over 140 publications in this area. He has and continues to provide service as program chair and as an executive board member and scientific advisor for multiple international scientific societies, industry partners, and non-profit organizations dedicated towards neuroscience, nutrition, diabetes and obesity research / clinical care. Dr. Hayes also continues to provide service to NIH, having served on the BNRS and NORC review study sections reviewing NIH research proposals.

Hayes Lab Website

Recent publications include:

• Fortin SM, Chen JC, Petticord MC, Ragozzino FJ, Peters JH, Hayes MR. The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1. Sci Adv. 2023 Sep 22;9(38):eadh0980. doi: 10.1126/sciadv.adh0980. PMID: 37729419; PMCID: PMC10511187.
• Geisler CE, Décarie-Spain L, Loh MK, Trumbauer W, Gaisinsky J, Klug ME, Pelletier C, Davis JF, Schmidt HD, Roitman MF, Kanoski SE, Hayes MR. Amylin Modulates a Ventral Tegmental Area-to-Medial Prefrontal Cortex Circuit to Suppress Food Intake and Impulsive Food-Directed Behavior. Biol Psychiatry. 2024 May 15;95(10):938-950. doi: 10.1016/j.biopsych.2023.07.011. PMID: 37517705.
• Borner T, Reiner BC, Crist RC, Furst CD, Doebley SA, Halas JG, Ai M, Samms RJ, De Jonghe BC, Hayes MR. GIP receptor agonism blocks chemotherapy-induced nausea and vomiting. Mol Metab. 2023 Jul;73:101743. doi: 10.1016/j.molmet.2023.101743. PMID: 37245848; PMCID: PMC10326744.
• Borner T, Geisler CE, Fortin SM, Cosgrove R, Alsina-Fernandez J, Dogra M, Doebley S, Sanchez-Navarro MJ, Leon RM, Gaisinsky J, White A, Bamezai A, Ghidewon MY, Grill HJ, Crist RC, Reiner BC, Ai M, Samms RJ, De Jonghe BC, Hayes MR. GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models. Diabetes. 2021 Nov;70(11):2545-2553. doi: 10.2337/db21-0459. PMID: 34380697; PMCID: PMC8564411.
• Fortin SM, Lipsky RK, Lhamo R, Chen J, Kim E, Borner T, Schmidt HD, Hayes MR. GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats. Sci Transl Med. 2020 Mar 4;12(533):eaay8071. doi: 10.1126/scitranslmed.aay8071. PMID: 32132220; PMCID: PMC7211411.