Perelman School of Medicine at the University of Pennsylvania

White Lab

Selected Publications

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Hatterschide J, Brantly AC, Grace M, Munger K, White EA: A conserved amino acid in the C-terminus of HPV E7 mediates binding to PTPN14 and repression of epithelial differentiation. Journal of Virology. Published online June 24, 2020.

Facompre ND, Rajagopalan P, Sahu V, Pearson AT, Montone KT, James CD, Gleber‐Netto FO, Weinstein GS, Jalaly J, Lin A, Rustgi AK, Nakagawa H, Califano JA, Pickering CR, White EA, Windle B, Morgan IM, Cohen RB, Gimotty PA, Basu D: Identifying predictors of HPV‐related head and neck squamous cell carcinoma progression and survival through patient‐derived models. Int. J. Cancer. Published online June 1, 2020

White EA: Manipulation of Epithelial Differentiation by HPV Oncoproteins. Viruses. 11(4):E369. Invited review for Tenth Anniversary Issue. April 2019.

Hatterschide J, Bohidar AE, Grace M, Nulton TJ, Kim HW, Windle B, Morgan IM, Munger K, White EA: PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis. Proc Natl Acad Sci USA. 116(14):7033-7042. April 2019.

Evans MR, James CD, Bristol ML, Nulton TJ, Wang X, Kaur N, White EA, Windle B, Morgan IM: Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle. Journal of Virology. 93(4) pii: e01941-18. February 2019.

Chiang C, Pauli EK, Biryukov J, Feister KF, Meng M, White EA, Münger K, Howley PM, Meyers C, Gack MU: The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 to Suppress RIG-I-Mediated Innate Immune Signaling. Journal of Virology.  92(6) pii: e01737-17.  March 2018.

Cheng J, Park DE, Berrios C, White EA, Arora R, Yoon R, Branigan T, Xiao T, Westerling T, Federation A, Zeid R, Strober B, Swanson SK, Florens L, Bradner JE, Brown M, Howley PM, Padi M, Washburn MP, DeCaprio JA.  Merkel Cell Polyomavirus Recruits MYCL to the EP400 Complex to Promote Oncogenesis.  PLoS Pathogens. 13(10):e1006668.  October 2017.

White EA, Munger K.  Crowd Control: E7 is the Key to Cancer.  Cell 170(6):1057-1059.  September 2017.

White EA, Münger K, Howley PMHigh-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation. mBio 7(5): 5, Sep 2016.

Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BSTransformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP. J Virol 90(16): 16, Jul 2016.

White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PMPapillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. J Virol 89(5): 2857-65, Mar 2015.

Vieira VC, Leonard B, White EA, Starrett GJ, Temiz NA, Lorenz LD, Lee D, Soares MA, Lambert PF, Howley PM, Harris RSHuman papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B. mBio 5(6): 2045, Dec 2014.

Smith JA, Haberstroh FS, White EA, Livingston DM, DeCaprio JA, Howley PMSMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology 468-470: 311-21, Nov 2014.

White EA, Walther J, Javanbakht H, Howley PMGenus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes. J Virol 88(15): 8201-12, Aug 2014.

White EA, Kramer RE, Tan MJ, Hayes SD, Harper JW, Howley PMComprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol 86(24): 13174-86, Dec 2012.

Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, Howley PMCutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. Proc Natl Acad Sci USA 109(23): E1473-80, Jun 2012.

White EA, Sowa ME, Tan MJ, Jeudy S, Hayes SD, Santha S, Münger K, Harper JW, Howley PMSystematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses. Proc Natl Acad Sci USA 109(5): E260-7, Jan 2012.

Smith JA, White EA, Sowa ME, Powell ML, Ottinger M, Harper JW, Howley PM: Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc Natl Acad Sci USA 107(8): 3752-7, Feb 2010.