Rethinking Neurodegenerative Disease Treatment: Target Multiple Pathological Proteins, Not Just One
Nearly all major neurodegenerative diseases – from Alzheimer’s to Parkinson’s – are defined and diagnosed by the presence of one of four proteins that have gone rogue: tau, amyloid-beta (Aβ), alpha-synuclein (α-syn), or TDP-43. As such, investigational drugs and studies aimed at preventing or slowing the disease often hone in on just one of these respective proteins. However, targeting multiple proteins—known as “proteinopathies”—at once may be the real key, according to a recent study published in Brain by Penn Medicine researchers.
IOA IN THE NEWS
09/20/18Dr. Patrick J. Brennan understands the difficulties that millions of Americans encounter as they helplessly watch Alzheimer's…
07/27/18Finding a cure for Alzheimer’s disease has proved elusive. The drugs currently on the market only manage the symptoms of…
07/06/18Proteinopathies, the misfolded proteins responsible for neuron deaths, have a claim to fame when it comes to rare neurodegenerative…
Join the nearly 200 Institute on Aging Fellows and Associate Fellows and experience robust collaborative opportunities in aging at Penn, for funding opportunity alerts, pilot research grant opportunities, and updates on IOA activities.
FEATURED VIDEOVideo Archive
The Center for Neurodegenerative Disease Research's Marian S. Ware Research Retreat
"The Molecular Biology of Aging and Neurodegeneration"
Thursday, October 25, 2018
8:30am — 4:10pm
Biomedical Research Building (BRB) II/III
421 Curie Blvd., Philadelphia PA 19104
Learn more here!
MAKE A GIFT
Support aging-related research, education, and care at the IOA!
THE SCIENCE OF AGING NEWSLETTER
In this issue:
- Former PA Governor Rendell treated for Parkinson's at Penn
- Avoiding Heat Stress in High Summer Temps
- Rethinking Neurodegenerative Disease Treatment
… and more!
Download the 2018 Summer Newsletter here
© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.