Brain Immune System is Key to Recovery from Motor Neuron Degeneration
The selective demise of motor neurons is the hallmark of Lou Gehrig's disease, also known as amyotrophic lateral sclerosis (ALS). Yet neurologists have suspected there are other types of brain cells involved in the progression of this disorder — perhaps protection from it, which could light the way to treatment methods for the incurable disease. To get to the bottom of this question, researchers in the Perelman School of Medicine at the University of Pennsylvania engineered mice in which the damage caused by a mutant human TDP-43 protein could be reversed by one type of brain immune cell. TDP-43 is a protein that misfiles and accumulates in the motor areas of the brains of ALS patients.
IOA IN THE NEWS
08/04/17As an attorney specializing in elder law, Jerry Rothkoff sees many adult children at their wits’ ends about their parents’…
08/03/17After working with people with dementia for many years as a licensed nursing home administrator, Scott Tarde was fed up with…
07/22/17This past week, thousands of the world's leading Alzheimer's disease researchers gathered in London to discuss and debate…
Join the nearly 300 Institute on Aging Fellows and Associate Fellows and experience robust collaborative opportunities in aging at Penn, for funding opportunity alerts, pilot research grant opportunities, and updates on IOA activities.
FEATURED VIDEOVideo Archive
IOA Visiting Scholars Series
"Ubiquitin pathways in age-related neurodegeneration"
Henry Paulson, MD, PhD
Lucile Groff Professor of Neurology and Director of the Michigan Alzheimer's Disease Center
March 7, 2018
3:00 — 4:00pm
Smilow Center | Rubenstein Auditorium
MAKE A GIFT
Support aging-related research, education, and care at the IOA!
THE SCIENCE OF AGING NEWSLETTER
In this issue:
- The 2017 Joseph A. Pignolo Award in Aging Research
- New Alzheimer's Animal Model More Closely Mimics Human Disease
- Tips to avoid "cold stress"
- … and more!
© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.