George Scott Worthen

faculty photo
Professor of Pediatrics
Department: Pediatrics

Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
Education:
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
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Selected Publications

Mangalmurti N, Albelda S, Worthen GS: Stored RBCs Modulate the lung inflammatory response through necroptosis and HMGB1 release. Am J Respir Crit Care Med 190(11): 1243-1254, Dec 2014.

Gibbs J, Kearney L, Matthews L, Mei JJ, Bell T, Yang N, Saer B, Begley N, Poolman T, Pariollaud N, Farrow S, Demayo F, Hussell T, Worthen GS, Ray D, Loudon A: An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action. Nat Med 20(8): 919-926, Aug 2014.

Jaeckle Santos LJ, Li C, Doulias PT, Ischiropoulos H, Worthen GS*, Simmons RA*: Neutralizing Th2 inflammation in neonatal islets prevents β-cell failure in adult IUGR rats. Diabetes. (*Co-last authors). Diabetes 63(5): 1672-1684, May 2014.

Deshmukh H, Liu Y, Menkiti O, Mei JJ, Dai N, O’Leary C, Oliver P, Kolls J, Weiser J, Worthen GS: The microbiota regulates neutrophil homeostasis and host resistance to E. coli K1 sepsis in neonatal mice Nat Med 20(5): 524-530, May 2014.

Hudock KM, Liu Y, Mei J, Marino RC, Hale JE, Dai N, Worthen GS: Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression. Am J Respir Cell Mol Biol 47(4): 436-444, Oct 2012.

Balamayooran G, Batra S, Cai S, Mei J, Worthen GS, Penn AL, Jeyaseelan S.: Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposure. Am J Respir Cell Mol Biol 47(1): 104-111, Jul 2012.

Ramon H.E., Beal A., Liu Y., Worthen G.S., and P. M. Oliver: The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J. Immunol 188(8): 4023-4031, Apr 2012.

Mei J, Liu Y, Dai N, Hoffmann C, Hudock KM, Zhang P, Guttentag SH, Kolls JK, Oliver PM, Bushman FD, Worthen GS: Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. J Clin Invest 122(3): 974-986, Mar 2012.

Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ: IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res 71(1): 107-114, Jan 2012.

Fridlender ZG, Sun J, Mishalian I, Singhal S, Cheng G, Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM: Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PLoS One 7(2): e31524, 2012.

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Last updated: 01/28/2015
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