George Scott Worthen
Professor of Pediatrics
Department: Pediatrics
Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
Education:
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
Permanent linkAB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
Selected Publications
Hudock, Kristin M. Liu, Yuhong. Mei, Junjie. Marino, Roberta C. Hale, Jason E. Dai, Ning. Worthen, G Scott.: Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression. American Journal of Respiratory Cell & Molecular Biology 47(4): 436-44, Oct 2012.Balamayooran, Gayathriy. Batra, Sanjay. Cai, Shanshan. Mei, Junjie. Worthen, G Scott. Penn, Arthur L. Jeyaseelan, Samithamby.: Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposure. American Journal of Respiratory Cell & Molecular Biology 47(1): 104-11, Jul 2012.
Ramon, Hilda E. Beal, Allison M. Liu, Yuhong. Worthen, George Scott. Oliver, Paula M.: The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. Journal of Immunology 188(8): 4023-31, Apr 15 2012.
Mei, Junjie. Liu, Yuhong. Dai, Ning. Hoffmann, Christian. Hudock, Kristin M. Zhang, Peggy. Guttentag, Susan H. Kolls, Jay K. Oliver, Paula M. Bushman, Frederic D. Worthen, G Scott.: Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. Journal of Clinical Investigation 122(3): 974-86, Mar 1 2012.
Floros, Joanna. Londono, Douglas. Gordon, Derek. Silveyra, Patricia. Diangelo, Susan L. Viscardi, Rose M. Worthen, George S. Shenberger, Jeffrey. Wang, Guirong. Lin, Zhenwu. Thomas, Neal J.: IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatric Research 71(1): 107-14, Jan 2012.
Fridlender, Zvi G. Sun, Jing. Mishalian, Inbal. Singhal, Sunil. Cheng, Guanjun. Kapoor, Veena. Horng, Wenhwai. Fridlender, Gil. Bayuh, Rachel. Worthen, G Scott. Albelda, Steven M.: Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PLoS ONE [Electronic Resource] 7(2): e31524, 2012.
Liu, Yuhong. Mei, Junjie. Gonzales, Linda. Yang, Guang. Dai, Ning. Wang, Ping. Zhang, Peggy. Favara, Michael. Malcolm, Kenneth C. Guttentag, Susan. Worthen, G Scott.: IL-17A and TNF- exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. Journal of Immunology 186(5): 3197-205, Mar 1 2011.
Fuentes, Rudy. Wang, Yuhuan. Hirsch, Jessica. Wang, Cheng. Rauova, Lubica. Worthen, G Scott. Kowalska, M Anna. Poncz, Mortimer.: Infusion of mature megakaryocytes into mice yields functional platelets. Journal of Clinical Investigation 120(11): 3917-22, Nov 2010.
Mei, Junjie. Liu, Yuhong. Dai, Ning. Favara, Michael. Greene, Teshell. Jeyaseelan, Samithamby. Poncz, Mortimer. Lee, Janet S. Worthen, G Scott.: CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity 33(1): 106-17, Jul 23 2010.
Fridlender, Zvi G. Sun, Jing. Kim, Samuel. Kapoor, Veena. Cheng, Guanjun. Ling, Leona. Worthen, G Scott. Albelda, Steven M.: Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 16(3): 183-94, Sep 8 2009.