George Scott Worthen

faculty photo
Professor of Pediatrics
Department: Pediatrics

Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Avgousti DC, Hermann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD: A core viral protein binds host nucleosomes to sequester immune danger signals. Nature 535(7610): 173-177, Jul 2016.

Laudanski K, Qing M, Oszkiel H, Zawadka M, Lapko N, Nowak Z, Worthen GS: Ketamine affects in vitro differentiation of monocyte into immature dendritic cells. Anesthesiology 123(3): 628-641, Sept 2015.

Liu Y, O'Leary CE, Wang L-CS, Bhatti TR, Dai N, Kapoor V, Liu P, Mei JJ, Guo L, Oliver PM, Albelda SM, Worthen GS: CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis. Oncoimmunology 5(1): e1061175, Jul 2015.

Qing DY, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS: Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. Am J Respir Crit Care Med 190(11): 1243-1254, Dec 2014.

Gibbs J, Kearney L, Matthews L, Mei JJ, Bell T, Yang N, Saer B, Begley N, Poolman T, Pariollaud N, Farrow S, Demayo F, Hussell T, Worthen GS, Ray D, Loudon A: An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action. Nat Med 20(8): 919-926, Aug 2014.

Jaeckle Santos LJ, Li C, Doulias PT, Ischiropoulos H, Worthen GS*, Simmons RA*: Neutralizing Th2 inflammation in neonatal islets prevents β-cell failure in adult IUGR rats. Diabetes. (*Co-last authors). Diabetes 63(5): 1672-1684, May 2014.

Deshmukh H, Liu Y, Menkiti O, Mei JJ, Dai N, O’Leary C, Oliver P, Kolls J, Weiser J, Worthen GS: The microbiota regulates neutrophil homeostasis and host resistance to E. coli K1 sepsis in neonatal mice Nat Med 20(5): 524-530, May 2014.

Hudock KM, Liu Y, Mei J, Marino RC, Hale JE, Dai N, Worthen GS: Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression. Am J Respir Cell Mol Biol 47(4): 436-444, Oct 2012.

Balamayooran G, Batra S, Cai S, Mei J, Worthen GS, Penn AL, Jeyaseelan S.: Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposure. Am J Respir Cell Mol Biol 47(1): 104-111, Jul 2012.

Ramon H.E., Beal A., Liu Y., Worthen G.S., and P. M. Oliver: The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J. Immunol 188(8): 4023-4031, Apr 2012.

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Last updated: 07/27/2016
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