Perelman School of Medicine at the University of Pennsylvania

Center for Sleep and Circadian Neurobiology

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Penn Sleep Annual Research Retreat

For over a decade, the CSCN has hosted an annual research retreat with the aim of promoting sleep medicine and circadian neurobiology research. Since 2015, the Penn Chronobiology Program has partnered with the CSCN to host a joint research retreat.

 

2017 Retreat — Save the Date

2016 Retreat Sessions

To celebrate the 25th anniversary of the CSCN, the 2016 retreat featured alumni talks on the Functions of Sleep, Circuits, OSA & Sleep Fragmentation, Genetics of Sleep, and Sleep Loss. There were also special remarks by Dean Larry Jameson, MD, PhD.

 

Functions of Sleep

  • Dr. Matthew Kayser Sleep Deprivation Suppresses Aggression in Drosophila
  • Dr. Sara Aton Sleep Dependent Memory Consolidation: Oscillation and Ensembles        
  • Dr. David Raizen Sleep Functions: Lessons from a Round Worm

Circuits

  • Dr. Daniel Cavanaugh The Drosophila Circadian Clock Gates Sleep Timing through Interactions with Sleep-Promoting Neurons
  • Dr. Mark Wu Sleep Drive is Encoded by Neural Plastic Changes in a Dedicated Circuit

OSA and Sleep Fragmentation

  • Dr. Richard Schwab Important Insights into Sleep Apnea from Upper Airway Imaging    
  • Dr. Sigrid Veasey A Sleep Loss Locus for Alzheimer’s Disease
  • Dr. Ulysses Magalang Sleep Apnea and Metabolic Dysfunction
  • Dr. Richard Horner Mechanisms of REM Sleep

Genetics of Sleep

  • Dr. Phil Gehrman Gene and Biomarkers of Insomnia
  • Dr. Susan Harbison Sleep in Drosophila Melanogaster: Insights Gained from a Systems Genetics Approach
  • Dr. Kyunghee Koh Sexually Dimorphic Regulation of Sleep in Drosophila

Sleep Loss

  • Dr. Mathias Basner Identifying and Mitigating Sleep Restriction on Earth and in Space
  • Dr. Hans Van Dongen Sleep Deprivation,  Feedback Blunting and Dopaminergic Gene Polymorphisms
  • Dr. Janet Mullington Effects of Repeated Sleep Restriction Challenge with Little Intervening Recovery Opportunity, on Autonomic and Inflammatory Parameters
  • Dr. William Joiner Molecular and Neuroanatomical Control of Sleep Drive in Drosophila

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2015 Retreat Sessions & Abstracts

KEYNOTE SPEAKER

William J. Schwartz, MD, Professor of Medicine, University of Massachusetts Medical School, Department of Neurology

 

SLEEP DISORDERS AND SLEEP LOSS

Wailuddin S. Khadeer “Use of Mobile Electronic Devices in Bed Associated with Sleep Duration, Insomnia, and Daytime Sleepiness”
Olga Tkachenko “The Impact of Recovery Sleep Opportunity on Neurobehavioral Measures Following Chronic Sleep Restriction”
Margaret C. Souders “Pilot Study of a Tailored Behavioral Intervention for Insomnia in Children with Autism Spectrum Disorder: Preliminary Results”
Christopher Cielo “Restless Legs Syndrome in Children with a History of Prematurity”
Enda M. Byrne “Shared Genetic Risk Factors between Schizophrenia and Subjective Sleep Quality and Duration in a Population-based Cohort of Australian Twins”
 

SLEEP, ENERGY AND METABOLISM

Stephen Wang “Effect of Weight-loss on Tongue Fat and Upper Airway Structures”
Arjun Sengupta “Estimation of Brain Response During Sleep from Serum Metabolome by NMR Spectroscopy”
Isaac J. Perron “Diet/Energy Balance Affect Sleep and Wakefulness Independent of Body Weight”
Sarah C. McLoughlin “Exercise Training Affects Metabolic and Locomotion Deficits of BMAL1 Prenatal Knockout Mice”

 

BASIC SLEEP AND CIRCADIAN SCIENCE

Nicholas F. Trojanowski “Distinct Mechanisms Underlie Two Types of Caenorhabditis Elegans Sleep”
David S. Garbe “Sex Differences in Drosophila Sleep Patterns”
Jennifer C. Tudor “Increasing Protein Synthesis in the Hippocampus Prevents Cognitive Impairments Caused by Sleep Deprivation”

 

ALL 2015 CSCN RETREAT ABSTRACTS

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2014 Retreat Sessions & Abstracts

KEYNOTE SPEAKER

Michael Rosbash, PhD, Peter Gruber Endowed Chair in Neuroscience, Howard Hughes Medical Institute Investigator
 

SLEEP, HEALTH, AND ENVIRONMENTAL INFLUENCES

Michael A. Grandner “The Relationship between Sleep Duration and Cardiometabolic Risk Factors Depends on Race/Ethnicity and Whether Risk Factors Were Self-Reported or Objectively-Determined”
Jesse Schuschu “The Relationship Between Race/Ethnicity and Sleep Duration Depends on Geographic Location”
Mathias Basner “Inter-individual differences in the effects of aircraft noise on sleep fragmentation”
Andrea Spaeth “Baseline Slow-Wave Sleep Negatively Relates to Energy Balance Responses during Sleep Restriction in Healthy Adults”
Matthew Kayser “A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila”

 

ADVANCES IN SLEEP DISORDERS AND INTERVENTION RESEARCH 

Sheila Garland “A Randomized Trial of Cognitive Behavior Therapy and Armodafinil to Treat Insomnia and Daytime Sleepiness in Cancer Survivors”
Carole Marcus “Long-Term Effects of Caffeine Therapy for Apnea of Prematurity on Sleep”
Renata Pellegrino “A Genome-wide Association Study of Apnea-Hypopnea Index in Children with Obstructive Breathing”
McKinstry-Wu “Inhibition of the Locus Coeruleus Impedes Emergence from Alkylphenol Hypnosis”

 

CIRCADIAN GENETICS 

Sarah McLoughlin “Diurnal changes in autophagy and the role of the clock”
Heather Balance “Orchestrated Signal Transduction Unites Mammalian Circadian Metabolism Across Tissues”
Brian Altman “Rev-erbα Modulates Myc-Driven Cancer Cell Growth and Altered Metabolism”
Daniel Cavanaugh “Identification of a circadian output circuit for rest:activity rhythms in Drosophila”
Shailesh Kumar “An ecdysone-responsive nuclear receptor impacts circadian rhythms in Drosophila”

 

ALL 2014 CSCN RETREAT ABSTRACTS

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2013 Retreat Sessions & Abstracts

KEYNOTE SPEAKER

Joseph Takahashi, PhD, Loyd B. Sands Distinguished Chair in Neuroscience,University of Texas Southwestern

 

SLEEP & NEURODEGENERATION

Jason Gerstner “Amyloid-beta Induced Sleep Fragmentation is Rescued by Fatty-acid Binding Proteins in Drosophila”
Marishka Brown “Aging Induced ER Stress Alters Sleep and Sleep Homeostasis”
Lama Chahine “Questionnaire-based Diagnosis of REM Sleep Behavior Disorder in Parkinson’s Disease”
 

OBSTRUCTIVE SLEEP APNEA, OBESITY & METABOLISM

Julio Chirinos “A Randomized Trial of Continuous Positive Airway Pressure Therapy, Weight Loss, orBoth for Obese Adults with Obstructive Sleep Apnea”
Victoria Pak “Obstructive Sleep Apnea, Obesity and Cellular Adhesion Molecules: Impact of2 Years of CPAP Treatment”
Beverly Shin “Respiratory-Related Dynamic Upper Airway Changes in Obese Apneics after Weight Loss”
Zhou Fang “Enhanced Resting-State Striatal Connectivity Correlates with Increases in Daily CaloricIntake afterSleep Deprivation”

 

NEUROANATOMY & FUNCTIONAL CONNECTIONS 

Robbert Havekes “Sleep Deprivation Impairs Memory by Altering Cofilin and Actin Signaling”
Hilary McCarren “Stimulation of the α2a Adrenergic Receptor in the Ventrolateral Preoptic Area Promotes Arousal”
Anand Venkataraman “Bmal1fbrainKO Mice Exhibit Deficits in Learning and Memory Processes”
Matthew Nelson “The Molecular Logic of C. elegans Sleep: A Single Sleep-Promoting Neuron Inhibits a Wake-Promoting Pair of Neurons via Neuropeptide Signaling”
 
 

CIRCADIAN/HOMEOSTATIC SLEEP

Brian Altman “Oncogenic c- and N-Myc Disrupt Circadian Rhythm”
Mathias Basner “A Randomized Trial of a 3-hour Protected Nap Period in Medical Interns”
David Garbe “Cooperative Interaction between Phosphorylation Sites on PERIOD Maintains Circadian Period in Drosophila”

 

ALL 2013 CSCN RETREAT ABSTRACTS

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2010 Retreat Abstracts

KEYNOTE SPEAKER

Dr. Juliane Winkelmann – Max Planck Institute for Psychiatry


ALL 2010 CSCN RETREAT ABSTRACTS

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2007 Retreat Abstracts

KEYNOTE SPEAKER

H. Craig Heller


ALL 2007 CSCN RETREAT ABSTRACTS

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2006 Retreat Abstracts

KEYNOTE SPEAKER

Charles A. Czeisler, M.D.,Ph.D., Frank Baldino, Jr., Ph.D. Professor of Sleep Medicine, Harvard University


ALL 2006 CSCN RETREAT ABSTRACTS

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2005 Retreat Abstracts


2004 Retreat Abstracts