Pathogenesis and experimental therapeutics of complement-mediated inflammatory, autoimmune and thrombotic vasculopathy diseases
complement, gene targeting, mouse model, innate immunity, inflammation, autoimmunity, C3 glomerulonephritis (C3GN), hemolytic uremic syndrome (HUS), dense deposit disease (DDD), age-related macular degeneration (AMD),antibody and gene therapy
My research is focused on complement-mediated inflammatory, autoimmune and thrombotic vasculopathy disorders. By creating gene targeted mice, we establish mouse models of human diseases to understand disease pathogenesis and to test novel anti-complement therapies. We are also interested in the interaction of complement with other innate immune pathways such as the Toll-like receptors and with the adaptive immune system. Our long term goal is to advance basic complement immunology and to help develop new therapies for complement-mediated human diseases.
ROTATION PROJECTS (Please inquire).
Ueda Yoshiyasu, Mohammed Imran, Song Delu, Gullipalli Damodar, Zhou Lin, Sato Sayaka, Wang Yuan, Gupta Shuchi, Cheng Zhongjian, Wang Hong, Bao Jialing, Mao Yingying, Brass Lawrence, Zheng X Long, Miwa Takashi, Palmer Matthew, Dunaief Joshua, Song Wen-Chao: Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. Blood 129(9): 1184-1196, Mar 2017.
Williams Allison Lesher, Gullipalli Damodar, Ueda Yoshiyasu, Sato Sayaka, Zhou Lin, Miwa Takashi, Tung Kenneth S, Song Wen-Chao: C5 inhibition prevents renal failure in a mouse model of lethal C3 glomerulopathy. Kidney international 91(6): 1386-1397, Jun 2017.
Facciabene Andrea, De Sanctis Francesco, Pierini Stefano, Reis Edimara S, Balint Klara, Facciponte John, Rueter Jens, Kagabu Masahiro, Magotti Paola, Lanitis Evripidis, DeAngelis Robert A, Buckanovich Ronald J, Song Wenchao C, Lambris John D, Coukos George: Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy. Oncoimmunology 6(9): e1326442, 2017.
Song Delu, Sulewski Michael E, Wang Chenguang, Song Jiantao, Bhuyan Rupak, Sterling Jacob, Clark Esther, Song Wen-Chao, Dunaief Joshua L: Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration. Molecular vision 23: 210-218, 2017.
Bergfeld Arne, Dasari Prasad, Werner Sandra, Hughes Timothy R, Song Wen-Chao, Hortschansky Peter, Brakhage Axel A, Hünig Thomas, Zipfel Peter F, Beyersdorf Niklas: Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4(+) T Cells. Frontiers in microbiology 8: 844, 2017.
Song Delu, Wilson Brooks, Zhao Liangliang, Bhuyan Rupak, Bandyopadhyay Mausumi, Lyubarsky Arkady, Yu Chen, Li Yafeng, Kanu Levi, Miwa Takashi, Song Wen-Chao, Finnemann Silvia C, Rohrer Bärbel, Dunaief Joshua L: Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration. PloS one 11(11): e0166348, 2016.
Ueda Yoshiyasu, Gullipalli Damodar, Song Wen-Chao: Modeling complement-driven diseases in transgenic mice: Values and limitations. Immunobiology 221(10): 1080-90, Oct 2016.
Wang Yuan, Miwa Takashi, Ducka-Kokalari Blerina, Redai Imre G, Sato Sayaka, Gullipalli Damodar, Zangrilli James G, Haczku Angela, Song Wen-Chao: Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation. Journal of immunology (Baltimore, Md. : 1950) 195(3): 1171-81, Aug 2015.
Song Di, Yu Xiao-Juan, Wang Feng-Mei, Xu Bing-Ning, He Ying-Dong, Chen Qian, Wang Su-Xia, Yu Feng, Song Wen-Chao, Zhao Ming-Hui: Overactivation of Complement Alternative Pathway in Postpartum Atypical Hemolytic Uremic Syndrome Patients with Renal Involvement. American journal of reproductive immunology (New York, N.Y. : 1989) 74(4): 345-56, Oct 2015.
Miao Jing, Lesher Allison M, Miwa Takashi, Sato Sayaka, Gullipalli Damodar, Song Wen-Chao: Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia-reperfusion injury. Kidney international 86(4): 726-37, Oct 2014.
back to top
Last updated: 07/06/2021
The Trustees of the University of Pennsylvania