Food allergy, Eosinophilic esophagitis, Severe allergy/anaphylaxis
The Hill Lab uses clinical and epidemiological data to guide mechanistic studies in disease models and human samples. Our work focuses on the two most common chronic diseases of childhood: allergy and obesity. Our wet-lab research falls broadly into the scientific fields of experimental immunology, cell and molecular biology, genomics, and transcriptional regulation. By having in-house expertise in both clinical informatics and traditional wet-lab techniques, we are optimally situated to translate our observations from the clinic, to the bench, and back.
Successful examples of this approach include:
Discerning microbiologic and immunologic mechanisms that explain epidemiological links between commensal-altering environmental stimuli (antibiotic/microbial exposure, cesarean section, feeding practices) and worse allergic outcomes.
Identification of eosinophilic esophagitis as a member of the allergic march, and studies of the immunologic basis for this connection.
Understanding the inflammatory link between obesity/western diet and inflammatory comorbidities (allergy, atherosclerosis, cancer, etc.).
We are always open to collaboration and meeting with potential new lab members. If you would like to contact the lab, drop us an email: HillLab@email.chop.edu.
Gabryszewski SJ, Dudley J, Grundmeier, RW, Hill DA: Delivery Mode and Feeding Practices Influence Allergic Disease Burden. Annals of Allergy, Asthma & Immunology 123(5): S56, Nov 2019.
Ruffner, MA, Wang KY, Dudley JW, Cianferoni A, Grundmeier RW, Spergel JM, Brown-Whitehorn TF, Hill DA: Elevated Allergic Comorbidity in Patients with Food Protein-Induced Enterocolitis. Annals of Allergy, Asthma & Immunology 123(5): S9, Nov 2019.
Hill DA, Romberg N: Primary Immunodeficiencies and Cytokine Storm Syndromes. Cytokine Storm Syndrome. Cron R, Behrens E (eds.). Springer, Cham, 1(5): 209-232, Sep 2019.
Hill DA: Reflux and failure to thrive. Pediatric Allergy: A Case-Based Collection with MCQs. Rezaei N (eds.). Springer, Cham, 1(20): 101-105, Aug 2019.
Bosticardo M, Yamazaki Y, Cowan J, Giardino G, Corsino C, Scalia G, Prencipe R, Ruffner M, Hill DA, Sakovich I, Yemialyanava I, Tam JS, Padem N, Elder ME, Sleasman JW, Perez E, Niebur H, Seroogy CM, Sharapova S, Gebbia J, Kleiner GI, Peake J, Abbott JK, Gelfand EW, Crestani E, Biggs C, Butte MJ, Hartog N, Hayward A, Chen K, Heimall J, Seeborg F, Bartnikas LM, Cooper MA, Pignata C, Bhandoola A, Notarangelo LD: Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis. American Journal of Human Genetics Aug 2019.
Jaitin Diego Adhemar, Adlung Lorenz, Thaiss Christoph A, Weiner Assaf, Li Baoguo, Descamps Hélène, Lundgren Patrick, Bleriot Camille, Liu Zhaoyuan, Deczkowska Aleksandra, Keren-Shaul Hadas, David Eyal, Zmora Niv, Eldar Shai Meron, Lubezky Nir, Shibolet Oren, Hill David A, Lazar Mitchell A, Colonna Marco, Ginhoux Florent, Shapiro Hagit, Elinav Eran, Amit Ido: Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. Cell Jun 2019.
Ruffner MA, Capucilli P, Hill DA, Spergel JM: Screening children for eosinophilic esophagitis: allergic and other risk factors. Expert Review of Clinical Immunology 15(4): 315-318, Apr 2019.
David A. Hill; Consultant360: The Atopic March: Is There a Fifth Member? Podcast Mar 2019.
Capucilli P, Hill DA: Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications. Clinical Reviews in Allergy & Immunology Mar 2019.
David A. Hill; Consultant360: The Atopic March: Key Takeaways for Pediatricians. Podcast Mar 2019.
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Last updated: 11/26/2019
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