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David A. Hill, MD, PhD, FAAP, FACAAI, FAAAAI
5bAssistant Professor of Pediatrics (Allergy/Immunology)
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Department: Pediatrics
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Graduate Group Affiliations
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- Immunology 6b
- Cell and Molecular Biology e
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Contact information
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Children's Hospital of Philadelphia
2a Division of Allergy and Immunology
20 Department of Pediatrics
36 Abramson Pediatric Research Center, Room 1208B
3a 3615 Civic Center Blvd.
Philadelphia, PA 19104
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2a Division of Allergy and Immunology
20 Department of Pediatrics
36 Abramson Pediatric Research Center, Room 1208B
3a 3615 Civic Center Blvd.
Philadelphia, PA 19104
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Office: 215-590-2549
32 Fax: 215-590-6849
32 Lab: 267-426-7777
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32 Fax: 215-590-6849
32 Lab: 267-426-7777
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Publications
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Education:
21 7 BS 2d (Biological Sciences, with honors) c
48 Carnegie Mellon University, Elizabeth Jones Lab, 2005.
21 8 PhD 27 (Cell and Molecular Biology) c
57 University of Pennsylvania School of Medicine, David Artis Lab, 2011.
21 7 MD 15 (Medicine) c
46 University of Pennsylvania School of Medicine, 2013.
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21 7 BS 2d (Biological Sciences, with honors) c
48 Carnegie Mellon University, Elizabeth Jones Lab, 2005.
21 8 PhD 27 (Cell and Molecular Biology) c
57 University of Pennsylvania School of Medicine, David Artis Lab, 2011.
21 7 MD 15 (Medicine) c
46 University of Pennsylvania School of Medicine, 2013.
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Post-Graduate Training
24 85 Post-Baccalaureate IRTA Fellow, National Institute of Allergy and Infectious Diseases, Sanjay Desai Lab, 2005-2006.
24 60 Clinical Resident, Pediatrics, Children's Hospital of Philadelphia, 2013-2016.
24 83 Clinical Fellow, Allergy and Immunology, Children's Hospital of Philadelphia, Jonathan Spergel mentor, 2016-2018.
24 62 Post-Doctoral Fellow, University of Pennsylvania, Mitchell Lazar Lab, 2016-2019.
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Permanent link24 85 Post-Baccalaureate IRTA Fellow, National Institute of Allergy and Infectious Diseases, Sanjay Desai Lab, 2005-2006.
24 60 Clinical Resident, Pediatrics, Children's Hospital of Philadelphia, 2013-2016.
24 83 Clinical Fellow, Allergy and Immunology, Children's Hospital of Philadelphia, Jonathan Spergel mentor, 2016-2018.
24 62 Post-Doctoral Fellow, University of Pennsylvania, Mitchell Lazar Lab, 2016-2019.
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Description of Clinical Expertise
52 Food allergy, eosinophilic esophagitis, obesity-associated asthma.71
Description of Research Expertise
230 The Hill Lab investigates how diet and metabolism impact immune health and contribute to inflammatory diseases. Our research focuses on key areas such as food allergies, obesity-associated asthma, and immunometabolism. By integrating clinical epidemiology with mechanistic studies in animal models and patient samples, we aim to uncover the underlying mechanisms that drive immune responses. Our goal is to translate these findings into innovative preventative, diagnostic, and therapeutic strategies to improve human health and combat disease.e 29
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f0 McCright SJ, Harding O, Hill DA: Dietary saturated fatty acids as evolutionarily conserved signals of immune activation. DNA and Cell Biology Page: In Press, Mar 2026.
17d Dilollo J, Hu A, Spergel JM, Cerosaletti K, Hill DA: A Pathogenic Transcriptional Signature of Milk-Specific T Cells in Eosinophilic Esophagitis. 2026 AAAAI Annual Meeting Advances and Ongoing Challenges in Eosinophilic Gastrointestinal Disorders: Organized by CEGIR/TIGERS Feb 2026 Notes: Oral presentation.
11d Pandey D, Chini J, McCright S, Hill DA: The role of CD9 in regulating metabolic dysfunction and tissue inflammation during obesity. 2026 AAAAI Annual Meeting Discovery Session Feb 2026 Notes: Poster presentation.
10f Puzon NV, McCright SJ, Harding O, Hill DA: Mechanisms of dietary fatty acid-induced pulmonary eosinophil recruitment. 2026 AAAAI Annual Meeting Discovery Session Feb 2026 Notes: Poster presentation.
119 Dilollo J, Hu A, Spergel JM, Cerosaletti K, Hill DA: A Pathogenic Transcriptional Signature of Milk-Specific T Cells in Eosinophilic Esophagitis. 2026 AAAAI Annual Meeting Feb 2026 Notes: Poster presentation.
15a Dilollo J, Guerrier CM, De La Torre ISR, Martin E, Lee S, Pratt M, Vinnakota P, Faig W, Paessler ME, Spergel JM, Hill DA (corresponding): Evaluation of Functional T-Cell Assays that Predict Causal Allergens in Eosinophilic Esophagitis. Diagnostics Page: In Press, Jan 2026.
136 Chini J, DeMarco N, Mitchell DV, McCright SJ, Shen KM, Pandey D, Clement RL, Miller J, Jain R, Taylor DM, Lazar MA, Hill DA: CD9 regulates macrophage-mediated remodeling of adipose tissue in obesity. JCI Insight Page: In Press, Jan 2026.
1ab Rodríguez-López E, Clement RL, Lal M, Zhou Y, Carro SD, Assenmacher CA, Gautam R, Beers J, Muir AB, Spergel JM, Ruffner MA, Eisenlohr LC, Hill DA (corresponding): Oesophageal epithelial cell-intrinsic MHCII regulates food antigen-dependent eosinophilic esophagitis in an IFNγ-dependent manner. Clinical & Experimental Allergy Page: In press, Dec 2025.
f2 Hill DA: Explaining Divergent Food Allergy Phenotypes Through Failures in T and B Cell Tolerance. Journal of Allergy and Clinical Immunology 156(6): 1511-1513, Dec 2025.
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Selected Publications
1c1 Kuprasertkul N, D’souza CA, Huang S, Chini J, Egolf S, Moore AF, Pinheiro LV, Jaccard A, Magahis CT, Bao L, Aubert Y, Olingou C, Prouty SM, Brennan-Crispi D, Hill DA, Seykora JT, Wellen KE, Capell BC: Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression. The Journal of Clinical Investigation Page: In Press, Mar 2026.f0 McCright SJ, Harding O, Hill DA: Dietary saturated fatty acids as evolutionarily conserved signals of immune activation. DNA and Cell Biology Page: In Press, Mar 2026.
17d Dilollo J, Hu A, Spergel JM, Cerosaletti K, Hill DA: A Pathogenic Transcriptional Signature of Milk-Specific T Cells in Eosinophilic Esophagitis. 2026 AAAAI Annual Meeting Advances and Ongoing Challenges in Eosinophilic Gastrointestinal Disorders: Organized by CEGIR/TIGERS Feb 2026 Notes: Oral presentation.
11d Pandey D, Chini J, McCright S, Hill DA: The role of CD9 in regulating metabolic dysfunction and tissue inflammation during obesity. 2026 AAAAI Annual Meeting Discovery Session Feb 2026 Notes: Poster presentation.
10f Puzon NV, McCright SJ, Harding O, Hill DA: Mechanisms of dietary fatty acid-induced pulmonary eosinophil recruitment. 2026 AAAAI Annual Meeting Discovery Session Feb 2026 Notes: Poster presentation.
119 Dilollo J, Hu A, Spergel JM, Cerosaletti K, Hill DA: A Pathogenic Transcriptional Signature of Milk-Specific T Cells in Eosinophilic Esophagitis. 2026 AAAAI Annual Meeting Feb 2026 Notes: Poster presentation.
15a Dilollo J, Guerrier CM, De La Torre ISR, Martin E, Lee S, Pratt M, Vinnakota P, Faig W, Paessler ME, Spergel JM, Hill DA (corresponding): Evaluation of Functional T-Cell Assays that Predict Causal Allergens in Eosinophilic Esophagitis. Diagnostics Page: In Press, Jan 2026.
136 Chini J, DeMarco N, Mitchell DV, McCright SJ, Shen KM, Pandey D, Clement RL, Miller J, Jain R, Taylor DM, Lazar MA, Hill DA: CD9 regulates macrophage-mediated remodeling of adipose tissue in obesity. JCI Insight Page: In Press, Jan 2026.
1ab Rodríguez-López E, Clement RL, Lal M, Zhou Y, Carro SD, Assenmacher CA, Gautam R, Beers J, Muir AB, Spergel JM, Ruffner MA, Eisenlohr LC, Hill DA (corresponding): Oesophageal epithelial cell-intrinsic MHCII regulates food antigen-dependent eosinophilic esophagitis in an IFNγ-dependent manner. Clinical & Experimental Allergy Page: In press, Dec 2025.
f2 Hill DA: Explaining Divergent Food Allergy Phenotypes Through Failures in T and B Cell Tolerance. Journal of Allergy and Clinical Immunology 156(6): 1511-1513, Dec 2025.
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Contact us
4eInstitute for Diabetes, Obesity and Metabolism
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Smilow Center for Translational Research
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3400 Civic Center Boulevard, 12th Floor
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Philadelphia, PA 19104
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Phone: 215-898-0198 | Fax 215-898-5408
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Directions
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© Trustees of the University of Pennsylvania
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