Photon SARRP

Recently, a new SARRP platform was made available to the facility by funds from the Mark Foundation and Andy J. Minn, MD, PhD. The third generation Small Animal Radiation Research Platform (SARRP) is equipped with high resolution CT panel, motorized variable collimator (MVC), 360 degree rotating gantry, set of standard fixed collimators, heated rodent positioning stages and advanced treatment planning software (TPS). The new SARRP offers the ability to acquire cone-beam computed tomographic imaging (CBCT) of rodents with variable voxel resolution down to 0.007 mm and image guided radiation therapy (IGRT) with isocenteric targeting accuracy of 0.25 mm." on the CARC equipment page under "Photon SARRP


The SARRP research platform has a flexibility of design that will meet any initial specification, and allows individual user groups to add on supporting imaging technologies to meet their future research needs—enabling continual system adaptation to facilitate the development of new and innovative applications.
The repositionable product frame and automatically rotatable specimen stage allow radiation to be delivered at multiple angles without the need to reposition the specimen between exposures.

Photon Saarp\

The third generation SARRP System Features

  • Isocenteric targeting accuracy of 0.25 mm
  • On board cone beam CT and image reconstruction
  • Minimum field size of 0.5 mm in diameter
  • Higher resolution (up to 70 micron) CBCT panel for kV imaging
  • Temperature controlled rodent positioning stages to maintain physiological temperatures for rodents during longer irradiating sessions 
  • 360 degree isocentric gantry rotation and robotic specimen stage enable non-coplanar field arrangements
  • Motorized variable collimator (MVC)
  • Integrated shielding design

SARRP Research Platform Advantages

  • Provides state-of-the-art 3D volumetric image guidance for localization and targeting of the dose
  • Conformal dose minimizes exposure to non-targeted tissues and organs
  • Non-invasive procedure
  • Easy to use, reliable, and reproducible
  • Customizable to meet new and innovative applications
  • High resolution, low imaging dose, on board CT imaging and 3D reconstruction
  • Image fusion options for easy target localization and avoidance of organs at risk
  • High precision beam geometry to achieve conformal dose distributions
  • Open platform to enable the addition of other imaging modalities for future research


The SARRP research platform enables researchers to replicate the radiotherapy process of imaging, target localization and radiotherapy treatment delivery techniques employed when treating patients in clinical oncology departments. In order to improve the efficiency of radiation therapy and minimize the short and long term side effects of cancer treatment it is vital to study radiation biology using in vivo models.

  • Radiobiology
  • Preclinical studies
  • DNA damage response
  • Tumor biology and the micro-environment
  • Bystander effects
  • Radiosensitizers
  • Cardiovascular toxicity
  • Oncology research
  • Preclinical validation of radiotherapy – assessing the risks of radiation exposure balanced against the efficacy of the treatment in controlling and eliminating tumors
  • Normal tissue injury by radiotherapy
  • Immunology disease
  • Cardiovascular diseases
  • Radiobiological effectiveness
  • Characterize tumors that may not respond to ionizing radiation
  • DNA damage response
  • Can couple spatially targeted radiotherapy with molecularly targeted therapies to optimize treatments for solid tumors
  • Mechanism of tumor control