The CAROT Research Vector Core generates, Shangzhen Zhou, M.D., Director, generates high titer and highly purified recombinant adeno-associated virus (AAV) vectors for use in preclinical studies. The core generates AAVs of a variety of different serotypes and works with investigators to tailor production to meet project requirements.
Shangzhen Zhou, M.D.
Dr. Shangzhen Zhou is the Director of the CAROT Research Vector Core (RVC) and has more than 3.5 decades experience in biomedical research. She earned her M.D. from Hunan Medical University, China, and trained in gene therapy research at Indiana University. She is an internationally recognized expert in AAV gene therapy research, particularly in innovations of AAV viral vector production. She was instrumental in developing the first high titer vector production method with a rapid, serotype-independent, low cost, and high yield purification protocol. Prior to joining CAROT, Dr. Zhou directed the RVC at The Children’s Hospital of Philadelphia (where she worked with CAROT and CHOP investigators to develop the first batch of AAV that would become “Luxturna”). Prior to CHOP, she worked at Avigen and Somatix and served as principal scientist at Chiron (now Novartis).
Jieyan Pan, Ph.D.
Dr. Jieyan Pan is an expert in generation and purification of recombinant adeno-associated virus (AAV) for use in gene therapy studies. Dr. Pan also serves as manager of the CAROT AAV research vector core. He graduated from Nanjing Agricultural University with a major in Animal Microbiology and pursued postdoctoral training at University of Utah, UPenn and CHOP. His postdoctoral training included studies of coxsackievirus infection, virus and receptor interactions, and virus entry into cells. Dr. Pan is interested in using AAV as a tool to cure human diseases.
Xiaolu is a Research Specialist in CAROT Research vector center. She joined since 2016. She cooperate with other members for vector develop.
Miao joined the CAROT Research vector center in April 2019. She is broadly interested in molecular and computational biology. She loves learning and developing new technology.
James has been apart of the CAROT vector since 2017. He facilitates the purification of vectors. James also enjoys various outdoor activities.