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Publications

  1. Cleveland AH, Fan Y.   Reprogramming endothelial cells to empower cancer immunotherapy. Trends in Molecular Medicine 2024 in press.

  2. Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y*, Fan Y*.    Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy. Nature Protocols *Co-senior authors. 2024 in press.

  3. Yang F, Zhang D, Jiang H, Ye J, Zhang L, Winkler J, Gong Y, & Fan Y.    Small-molecule reversal of macrophage-mediated immunosuppression overcomes glioblastoma resistance to immunotherapy. Science Translational Medicine 15: eabq3558, Feb 2023.

  4. Zhang D, Li A, Huang M, Yang F, Zhang L, Wellen KE, Xu X, Conn CS, Zou W, Kahn M, Rhoades SD, Weljie AM, Amankulor N, Yoshor D, Ye J, Koumenis C, Gong Y, & Fan Y.  PHGDH-mediated endothelial metabolism drives glioblastoma resistance to CAR T cell immunotherapy. Cell Metabolism 35: 1-18, Feb 2023.

  5. Huang M, Yang F, Zhang D, Lin M, Duan H, EI-Mayta R, Zhang L, Qin L, Shewale S, Pei L, Mitchell M, Rader D, Fan Y*, Gong Y*.    Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Nature Cardiovascular Research 1(4): 372–388, *Co-senior author. Apr 2022

  6. Ma W, Wang Y, Zhang R, Yang F, Zhang D, Huang M, Zhang L, Dorsey JF, Binder ZA, O’Rourke DM, Fraietta JA, Gong Y*, Fan Y*.    Targeting PAK4 to reprogram vascular microenvironment and improve CAR T immunotherapy for glioblastoma. Nature Cancer 2: 83–97, *Co-corresponding authors. February 2021.

  7. Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH*, Gong Y*, & Fan Y*. Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Comm. 12(1): 3424, *Co-corresponding authors. June 2021

  8. Huang M, Zhang D, Wu JY, Xing K, Yeo E, Li C, Zhang L, Holland E, Yao L, Qin L, Binder ZA, O’Rourke DM, Brem S, Koumenis C, Gong Y, and Fan Y.    Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Science Translational Medicine 12(532): eaay7522, Feb 2020.

  9. Fan Y.   Vascular Detransformation for Cancer Therapy. Trends in Cancer 5(8): 460-463, August 2019.

  10. Liu T, Ma W, Xu H, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, and Fan Y.    PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nature Comm 9(1): 3439, August 2018.

  11. Wang Q, He Z, Huang M, Liu T, Xu H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O’Rourke DM, Dahmane N, Brem S, Gong Y, & Fan Y.    Vascular niche IL-6 induces macrophage M2 polarization in gliomblastoma through HIF-2α. Nature Comm 9(1): 559, February 2018.

  12. Huang M, T Liu, Ma P, Mitteer RA, Zhang Z, Kim HJ, Yeo E, Zhang D, Cai P, Li C, Zhang L, Zhao B, Roccograndi L, O’Rourke DM, Dahmane N, Gong Y, Koumenis C, Fan Y.    c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest 126(5): 1801-14, May 2016.

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