Publications

1. Stanger BZ, Wahl GM. Cancer as a Disease of Development Gone Awry. Annu Rev Pathol. 2023 Oct 13. doi: 10.1146/annurev-pathmechdis-031621-025610. Epub ahead of print. PMID: 37832945.

2. Pitarresi JR, Stanger BZ. Cellular Origins and Lineage Plasticity in Cancer. Cold Spring Harb Perspect Med. 2023 Aug 21:a041389. doi: 10.1101/cshperspect.a041389. Epub ahead of print. PMID: 37604590.

3. Kemp SB, Cheng N, Markosyan N, Sor R, Kim IK, Hallin J, Shoush J, Quinones L, Brown NV, Bassett JB, Joshi N, Yuan S, Smith M, Vostrejs WP, Perez-Vale KZ, Kahn B, Mo F, Donahue TR, Radu CG, Clendenin C, Christensen JG, Vonderheide RH, Stanger BZ. Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer. Cancer Discov. 2023 Feb 6;13(2):298-311. doi: 10.1158/2159-8290.CD-22-1066. PMID: 36472553; PMCID: PMC9900321.

4. Sela Y, Li J, Maheswaran S, Norgard R, Yuan S, Hubbi M, Doepner M, Xu JP, Ho ES, Mesaros C, Sheehan C, Croley G, Muir A, Blair IA, Shalem O, Dang CV, Stanger BZ. Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer. Cancer Res. 2022 May 16;82(10):1890-1908. doi: 10.1158/0008-5472.CAN-22-0431. PMID: 35315913; PMCID: PMC9117449.

5. Maddipati R, Norgard RJ, Baslan T, Rathi KS, Zhang A, Saeid A, Higashihara T, Wu F, Kumar A, Annamalai V, Bhattacharya S, Raman P, Adkisson CA, Pitarresi JR, Wengyn MD, Yamazoe T, Li J, Balli D, LaRiviere MJ, Ngo TC, Folkert IW, Millstein ID, Bermeo J, Carpenter EL, McAuliffe JC, Oktay MH, Brekken RA, Lowe SW, Iacobuzio-Donahue CA, Notta F, Stanger BZ. MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma. Cancer Discov. 2022 Feb;12(2):542-561. doi: 10.1158/2159-8290.CD-20-1826. Epub 2021 Sep 22. PMID: 34551968; PMCID: PMC8831468.

6. Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ. Calcium signaling induces a partial EMT. EMBO Rep. 2021 Sep 6;22(9):e51872. doi: 10.15252/embr.202051872. Epub 2021 Jul 29. PMID: 34324787; PMCID: PMC8419705.

7. Sela Y, Li J, Kuri P, Merrell AJ, Li N, Lengner C, Rompolas P, Stanger BZ. Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation. Elife. 2021 Feb 23;10:e63270. doi: 10.7554/eLife.63270. PMID: 33620315; PMCID: PMC7929558.

8. Merrell AJ, Peng T, Li J, Sun K, Li B, Katsuda T, Grompe M, Tan K, Stanger BZ. Dynamic Transcriptional and Epigenetic Changes Drive Cellular Plasticity in the Liver. Hepatology. 2021 Jul;74(1):444-457. doi: 10.1002/hep.31704. Epub 2021 Jul 12. PMID: 33423324; PMCID: PMC8271088.

9. Kahn BM, Lucas A, Alur RG, Wengyn MD, Schwartz GW, Li J, Sun K, Maurer HC, Olive KP, Faryabi RB, Stanger BZ. The vascular landscape of human cancer. J Clin Invest. 2021 Jan 19;131(2):e136655. doi: 10.1172/JCI136655. PMID: 33258803; PMCID: PMC7810485.

10. Li J, Yuan S, Norgard RJ, Yan F, Sun YH, Kim IK, Merrell AJ, Sela Y, Jiang Y, Bhanu NV, Garcia BA, Vonderheide RH, Blanco A, Stanger BZ. Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer. Cancer Discov. 2021 Mar;11(3):736-753. doi: 10.1158/2159-8290.CD-20-0519. Epub 2020 Nov 6. PMID: 33158848; PMCID: PMC7933070.

11. Yuan S, Natesan R, Sanchez-Rivera FJ, Li J, Bhanu NV, Yamazoe T, Lin JH, Merrell AJ, Sela Y, Thomas SK, Jiang Y, Plesset JB, Miller EM, Shi J, Garcia BA, Lowe SW, Asangani IA, Stanger BZ. Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression. Cancer Discov. 2020 Jun;10(6):854-871. doi: 10.1158/2159-8290.CD-19-1299. Epub 2020 Mar 18. PMID: 32188706; PMCID: PMC7269857.

12. Li J, Yuan S, Norgard RJ, Yan F, Yamazoe T, Blanco A, Stanger BZ. Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer. Cancer Immunol Res. 2020 Mar;8(3):282-291. doi: 10.1158/2326-6066.CIR-19-0661. Epub 2019 Dec 23. PMID: 31871120; PMCID: PMC7173406.

13. Markosyan N, Li J, Sun YH, Richman LP, Lin JH, Yan F, Quinones L, Sela Y, Yamazoe T, Gordon N, Tobias JW, Byrne KT, Rech AJ, FitzGerald GA, Stanger BZ, Vonderheide RH. Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2). J Clin Invest. 2019 Jun 4;129(9):3594-3609. doi: 10.1172/JCI127755. PMID: 31162144; PMCID: PMC6715369.

14. Yuan S, Norgard RJ, Stanger BZ. Cellular Plasticity in Cancer. Cancer Discov. 2019 Jul;9(7):837-851. doi: 10.1158/2159-8290.CD-19-0015. Epub 2019 Apr 16. PMID: 30992279; PMCID: PMC6606363.

15. Li J, Stanger BZ. The tumor as organizer model. Science. 2019 Mar 8;363(6431):1038-1039. doi: 10.1126/science.aau9861. PMID: 30846584.

16. Li J, Byrne KT, Yan F, Yamazoe T, Chen Z, Baslan T, Richman LP, Lin JH, Sun YH, Rech AJ, Balli D, Hay CA, Sela Y, Merrell AJ, Liudahl SM, Gordon N, Norgard RJ, Yuan S, Yu S, Chao T, Ye S, Eisinger-Mathason TSK, Faryabi RB, Tobias JW, Lowe SW, Coussens LM, Wherry EJ, Vonderheide RH, Stanger BZ. Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy. Immunity. 2018 Jul 17;49(1):178-193.e7. doi: 10.1016/j.immuni.2018.06.006. Epub 2018 Jun 26. PMID: 29958801; PMCID: PMC6707727.

17. Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ. EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Dev Cell. 2018 Jun 18;45(6):681-695.e4. doi: 10.1016/j.devcel.2018.05.027. PMID: 29920274; PMCID: PMC6014628.

18. Aiello NM, Brabletz T, Kang Y, Nieto MA, Weinberg RA, Stanger BZ. Upholding a role for EMT in pancreatic cancer metastasis. Nature. 2017 Jul 5;547(7661):E7-E8. doi: 10.1038/nature22963. PMID: 28682339; PMCID: PMC5830071.

19. Balli D, Rech AJ, Stanger BZ, Vonderheide RH. Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer. Clin Cancer Res. 2017 Jun 15;23(12):3129-3138. doi: 10.1158/1078-0432.CCR-16-2128. Epub 2016 Dec 22. PMID: 28007776.

20. Aiello NM, Bajor DL, Norgard RJ, Sahmoud A, Bhagwat N, Pham MN, Cornish TC, Iacobuzio-Donahue CA, Vonderheide RH, Stanger BZ. Metastatic progression is associated with dynamic changes in the local microenvironment. Nat Commun. 2016 Sep 15;7:12819. doi: 10.1038/ncomms12819. PMID: 27628423; PMCID: PMC5027614.

21. Maddipati R, Stanger BZ. Pancreatic Cancer Metastases Harbor Evidence of Polyclonality. Cancer Discov. 2015 Oct;5(10):1086-97. doi: 10.1158/2159-8290.CD-15-0120. Epub 2015 Jul 24. PMID: 26209539; PMCID: PMC4657730.

22. Penzo-Méndez AI, Chen YJ, Li J, Witze ES, Stanger BZ. Spontaneous Cell Competition in Immortalized Mammalian Cell Lines. PLoS One. 2015 Jul 22;10(7):e0132437. doi: 10.1371/journal.pone.0132437. PMID: 26200654; PMCID: PMC4511643.

23. Yanger K, Knigin D, Zong Y, Maggs L, Gu G, Akiyama H, Pikarsky E, Stanger BZ. Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. Cell Stem Cell. 2014 Sep 4;15(3):340-349. doi: 10.1016/j.stem.2014.06.003. Epub 2014 Aug 14. PMID: 25130492; PMCID: PMC4505916.

24. Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Iacobuzio-Donahue C, Olive KP, Stanger BZ. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 2014 Jun 16;25(6):735-47. doi: 10.1016/j.ccr.2014.04.021. Epub 2014 May 22. PMID: 24856585; PMCID: PMC4096698.

25. Rhim AD, Thege FI, Santana SM, Lannin TB, Saha TN, Tsai S, Maggs LR, Kochman ML, Ginsberg GG, Lieb JG, Chandrasekhara V, Drebin JA, Ahmad N, Yang YX, Kirby BJ, Stanger BZ. Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions. Gastroenterology. 2014 Mar;146(3):647-51. doi: 10.1053/j.gastro.2013.12.007. Epub 2013 Dec 13. PMID: 24333829; PMCID: PMC4514438.

26. Yanger K, Zong Y, Maggs LR, Shapira SN, Maddipati R, Aiello NM, Thung SN, Wells RG, Greenbaum LE, Stanger BZ. Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev. 2013 Apr 1;27(7):719-24. doi: 10.1101/gad.207803.112. Epub 2013 Mar 21. Erratum in: Genes Dev. 2013 Jul 1;27(13):1537. PMID: 23520387; PMCID: PMC3639413.

27. Gao T, Zhou D, Yang C, Singh T, Penzo-Méndez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ. Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology. 2013 Jun;144(7):1543-53, 1553.e1. doi: 10.1053/j.gastro.2013.02.037. Epub 2013 Feb 27. PMID: 23454691; PMCID: PMC3665616.

28. Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ. EMT and dissemination precede pancreatic tumor formation. Cell. 2012 Jan 20;148(1-2):349-61. doi: 10.1016/j.cell.2011.11.025. PMID: 22265420; PMCID: PMC3266542.