Center for
Global Health

International Scholar

Languages: English (fluent), Thai (native), Japanese (beginner)

Bio statement

Dr. Objoon Trachoo is currently a Clinical Associate Professor and Chair of Medical Genetics at VinUniversity in Hanoi, Vietnam. He is responsible for overseeing Medical Genetics and Genomics at VinUniversity and all its teaching hospitals. With 15 years of experience in delivering clinical genetics services to patients and families affected by or at risk of genetic disorders, Dr. Trachoo has a special interest in rare and undiagnosed conditions. His passion is to develop robust medical genetics and genomics programs in Vietnam, Thailand, and other Southeast Asian countries, as well as to implement genomic technology to improve healthcare outcomes.

Recent global health projects

1. Genomic etiology of early-onset epileptic encephalopathy: I am responsible for the clinical genetics evaluation and interpretation of genomic data for children with this condition. Infantile-onset epilepsy can lead to subsequent brain damage and disability. By working closely with pediatric neurologists, we can detect genes contributing to epilepsy, which facilitates precise medical management and clinical outcome prediction. This work plays a pivotal role in genetic counseling, including assessing recurrence risk in parental subsequent pregnancies and planning reproductive options.

2. Molecular diagnosis of aortopathy: Thoracic aortic dissection is a life-threatening condition that can be prevented with early detection through medication and surgical intervention. I have been providing clinical genetics services for patients presenting with aortic dilatation, aneurysm, and dissection by age 60. Several genetic etiologies have been identified, including Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome (vascular type), arterial tortuosity syndrome, and non-syndromic familial thoracic aortic aneurysm/dissection (FTAAD). Following the detection of genetic variants causing these conditions, precise management programs, including the prevention of other asymptomatic family members, have been implemented.

Selected publications

Suphatsathienkul P, Sakpichaisakul K, Wechapinan T, Trachoo O, Virawan S, Wanitphakdeedecha R. Successful Treatment of Schwartz-Jampel Syndrome with Botulinum Toxin Type A. Dermatol Ther (Heidelb). 2024;14:545-56.

Sakpichaisakul K, Boonkrongsak R, Lertbutsayanukul P, Iemwimangsa N, Klumsathien S, Panthan S, Trachoo O*. Epileptic spasms related to neuronal differentiation factor 2 (NEUROD2) mutation respond to combined vigabatrin and high-dose prednisolone therapy. BMC Neurol 2022; 22: 461.

Trachoo O*, Yingchoncharoen T, Ngernsritrakul T, Iemwimangsa N, Panthan B, Klumsathian S, Srisukh S, Mukdadilok A, Phusanti S, Charoenyingwattana A, Chareonsirisuthigul T, Chantratita W, Tangcharoen T. Genomic findings of hypertrophic and dilated cardiomyopathy in a Thai clinical genetics service. PLoS One 2022; 17: e0267770.

Duangchan T, Tawonsawatruk T, Angsanuntsukh C, Trachoo O, Hongeng S, Kitiyanant N, Supokawej A. Amelioration of osteogenesis in iPSC-derived mesenchymal stem cells from osteogenesis imperfecta patients by endoplasmic reticulum stress inhibitor. Life Sci 2021; 278: 119628.

Satirapod C, Sukprasert M, Panthan B, Charoenyingwattana A, Chitayanan P, Chantratita W, Choktanasiri W, Trachoo O*, Hongeng S. Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: a retrospective review from a single center. PLoS One 2019; 14: e0225457.

Sakpichaisakul K, Saengow VE, Suwanpratheep P, Rongnoparat K, Panthan B, Trachoo O*. Novel PANK2 mutation discovered among South East Asian children living in Thailand affected with pantothenate kinase associated neurodegeneration. J Clin Neurosci 2019; 66: 187-90.

Kantaputra PN, Smith LJ, Casal ML, Kuptanon C, Chang YC, Nampoothiri S, Paiyarom A, Veerasakukwong T, Trachoo O, Ketudat Cairns JR, Chinadet W, Tanpaiboon P. Oral manifestations in patients and dogs with mucopolysaccharidosis type VII. Am J Med Genet A 2019; 179: 486-93

Last Updated: 01 August 2024