Sex chromosome-encoded protein homologs in sex bias of human cancers
Sex differences are evident in tumor incidence and mortality throughout the world, across a wide age range and many different cancers. One of the major keys to sex-biased differences lies in the sex chromosomes. Our lab focuses on the functional similarities and differences of sex chromosome-encoded RNA helicases in sex bias of human cancers!
We use biochemical, cellular, high-throughput sequencing, and single-molecule FRET microscopes (collaboration with the Goldman Lab https://www.med.upenn.edu/goldmanlab/).
Check out our first discovery on DDX3X and DDX3Y in Mol. Cell https://www.cell.com/molecular-cell/pdfExtended/S1097-2765(22)00385-9