X-Y Paired Homologous Proteins and Cancer Vulnerabilities
Our lab is leading the molecular-level efforts to explore X-Y paired homologous proteins as a novel axis in cancer biology. Using one of the X-Y paired homologs as an example, we recently discovered that the X-linked DDX3X and its Y-linked homolog DDX3Y, while structurally similar, exhibit distinct biochemical activities in RNA helicase function and translation regulation. By uncovering these molecular differences, we have developed innovative approaches to selectively target DDX3X and DDX3Y, providing the first strategies for sex-specific precision therapies. We are now extending this research to systematically explore additional X-Y homologous protein pairs, uncovering a previously untapped landscape of biochemical diversity and therapeutic potential.
Key Highlights:
- Our lab pioneers in studying functional divergence and overlap of X-Y paired homologous proteins in cancer using biochemistry, biophysics, and molecular biology approaches.
- Demonstrated distinct helicase activity and condensation-mediated translational regulation of DDX3X and DDX3Y.
- Developed novel methods to selectively target DDX3X and DDX3Y for cancer therapy.
- Expanding research to other sex chromosome homologous protein pairs to uncover novel biology and therapeutic opportunities.
- Unique "understanding to treating" paradigm.
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