PKC-Regulated Transcriptional Networks in Prostate Cancer

  • Roles of DAG-regulated PKCs in the initiation and progression of prostate cancer.
  • DAG effectors as regulators of tumorigenic and metastatic transcriptional networks 
  • PKC isozymes as regulators of EMT transcription factors in aggressive prostate cancer.
  • Cooperation between PKCs and loss of tumor suppressor genes in the development of prostate cancer using genetically-engineered mouse models.