Rac-GEFs in Invasion and Metastasis
- Identification of Rac Guanine-nucleotide Exchange Factors (Rac-GEFs) as effectors of Receptor Tyrosine Kinases (RTKs) and oncogenic KRAS in lung adenocarcinoma.
- Development of mouse models to establish the role of Rac-GEFs in lung tumorigenesis and metastasis.
- Expression of Rac-GEFs in human lung primary tumors, circulating tumor cells (CTCs) and malignant pleural effusions.