Small GTPases in Cancer Cell Motility and Cell-Cell Communication
- Role of Rac1 and Rac-GEFs in receptor-mediated formation of actin-rich membrane projections.
- Characterization of receptor adaptors and effectors required for the activation of Rac-GEFs and their association with the formation of actin-rich ruffles.
- Determination of the roles of Rac-GEF/Rac1 signaling in membrane ruffle dynamics.
- Involvement of Rho GTPases, their effectors and regulators in the formation of tunneling nanotubes and cell-cell communication.