Selected Publications

All PubMed Publications

https://pubmed.ncbi.nlm.nih.gov/?term=Kazanietz&sort=date

Links to Select Publications

Cooke M, Zhang S, Cornejo Maciel F, Kazanietz MG. Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis. J. Biol. Chem. 2023 Aug;299(8):104983. https://www.sciencedirect.com/science/article/pii/S0021925823020112?via%3Dihub

Cooke M, Kazanietz MG. Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity. Sci Signal. 2022 Apr 12;15(729):eabo0264. https://www.science.org/doi/10.1126/scisignal.abo0264?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Kazanietz MG, Cooke M, Garcia-Mata R. Nonredundant Rac-GEF control of actin cytoskeleton reorganization. Trends Cell Biol. 2022 Oct;32(10):815-818. https://www.sciencedirect.com/science/article/pii/S0962892422001428?via%3Dihub

Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh SJ, Reiterer V, Parizadeh A, Felder E, Kahlhofer JC, Teis D, Kazanietz MG, Geley S, Eriksson L, Roca-Cusachs P, Farhan H. Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1. EMBO J. 2022 Sep 15;41(18):e110596. https://doi.org/10.15252/embj.2022110596

Liu X, Verma A, Garcia G Jr, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS. Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2113401118. https://doi.org/10.1073/pnas.2113401118

Cooke M, Kreider-Letterman G, Baker MJ, Zhang S, Sullivan NT, Eruslanov E, Abba MC, Goicoechea SM, García-Mata R, Kazanietz MG. FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma. Cell Rep. 2021 Nov 2;37(5):109905. https://doi.org/10.1016/j.celrep.2021.109905

Garg R, Cooke M, Benavides F, Abba MC, Cicchini M, Feldser DM, Kazanietz MG. PKCε Is Required for KRAS-Driven Lung Tumorigenesis. Cancer Res. 2020 Dec 1;80(23):5166-5173.  https://doi.org/10.1158/0008-5472.CAN-20-1300

Baker MJ, Cooke M, Kreider-Letterman G, Garcia-Mata R, Janmey PA, Kazanietz MG. Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis. J Biol Chem. 2020 Oct 2;295(40):13698-13710. https://www.jbc.org/article/S0021-9258(17)49822-X/fulltext

Garg R, Blando JM, Perez CJ, Lal P, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG. COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer. Oncogene. 2018 Aug;37(34):4735-4749. https://www.nature.com/articles/s41388-018-0318-9

Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG. Characterization of AJH-836, a diacylglycerol-lactone with selectivity for novel PKC isozymes. J Biol Chem. 2018 Jun 1;293(22):8330-8341. https://www.jbc.org/article/S0021-9258(20)39081-5/fulltext

Kazanietz MG, Caloca MJ. The Rac GTPase in Cancer: From Old Concepts to New Paradigms. Cancer Res. 2017 Oct 15;77(20):5445-5451. https://aacrjournals.org/cancerres/article/77/20/5445/622765/The-Rac-GTPase-in-Cancer-From-Old-Concepts-to-New

Garg R, Blando JM, Perez CJ, Abba MC, Benavides F, Kazanietz MG. Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway. Cell Rep. 2017 Apr 11;19(2):375-388. https://doi.org/10.1016/j.celrep.2017.03.042

Baker MJ, Cooke M, Kazanietz MG. Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis. Cancer Cell. 2017 Feb 13;31(2):167-169. https://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30008-9

Lopez-Haber C, Barrio-Real L, Casado-Medrano V, Kazanietz MG. Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α. Mol Cell Biol. 2016 Jul 14;36(15):2011-26. https://doi.org/10.1128/MCB.00180-16

Gutierrez-Uzquiza A, Lopez-Haber C, Jernigan DL, Fatatis A, Kazanietz MG. PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis. Mol Cancer Res. 2015 Sep;13(9):1336-46. https://doi.org/10.1158/1541-7786.MCR-15-0111

Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, Kazanietz MG. Transcriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins. J Biol Chem. 2014 Jul 11;289(28):19823-38. https://doi.org/10.1074/jbc.M114.548446

Gutierrez-Uzquiza A, Colon-Gonzalez F, Leonard TA, Canagarajah BJ, Wang H, Mayer BJ, Hurley JH, Kazanietz MG. Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol. Nat Commun. 2013;4:1849. https://www.nature.com/articles/ncomms2834

Barrio-Real L, Kazanietz MG. Rho GEFs and cancer: linking gene expression and metastatic dissemination. Sci Signal. 2012 Oct 2;5(244):pe43. https://www.science.org/doi/10.1126/scisignal.2003543

Riccomagno MM, Hurtado A, Wang H, Macopson JG, Griner EM, Betz A, Brose N, Kazanietz MG, Kolodkin AL. The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell. 2012 Jun 22;149(7):1594-606. https://doi.org/10.1016/j.cell.2012.05.018

Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG. Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. J Biol Chem. 2011 Apr 1;286(13):11254-64. https://doi.org/10.1074/jbc.M110.194332

Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell. 2010 Dec 22;40(6):877-92. https://doi.org/10.1016/j.molcel.2010.11.029

Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer. 2007 Apr;7(4):281-94. https://www.nature.com/articles/nrc2110

Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG. Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 2006 May 17;25(10):2062-74. https://doi.org/10.1038/sj.emboj.7601098

Leskow FC, Holloway BA, Wang H, Mullins MC, Kazanietz MG. The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5373-8. https://doi.org/10.1073/pnas.0508585103

Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH. Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell. 2004 Oct 29;119(3):407-18. https://doi.org/10.1016/j.cell.2004.10.012

Caloca MJ, Garcia-Bermejo ML, Blumberg PM, Lewin NE, Kremmer E, Mischak H, Wang S, Nacro K, Bienfait B, Marquez VE, Kazanietz MG. beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11854-9. https://doi.org/10.1073/pnas.96.21.11854

Zhang G, Kazanietz MG, Blumberg PM, Hurley JH. Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell. 1995 Jun 16;81(6):917-24. https://www.cell.com/cell/pdf/0092-8674(95)90011-X.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2F009286749590011X%3Fshowall%3Dtrue