Miner Lab Papers

Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Chauvin SD, Ando S, Holley JA, Sugie A, Zhao FR, Poddar S, Kato R, Miner CA, Nitta Y, Krishnamurthy SR, Saito R, Ning Y., Hatano Y, Kitahara S, Koide S, Stinson WA, Fu J, Surve N, Kumble L, Polishchuk O, Andhey PS, Chiang C, Liu G, Colombeau L, Rodriquez R, Manel N, Kakita A, Artyomov MN, Schulz DC, Coates PT, Roberson EDO, Belkaid Y, Greenberg RA, Cherry S, Gack MU, Hardy T, Onodera O, Kato T, Miner JJ. Nature Communications. 2024 Jun.
Regulation of cGAS and STING signaling during inflammation and infection. Chauvin SD, Stinson WA, Platt DJ, Poddar S, Miner JJ. Journal of Biological Chemistry. 2023 May.
A path towards personalized medicine for autoinflammatory and related diseases. Miner JJ, Fitzgerald KA. Nature Reviews Rheumatolology. 2023 Mar.
Liver Pathology in Retinal Vasculopathy with Cerebral Leukoencephalopathy and Systemic Manifestations (RVCL-S): Vasculopathic Disease Beyond Nodular Regenerative Hyperplasia (NRH). Khonde P, Chatterjee D, Bogacki M, Liszewski MK, Ford AL, Miner JJ, Atkinson JP, Brunt EM. Human Pathology. 2023 Mar.
The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice. Stinson WA, Miner CA, Zhao FR, Lundgren AJ, Poddar S, Miner JJ. JCI Insight. 2022 Sep.
Dynamic Changes in the Nasal Microbiome Associated With Disease Activity in Patients With Granulomatosis With Polyangiitis. Rhee RL, Lu J, Bittinger K, Lee JJ, Mattei LM, Sreih AG, Chou S, Miner JJ, Cohen NA, Kelly BJ, Lee H, Grayson PC, Collman RG, Merkel PA. Arthritis and Rheumatology. 2021 Sep.
Transferrable protection by gut microbes against STING-associated lung disease. Platt DJ, Lawrence D, Rodgers R, Schriefer L, Qian W, Miner CA, Menos AM, Kennedy EA, Peterson ST, Stinson WA, Baldridge MT, Miner JJ. Cell Reports. 2021 May 11.
Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid. Walker FC, Hassan E, Peterson ST, Rodgers R, Schriefer LA, Thompson CE, Li Y, Kalugotla G, Blum-Johnston C, Lawrence D, McCune BT, Graziano VR, Lushniak L, Lee S, Roth AN, Karst SM, Nice TJ, Miner JJ, Wilen CB, Baldridge MT. PLoS Pathogens. 2021 Mar.
HSV-1 and Zika virus but not SARS-CoV-2 replicate in the human cornea and are restricted by corneal type III interferon. Miner JJ, Platt DJ, Ghaznavi CM, Chandra P, Santeford A, Menos AM, Dong Z, Wang ER, Qian W, Karozichian ES, Philips JA, Apte RS. Cell Reports. 2020. Nov 3.
Digital spatial profiling of coronary plaques from persons living with HIV reveals high levels of STING and CD163 in macrophage-enriched regions. Wanjalla CN, Guo L, Fuller DT, Mashayekhi M, Bailin S, Gabriel CL, Temu T, Gong J, Liang Y, Virmani R, Finn AV, Kalams SA, Mallal SA, Miner JJ, Beckman JA, Koethe JR. BioRxiv. 2020. Jul 29.
Heterozygous RELA mutations cause early-onset systemic lupus erythematosus by hijacking the NF-κB pathway towards transcriptional activation of type-I Interferon genes. Barnabei L, Castela M, Jeremiah N, Stolzenberg M-C, Chentout L, Jacques S, Bouafia A, magerus-Chatinet A, Moncan M, Mirshahvalad S, Pellé O, Bondet V, Duffy D, Parisot M, Bras M, Uggenti C, Salomon R, Bodemer C, Rabant M, Cavazzana M, Miner JJ, Belot A, Hié M, Picard C, Bader-Meunier B, Kracker S, Rieux-Laucat F. BioRxiv. 2020. Apr 28.
Lesion evolution and neurodegeneration in RVCL-S: a monogenic microvasculopathy. Ford AL, Chin V, Fellah S, Binkley MM, Bodin A, Balasetti V, Taiwo Y, Kang P, Lin D, Jen J, Grand G, Bogacki M, Liszewski K, Hourcade D, Chen Y, Hassenstab J, Lee JM, An H, Miner JJ, Atkinson JP. Neurology. 2020. Sep 4.
Immunopathology of Zika virus infection. Platt DJ, Miner JJ. Advances in Virus Research. 2020;107:223-246. Epub 2020 Jul 7.
STING gain-of-function disrupts lymph node organogenesis and innate lymphoid cell development in mice. Bennion BG, Croft CA, Ai TL, Qian W, Menos AM, Miner CA, Fremond ML, Doisne JM, Andhey PS, Platt DJ, Bando JK, Wang ER, Luksch H, Molina TJ, Robison EDO, Artyomov MN, Rosen-Wolff A, Colonna M, Rieux-Laucat F, Di Santo JP, Neven B, Miner JJ. Cell Reports. 2020. Jun. 16;31(11):107771.
TBK1 and IKKe act redundantly to mediate STING-induced NF-kB responses in myeloid cells. Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D’Silva DB, Moghaddas F, Tailler M, Lawlor KE, Zhan Y, Burns CJ, Wicks IP, Miner JJ, Kile BT, Masters SL, De Nardo D. Cell Reports. 2020 Apr 7;31(1):107492.
Barrier-to-Autointegration Factor 1 protects against a basal cGAS-STING response. Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum AK, Zhang R, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS. mBio. 2020 Mar 10; 11(2). pii: e00136-20.
Protective and Pathogenic Effects of Interferon Signaling During Pregnancy. Casazza, RL, Lazear, HJ, Miner JJ. Viral Immunology. 2020. Jan/Feb; 33(1):3-11.
A human STAT1 gain-of-function mutation impairs CD8⁺ T cell responses against gammaherpesvirus-68. Qian W, Miner CA, Ingle H, Platt DJ, Baldridge MT, Miner JJ. Journal of Virology. 2019 Sep 12;93(19). pii: e00307-19.
Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Ingle H, Lee S, Ai T, Orvedahl A, Rodgers R, Zhao G, Sullender M, Peterson ST, Locke M, Liu TC, Yokoyama CC, Sharp B, Schultz-Cherry S, Miner JJ, Baldridge MT. Nature Microbiology. 2019 Jul;4(7):1120-1128. PMID:30936486
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N. Journal of Experimental Medicine. 2019 Apr 1;216(4):867-883. doi: 10.1084/jem.20182192.
STING-associated lung disease in mice relies on T cells but not type I interferon. Luksch H, Stinson WA, Platt DJ, Qian W, Kalugotla G, Miner CA, Bennion BG, Gerbaulet A, Rösen-Wolff A, Miner JJ. Journal of Allergy and Clinical Immunology. 2019 Jul; 144(1):154-266.e8.
A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice. Bennion BG, Ingle H, Ai TL, Miner CA, Platt DJ, Smith AM, Baldridge MT, Miner JJ. Journal of Virology. 2019 Feb 5;93(4). pii: e01806-18.
Tofacitinib for refractory uveitis and scleritis. Paley MA, Karacal H, Rao PK, Margolis TP, Miner JJ. American Journal of Ophthalmology Case Reports. 2018 Dec 4;13:53-55. doi: 10.1016/j.ajoc.2018.12.001. eCollection 2019 Mar.
HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection. MacDuff DA, Baldridge MT, Qaqish AM, Nice TJ, Darbandi AD, Hartley VL, Peterson ST, Miner JJ, Iwai K, Virgin HW. Journal of Virology. 2018 Nov 12;92(23). pii: e01368-18. doi: 10.1128/JVI.01368-18. Print 2018 Dec 1. PMID:30209176
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling. Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK. Proceedings of the National Academy of Sciences U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30.PMID:30061387
Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice. Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ. Science Translational Medicine. 2018 Jan 31;10(426). pii: eaao7090. doi: 10.1126/scitranslmed.aao7090. PMID:29386359
Editorial: Lessons Learned From Chikungunya in the Americas. Miner JJ, Lenschow DJ. Arthritis and Rheumatology. 2018 Apr;70(4):477-479. doi: 10.1002/art.40421. Epub 2018 Mar 13. No abstract available. PMID:29361204
Consequences of congenital Zika virus infection. Platt DJ, Miner JJ. Current Opinion in Virology. 2017 Dec;27:1-7. doi: 10.1016/j.coviro.2017.09.005. Epub 2017 Nov 6. Review. PMID:29080429
STING-associated vasculopathy develops independently of IRF3 in mice. Warner JD, Irizarry-Caro RA, Bennion BG, Ai TL, Smith AM, Miner CA, Sakai T, Gonugunta VK, Wu J, Platt DJ, Yan N, Miner JJ. Journal of Experimental Medicine. 2017 Nov 6;214(11):3279-3292. doi: 10.1084/jem.20171351. Epub 2017 Sep 26. PMID:28951494
Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero. Jagger BW, Miner JJ, Cao B, Arora N, Smith AM, Kovacs A, Mysorekar IU, Coyne CB, Diamond MS. Cell Host & Microbe. 2017 Sep 13;22(3):366-376.e3. doi: 10.1016/j.chom.2017.08.012. PMID:28910635
Congenital Zika virus infection: More than just microcephaly. Miner JJ. Science Translational Medicine. 2017 Jun 7;9(393). pii: eaan8195. doi: 10.1126/scitranslmed.aan8195. PMID: 28592568
Dengue Antibodies, then Zika: A Fatal Sequence in Mice. Miner JJ, Diamond MS. Immunity. 2017 May 16;46(5):771-773. doi: 10.1016/j.immuni.2017.04.023. PMID:28514683
Defeating Zika. Miner JJ.Science Translational Medicine. 2017 Apr 26;9(387). pii: eaan2785. doi: 10.1126/scitranslmed.aan2785. PMID:28446685
Gamete fusion gone viral. Miner JJ.Science Translational Medicine. 2017 Mar 15;9(381). pii: eaam9866. doi: 10.1126/scitranslmed.aam9866. PMID:28298425
Zika Virus Pathogenesis and Tissue Tropism. Miner JJ, Diamond MS. Cell Host & Microbe. 2017 Feb 8;21(2):134-142. doi: 10.1016/j.chom.2017.01.004. Review. PMID:28182948
Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen. Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S. Lancet Infectious Diseases. 2017 Apr;17(4):e107-e117. doi: 10.1016/S1473-3099(16)30385-1. Epub 2017 Feb 1. Review. PMID:28159534
Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis. Miner JJ, Cook LE, Hong JP, Smith AM, Richner JM, Shimak RM, Young AR, Monte K, Poddar S, Crowe JE Jr, Lenschow DJ, Diamond MS. Science Translational Medicine. 2017 Feb 1;9(375). pii: eaah3438. doi: 10.1126/scitranslmed.aah3438. PMID: 28148840

Miner Lab Papers

Regulation of cGAS and STING signaling during inflammation and infection. Chauvin SD, Stinson WA, Platt DJ, Poddar S, Miner JJ. Journal of Biological Chemistry. 2023 May.

A path towards personalized medicine for autoinflammatory and related diseases. Miner JJ, Fitzgerald KA. Nature Reviews Rheumatolology. 2023 Mar.

Liver Pathology in Retinal Vasculopathy with Cerebral Leukoencephalopathy and Systemic Manifestations (RVCL-S): Vasculopathic Disease Beyond Nodular Regenerative Hyperplasia (NRH). Khonde P, Chatterjee D, Bogacki M, Liszewski MK, Ford AL, Miner JJ, Atkinson JP, Brunt EM. Human Pathology. 2023 Mar.

The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice. Stinson WA, Miner CA, Zhao FR, Lundgren AJ, Poddar S, Miner JJ. JCI Insight. 2022 Sep.

Dynamic Changes in the Nasal Microbiome Associated With Disease Activity in Patients With Granulomatosis With Polyangiitis. Rhee RL, Lu J, Bittinger K, Lee JJ, Mattei LM, Sreih AG, Chou S, Miner JJ, Cohen NA, Kelly BJ, Lee H, Grayson PC, Collman RG, Merkel PA. Arthritis and Rheumatology. 2021 Sep.

Transferrable protection by gut microbes against STING-associated lung disease. Platt DJ, Lawrence D, Rodgers R, Schriefer L, Qian W, Miner CA, Menos AM, Kennedy EA, Peterson ST, Stinson WA, Baldridge MT, Miner JJ. Cell Reports. 2021 May 11.

HSV-1 and Zika virus but not SARS-CoV-2 replicate in the human cornea and are restricted by corneal type III interferon. Miner JJ, Platt DJ, Ghaznavi CM, Chandra P, Santeford A, Menos AM, Dong Z, Wang ER, Qian W, Karozichian ES, Philips JA, Apte RS. Cell Reports. 2020. Nov 3.

Immunopathology of Zika virus infection. Platt DJ, Miner JJ. Advances in Virus Research. 2020;107:223-246. Epub 2020 Jul 7.

Barrier-to-Autointegration Factor 1 protects against a basal cGAS-STING response. Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum AK, Zhang R, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS. mBio. 2020 Mar 10; 11(2). pii: e00136-20.

Protective and Pathogenic Effects of Interferon Signaling During Pregnancy. Casazza, RL, Lazear, HJ, Miner JJ. Viral Immunology. 2020. Jan/Feb; 33(1):3-11.

A human STAT1 gain-of-function mutation impairs CD8+ T cell responses against gammaherpesvirus-68. Qian W, Miner CA, Ingle H, Platt DJ, Baldridge MT, Miner JJ. Journal of Virology. 2019 Sep 12;93(19). pii: e00307-19.

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N. Journal of Experimental Medicine. 2019 Apr 1;216(4):867-883. doi: 10.1084/jem.20182192.

STING-associated lung disease in mice relies on T cells but not type I interferon. Luksch H, Stinson WA, Platt DJ, Qian W, Kalugotla G, Miner CA, Bennion BG, Gerbaulet A, Rösen-Wolff A, Miner JJ. Journal of Allergy and Clinical Immunology. 2019 Jul; 144(1):154-266.e8.

A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice. Bennion BG, Ingle H, Ai TL, Miner CA, Platt DJ, Smith AM, Baldridge MT, Miner JJ. Journal of Virology. 2019 Feb 5;93(4). pii: e01806-18.

Tofacitinib for refractory uveitis and scleritis. Paley MA, Karacal H, Rao PK, Margolis TP, Miner JJ. American Journal of Ophthalmology Case Reports. 2018 Dec 4;13:53-55. doi: 10.1016/j.ajoc.2018.12.001. eCollection 2019 Mar.

Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice. Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ. Science Translational Medicine. 2018 Jan 31;10(426). pii: eaao7090. doi: 10.1126/scitranslmed.aao7090. PMID:29386359

Editorial: Lessons Learned From Chikungunya in the Americas. Miner JJ, Lenschow DJ. Arthritis and Rheumatology. 2018 Apr;70(4):477-479. doi: 10.1002/art.40421. Epub 2018 Mar 13. No abstract available. PMID:29361204

Consequences of congenital Zika virus infection. Platt DJ, Miner JJ. Current Opinion in Virology. 2017 Dec;27:1-7. doi: 10.1016/j.coviro.2017.09.005. Epub 2017 Nov 6. Review. PMID:29080429

Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero. Jagger BW, Miner JJ, Cao B, Arora N, Smith AM, Kovacs A, Mysorekar IU, Coyne CB, Diamond MS. Cell Host & Microbe. 2017 Sep 13;22(3):366-376.e3. doi: 10.1016/j.chom.2017.08.012. PMID:28910635

Congenital Zika virus infection: More than just microcephaly. Miner JJ. Science Translational Medicine. 2017 Jun 7;9(393). pii: eaan8195. doi: 10.1126/scitranslmed.aan8195. PMID: 28592568

Dengue Antibodies, then Zika: A Fatal Sequence in Mice. Miner JJ, Diamond MS. Immunity. 2017 May 16;46(5):771-773. doi: 10.1016/j.immuni.2017.04.023. PMID:28514683

Defeating Zika. Miner JJ.Science Translational Medicine. 2017 Apr 26;9(387). pii: eaan2785. doi: 10.1126/scitranslmed.aan2785. PMID:28446685

Gamete fusion gone viral. Miner JJ.Science Translational Medicine. 2017 Mar 15;9(381). pii: eaam9866. doi: 10.1126/scitranslmed.aam9866. PMID:28298425

Zika Virus Pathogenesis and Tissue Tropism. Miner JJ, Diamond MS. Cell Host & Microbe. 2017 Feb 8;21(2):134-142. doi: 10.1016/j.chom.2017.01.004. Review. PMID:28182948

A human STAT1 gain-of-function mutation impairs CD8⁺ T cell responses against gammaherpesvirus-68. Qian W, Miner CA, Ingle H, Platt DJ, Baldridge MT, Miner JJ. Journal of Virology. 2019 Sep 12;93(19). pii: e00307-19.