Perelman School of Medicine at the University of Pennsylvania

Penn PET Explorer

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    Human Volunteers 1-4 (Left to Right) injected with 15 mCi of FDG. Imgs 1 and 2 are ~90 min post injection and imgs 3 and 4 show early dynamic frames

PennPET Explorer

The PennPET Explorer is an extended field-of-view PET scanner designed for clinical and research uses. Potential uses include total-body dynamic imaging, high throughput patient imaging, and imaging novel PET tracers to better understand cancers. The PennPET Explorer boasts a 250 ps timing resolution, a 4.0 mm spatial resolution, and is built as a modular configuration that can be extended over time depending on applications. 

Advantages of the long axial FOV scanner include

  • Enhance the ability to image in vivo systems simultaneously across multiple organs
  • Reduce administered dose and imaging time
  • Improve image quality and accuracy
  • Dynamically image whole-body bio-distribution studies for drug dosing, along with a variety of other applications not possibly with standard, commercial PET/CT scanners

This work is part of the EXPLORER consortium including the University of California, Davis.

scanner progress
Progression of scanner from detector tile (left) to completed three ring scanner (right) ready for patient imaging



PennPET Explorer papers are in JNM!! 

A.R. Pantel, V. Viswanath, M.E. Daube-Witherspoon, J.G. Dubroff, G. Muehllehner, M.J. Parma, D.A. Pryma, E.K.Schubert, D.A. Mankoff, J.S. Karp. PennPET Explorer: Human imaging on a whole-body imager. J Nucl Med, vol. 61, pp. 144-151, 2020.

J.S. Karp, V. Viswanath, M.J. Geagan, G. Muehllehner, A.R. Pantel, M.J. Parma, A.E. Perkins, J.P. Schmall, M.E. Werner, M.E. Daube-Witherspoon. PennPET Explorer: Design and preliminary performance of a whole-body imager. J Nucl Med, vol. 61, pp. 136-143, 2020.

Detectability paper accepted to PMB!!

Viswanath V, Daube-Witherspoon ME, Karp JS, Surti S. Numerical observer study of lesion detectability for a long axial field-of-view whole-body PET imager using the PennPET Explorer. Physics in Medicine and Biology (Accepted).