Shen Lab at Penn
Welcome to the Laboratory of Li Shen at the Perelman School of Medicine (PSOM) at the University of Pennsylvania. We are affiliated with DBEI and Radiology at PSOM, CIS at SEAS, six graduate groups (GCB|GGEB|NGG at BGS, AMCS at SAS, BioEng|CIS at SEAS), and multiple institutes/centers (IBI, AI2D, ASSET, I3H, ITMAT, IOA, LDI, MINS, PennAITech).
The central theme of our lab is focused on developing and applying informatics, computing and data science methods for discovering actionable knowledge from complex biomedical and health data (e.g., genetics, omics, imaging, biomarker, outcome, EHR, health care). The lab's goal is threefold:
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Advance AI/ML, informatics, and data science by creating novel algorithms for analyzing large-scale, heterogeneous datasets;
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Generate new biological and clinical insights into the phenotypic characteristics and genetic or molecular mechanisms underlying normal or disordered structures and functions, informing the development of diagnostic, therapeutic, and preventive strategies; and
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Improve health and health care through collaborative, multidisciplinary research that informs policy and practice.
Our research spans machine learning, medical image computing, biomedical and health informatics, trustworthy AI, NLP/LLMs, network science, imaging genomics, and multi-omics and systems biology, with applications to Alzheimer’s disease and related dementias (ADRD) and other complex disorders. We focus on developing and applying advanced AI methods to analyze large-scale biobank and health datasets, with the goals of improving understanding, early detection, treatment, and prevention of complex diseases and enhancing human health and health-care delivery. We also pursue emerging frontiers, including generative AI, agentic AI, and trustworthy multimodal AI, to push the boundaries of biomedical research.
We are always excited to work with highly motivated students and scholars with training in biomedical informatics, computer science, AI/ML, mathematics/statistics, engineering, or biology/medicine/healthcare. We may have opportunities for undergraduate and graduate students, and for postdoctoral researchers, subject to funding availability. If you are interested, please email li.shen@pennmedicine.upenn.edu for additional information.