Publications

Structure-Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers

Stehouwer JS, Huang G, Saturnino Guarino D, Debnath ML, Polu A, Geib SJ, Lopresti B, Ikonomovic MD, Mason N, Mach RH, Mathis CA

Journal of Medicinal Chemistry 2025, 68, 6462-6492

Strategic Modulation of Polarity and Viscosity Sensitivity of Bimane Molecular Rotor-Based Fluorophores for Imaging α‐Synuclein

Venkatesh Y, Narayan KB, Baumgart T, Petersson EJ

Journal of The American Chemical Society 2025, 147, 15115-15125.

Replication and reliability of Parkinson’s disease clinical subtypes

Cash TV, Lessov-Schlaggar CN, Foster ER, Myers PS, Jackson JJ, Maiti B, Kotzbauer PT, Perlmutter JS, Campbell MC

Parkinsonism and Related Disorders 2024, 1-8

Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye†

Yarra Venkatesh, Nicholas P. Marotta,  Virginia M.-Y. Lee, and E. James Petersson

Chemical Science 2024, 15 (16), 6053-6063

Development of Pyridothiophene Compounds for PET Imaging of α-Synuclein

Anna Pees, Junchao Tong, Saritha Birudaraju, Yogeshkumar S. Munot, Steven H. Liang, Dinahlee Saturnino Guarino, Robert Mach, Chester A. Mathis, and Neil Vasdev

Chemistry A European Journal 2024, 1-16
 

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy

Ho Young Kim, Wai Kit Chia, Chia-Ju Hsieh, Dinahlee Saturnino Guarino, Thomas J A Graham, Zsofia Lengyel-Zhand, Mark Schneider, Cosette Tomita, Marshall G Lougee, Hee Jong Kim, Vinayak V Pagar, Hsiaoju Lee, Catherine Hou, Benjamin A Garcia, E James Petersson, Jennifer O'Shea, Paul T Kotzbauer, Chester A Mathis, Virginia M-Y Lee, Kelvin C Luk, Robert H Mach

Journal of Medcinal Chemistry 2023, 12185-12202

In Silico Discovery and Subsequent Characterization of Potent 4RTauopathy Positron Emission Tomography Radiotracers

Thomas J. A. Graham, anton Lindberg, Junchao Tong, Jeffrey S. Stehouwer, Neil Vasdev, Robert H. Mach, and Chester A. Mathis

Journal of Medicinal Chemistry 2023, 10628-10638

FRETing about the details: Case studies in the use of a genetically encoded fluorescent amino acid for distance-dependent energy transfer

Michael B. Cory, Chloe M. Jones, Kyle D. Shaffer, Yarra Venkatesh, Sam Giannakoulias, Ryann M. Perez, Marshall G. Lougee, Eshe Hummingbird, Vinayak V. Pagar, Christina M. Hurley, Allen Li, Robert H. Mach, Rahul M. Kohli, E. James Petersson

The Protein Society 2023, 1-19

Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development

Chia-Ju Hsieh, Sam Giannakoulias, E. James Petersson and Robert H. Mach

Pharmaceuticals 2023 16 (317), 1-19

Identifcation of a Putative α‑synuclein Radioligand Using an in silico Similarity Search

Bieneke Janssen, Guilong Tian, Zsofa Lengyel‑Zhand, Chia‑Ju Hsieh, Marshall G. Lougee, Aladdin Riad, Kuiying Xu, Catherine Hou, Chi‑Chang Weng, Brian J. Lopresti, Hee Jong Kim, Vinayak V. Pagar, John J. Ferrie, Benjamin A. Garcia, Chester A. Mathis, Kelvin Luk, E. James Petersson, Robert H. Mach

Molecular Imaging and Biology 2023

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples

Laura N. Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, Chia-Ju Hsieh, Mark E. Schneider Jr., Kimberly J. Edwards, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski and Robert H. Mach

Frontiers in Aging Neuroscience 2021 13 (704041), 1-14

Radiosynthesis, In Vitro and In Vivo Evaluation of [¹⁸F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies

Anton Lindberg, Ashley C. Knight, Daniel Sohn, Laszlo Rakos, Junchao Tong, April Radelet, N. Scott Mason, Jeffrey S. Stehouwer, Brian J. Lopresti, William E. Klunk, Johan Sandell, Alexander Sandberg, Per Hammarström, Samuel Svensson, Chester A. Mathis, and Neil Vasdev

ACS Chemical Neuroscience 2021 12 (4), 596-602

Synthesis and characterization of high affinity fluorogenic a-synuclein probes

Zsofia Lengyel-Zhand, John J. Ferrie, Bieneke Janssen, Chia-Ju Hsieh, Thomas Graham, Kui-ying Xu, Conor M. Haney, Virginia M.-Y. Lee, John Q. Trojanowski, E. James Petersson and Robert H. Mach

ChemComm 2020 56, 3567-3570

Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

Jessica E. Rexach, Damon Polioudakis, Anna Yin, Vivek Swarup, Timothy S. Chang, Tam Nguyen, Arjun Sarkar, Lawrence Chen, Jerry Huang, Li-Chun Lin, William Seeley, John Q. Trojanowski, Dheeraj Malhotra, and Daniel H. Geschwind

Cell Reports 2020 33 (7)

Identification of a nanomolar affinity a-synuclein fibril imaging probe by ultra-high throughput in silico screening

John J. Ferrie, Zsofia Lengyel-Zhand, Bieneke Janssen, Marshall G. Lougee, Sam Giannakoulias, Chia-Ju Hsieh, Vinayak Vishnu Pagar, Chi-Chang Weng, Hong Xu, Thomas J. A. Graham, Virginia M.-Y. Lee, Robert H. Mach and E. James Petersson

Chemical Science 2020 11, 12746-12754