Publications

Machine learning prediction of multiple distinct high-affinity chemotypes for a-synuclein fibrils

Xinning Li, Ryann M. Perez, Zhude Tu, Robert H. Mach, Sam Giannakoulias, E. James Petersson

Chem. Commun. 2026, 62, 2922

Interactions of Neurodegenerative Disease Positron Emission Tomography Imaging Probe Candidates with the C-Terminus of α-Synuclein Fibrils

Shaffer KD, Perez RM, Lougee MG, Pagar VV, Kim HJ, Kim HY, Garcia BA, Mach RH, Petersson EJ

Chembiochem 2025, 26

Discovery of N-(6-Methoxypyridin-3-yl)quinoline-2-amine Derivatives for Imaging Aggregated α-Synuclein in Parkinson’s Disease with Positron Emission Tomography

Haiyang Zhao, Tianyu Huang, Dhruva D. Dhavale, Jennifer Y. O’Shea, Zsofia Lengyel-Zhand, Dinahlee Saturnino Guarino, Jiwei Gu, Xuyi Yue, Ying-Hwey Nai, Hao Jiang, Marshall G. Lougee, Vinayak V. Pagar, Hee Jong Kim, Benjamin A. Garcia, E. James Petersson, Chester A. Mathis, Paul T. Kotzbauer, Joel S. Perlmutter, Robert H. Mach, Zhude Tu

Cells 2025, 14, 1108

Pilot Study of [11C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer

Chia-Ju Hsieh, Dinahlee Saturnino Guarino, Anthony J. Young, Andrew D. Siderowf, Ilya Nasrallah, Alexander Schmitz, Carol Garcia, Ho Young Kim, Erin K. Schubert, Hsiaoju Lee, Joel S. Perlmutter, Robert H. Mach

Cells 2025, 14, 1157

Use of Amplified Lewy Body Dementia Fibrils and Autoradiography to Characterize Binding of Radioligand Tg-1-90B to Alpha-Synuclein Fibrils in Postmortem Brain Tissue

Jennifer Y. O’Shea, Dhruva D. Dhavale, Helen Hwang, Zachary Smith, Thomas J. A. Graham, Robert H. Mach, Paul T. Kotzbauer

Cells 2025, 14, 1477

Genetic code expansion and enzymatic modifications as accessible methods for studying site-specific post-translational modifications of alpha-synuclein and tau

Ibrahim G. Saleh, Marie Shimogawa, Jennifer Ramirez, Bernard Abakah, Yarra Venkatesh, Honey Priya James, Ming-Hao Li, Sarah A. Louie, Marshall G. Lougee, Wai-Kit Chia, Christopher Brue, Richard B. Cooley, Ryan A. Mehl, Tobias Baumgart, Robert H. Mach, David Eliezer, Elizabeth Rhoades, E. James Petersson

Protein Science 2025, 34, 1-15

The development of a PET radiotracer for imaging alpha synuclein aggregates in Parkinson's disease

Gui-Long Tian, Chia-Ju Hsieh, Dinahlee Saturnino Guarino, Thomas J. A. Graham, Zsofia Lengyel-Zhand, Alexander Schmitz, Wai Kit Chia, Anthony J. Young, John-Grey Crosby, Konstantinos Plakas, Tianyu Huang, Hao Jiang, Yanbo Yu, Catherine Hou, Hsiaoju Lee, E. James Petersson, Sam Giannakoulias, Jennifer O'Shea, Paul Kotzbauer, Zhude Tu, Chester A. Mathis, Robert H. Mach

Chem. Commun., 2025, 16, 2743-2753

Structure-Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers

Stehouwer JS, Huang G, Saturnino Guarino D, Debnath ML, Polu A, Geib SJ, Lopresti B, Ikonomovic MD, Mason N, Mach RH, Mathis CA

Journal of Medicinal Chemistry 2025, 68, 6462-6492

Strategic Modulation of Polarity and Viscosity Sensitivity of Bimane Molecular Rotor-Based Fluorophores for Imaging α‐Synuclein

Venkatesh Y, Narayan KB, Baumgart T, Petersson EJ

Journal of The American Chemical Society 2025, 147, 15115-15125.

Replication and reliability of Parkinson’s disease clinical subtypes

Cash TV, Lessov-Schlaggar CN, Foster ER, Myers PS, Jackson JJ, Maiti B, Kotzbauer PT, Perlmutter JS, Campbell MC

Parkinsonism and Related Disorders 2024, 1-8

Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye†

Yarra Venkatesh, Nicholas P. Marotta,  Virginia M.-Y. Lee, and E. James Petersson

Chemical Science 2024, 15 (16), 6053-6063

Development of Pyridothiophene Compounds for PET Imaging of α-Synuclein

Anna Pees, Junchao Tong, Saritha Birudaraju, Yogeshkumar S. Munot, Steven H. Liang, Dinahlee Saturnino Guarino, Robert Mach, Chester A. Mathis, and Neil Vasdev

Chemistry A European Journal 2024, 1-16
 

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy

Ho Young Kim, Wai Kit Chia, Chia-Ju Hsieh, Dinahlee Saturnino Guarino, Thomas J A Graham, Zsofia Lengyel-Zhand, Mark Schneider, Cosette Tomita, Marshall G Lougee, Hee Jong Kim, Vinayak V Pagar, Hsiaoju Lee, Catherine Hou, Benjamin A Garcia, E James Petersson, Jennifer O'Shea, Paul T Kotzbauer, Chester A Mathis, Virginia M-Y Lee, Kelvin C Luk, Robert H Mach

Journal of Medcinal Chemistry 2023, 12185-12202

In Silico Discovery and Subsequent Characterization of Potent 4RTauopathy Positron Emission Tomography Radiotracers

Thomas J. A. Graham, anton Lindberg, Junchao Tong, Jeffrey S. Stehouwer, Neil Vasdev, Robert H. Mach, and Chester A. Mathis

Journal of Medicinal Chemistry 2023, 10628-10638

FRETing about the details: Case studies in the use of a genetically encoded fluorescent amino acid for distance-dependent energy transfer

Michael B. Cory, Chloe M. Jones, Kyle D. Shaffer, Yarra Venkatesh, Sam Giannakoulias, Ryann M. Perez, Marshall G. Lougee, Eshe Hummingbird, Vinayak V. Pagar, Christina M. Hurley, Allen Li, Robert H. Mach, Rahul M. Kohli, E. James Petersson

The Protein Society 2023, 1-19

Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development

Chia-Ju Hsieh, Sam Giannakoulias, E. James Petersson and Robert H. Mach

Pharmaceuticals 2023 16 (317), 1-19

Identifcation of a Putative α‑synuclein Radioligand Using an in silico Similarity Search

Bieneke Janssen, Guilong Tian, Zsofa Lengyel‑Zhand, Chia‑Ju Hsieh, Marshall G. Lougee, Aladdin Riad, Kuiying Xu, Catherine Hou, Chi‑Chang Weng, Brian J. Lopresti, Hee Jong Kim, Vinayak V. Pagar, John J. Ferrie, Benjamin A. Garcia, Chester A. Mathis, Kelvin Luk, E. James Petersson, Robert H. Mach

Molecular Imaging and Biology 2023

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples

Laura N. Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, Chia-Ju Hsieh, Mark E. Schneider Jr., Kimberly J. Edwards, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski and Robert H. Mach

Frontiers in Aging Neuroscience 2021 13 (704041), 1-14

Radiosynthesis, In Vitro and In Vivo Evaluation of [¹⁸F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies

Anton Lindberg, Ashley C. Knight, Daniel Sohn, Laszlo Rakos, Junchao Tong, April Radelet, N. Scott Mason, Jeffrey S. Stehouwer, Brian J. Lopresti, William E. Klunk, Johan Sandell, Alexander Sandberg, Per Hammarström, Samuel Svensson, Chester A. Mathis, and Neil Vasdev

ACS Chemical Neuroscience 2021 12 (4), 596-602

Synthesis and characterization of high affinity fluorogenic a-synuclein probes

Zsofia Lengyel-Zhand, John J. Ferrie, Bieneke Janssen, Chia-Ju Hsieh, Thomas Graham, Kui-ying Xu, Conor M. Haney, Virginia M.-Y. Lee, John Q. Trojanowski, E. James Petersson and Robert H. Mach

ChemComm 2020 56, 3567-3570

Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

Jessica E. Rexach, Damon Polioudakis, Anna Yin, Vivek Swarup, Timothy S. Chang, Tam Nguyen, Arjun Sarkar, Lawrence Chen, Jerry Huang, Li-Chun Lin, William Seeley, John Q. Trojanowski, Dheeraj Malhotra, and Daniel H. Geschwind

Cell Reports 2020 33 (7)

Identification of a nanomolar affinity a-synuclein fibril imaging probe by ultra-high throughput in silico screening

John J. Ferrie, Zsofia Lengyel-Zhand, Bieneke Janssen, Marshall G. Lougee, Sam Giannakoulias, Chia-Ju Hsieh, Vinayak Vishnu Pagar, Chi-Chang Weng, Hong Xu, Thomas J. A. Graham, Virginia M.-Y. Lee, Robert H. Mach and E. James Petersson

Chemical Science 2020 11, 12746-12754