Jason D. Christie

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
717 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Porteous MK, Diamond JM, Christie JD: Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation. Curr Opin Organ Transplant 20(5): 506-14, October 2015.

Christie JD, Vaslef S, Chang PK, May AK, Gunn SR, Yang S, Hardes K, Kahl L, Powley WM, Lipson DA, Bayliffe AI, Lazaar AL: A Randomized Dose-Escalation Study of the Safety and Anti-Inflammatory Activity of the p38 Mitogen-Activated Protein Kinase Inhibitor Dilmapimod in Severe Trauma Subjects at Risk for Acute Respiratory Distress Syndrome. Crit Care Med 43(9): 1859-69, September 2015.

Shah R J, Diamond J M, Cantu E, Flesch J, Lee J C, Lederer D J, Lama V N, Orens J, Weinacker A, Wilkes D S, Roe D, Bhorade S, Wille K M, Ware L B, Palmer S M, Crespo M, Demissie E, Sonnet J, Shah A, Kawut S M, Bellamy S L, Localio A R, Christie J D: Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation. American Journal of Transplantation epub ahead of print, Apr 2015.

Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch III JP, Saggar R, Ardehali A, Ware LB, Christie JD, Belperio JA, Looney MR: Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction After Lung Transplantation. American Journal of Respiratory and Critical Care Medicine 191(4): 455-463, Apr 2015.

Ortego A, Gaieski DF, Fuchs BD, Jones T, Halpern SD, Small DS, Sante SC, Drumheller B, Christie JD, Mikkelsen ME: Hospital-Based Acute Care Use in Survivors of Septic Shock. Crit Care Med 43(4): 729-737, Apr 2015.

Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP: Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. Human Molecular Genetics 24(6): 1801-12, Mar 2015.

Whittaker Stacey-Ann, Fuchs Barry D, Gaieski David F, Christie Jason D, Goyal Munish, Meyer Nuala J, Kean Craig, Small Dylan S, Bellamy Scarlett L, Mikkelsen Mark E: Epidemiology and outcomes in patients with severe sepsis admitted to the hospital wards. Journal of critical care 30(1): 78-84, Feb 2015.

Cantu E, Shah RJ, Lin W, Daye ZJ, Diamond JM, Suzuki Y, Ellis JH, Borders CF, Andah GA, Beduhn B, Meyer NJ, Ruschefski M, Aplenc R, Feng R, Christie JD: Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation. The Journal of Thoracic and Cardiovascular Surgery 149(2): 596-602, Feb 2015.

Eberlein M, Reed RM, Bolukbas S, Diamond JM, Wille KM, Orens JB, Brower RG, Christie JD: Lung size mismatch and primary graft dysfunction after bilateral lung transplantation. The Journal of Heart and Lung Transplantation 34(2): 233-240, Feb 2015.

Young J C, Chehoud C, Bittinger K, Bailey A, Diamond J M, Cantu E, Haas A R, Abbas A, Frye L, Christie J D, Bushman F D, Collman R G: Viral metagenomics reveal blooms of anelloviruses in the respiratory tract of lung transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15(1): 200-9, Jan 2015.

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Last updated: 01/08/2016
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