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Penn Center for AIDS Research

Katharine J Bar

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Assistant Professor of Medicine
Attending Physician, Infectious Diseases, Hospital of the University of Pennsylvania
Physician, International Travel Medicine Clinic, Perelman Center for Advanced Medicine
Director, Penn CFAR Viral and Molecular Core
Department: Medicine

Contact information
502 D Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104-6073
Office: (215) 573-8497
Fax: (215) 349-5111
Graduate Group Affiliations
Education:
BA (Biochemistry and African History, Honors)
Northwestern University, Evanston, IL, 1997.
MD
University of Iowa College of Medicine, Iowa City, IA, 2002.
Post-Graduate Training
Intern and Resident, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, 2002-2005.
Chief Medical Resident, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, 2005-2006.
Fellow Division of Infectious Diseases, Department of Medicine, University of Alabama School of Medicine, Birmingham, AL, 2006-2009.
Clinical and PostDoctoral Research Fellow, Division of Infectious Diseases, Department of Medicine, University of Alabama School of Medicine, Birmingham, AL, 2007-2009.
Chief Fellow Division of Infectious Disease, Department of Medicine, University of Alabama School of Medicine, Birmingham, AL, 2008-2009.
Certifications
Diplomate, National Board of Medical Examiners, 2003.
Diplomate, American Board of Internal Medicine, No. 265961, 2005.
Diplomate, American Board of Internal Medicine, Subspecialty Board, Infectious Disease, No. 265961, 2009.
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Description of Clinical Expertise

HIV care, general infectious disease care

Description of Research Expertise

We study the basic mechanisms of transmission, pathogenesis and persistence in HIV and other chronic viral infections.

Current projects include:

1. The HIV transmission bottleneck and virus phenotype in injection drug users

2. The viral dynamics of rebound viremia upon cART interruption, both in the presence and absence of treatment and curative strategies

3. The neutralization properties of SIV challenge swarms and their transmitted/founder viruses

4. The genetic signatures of Herpes Simplex Virus immune escape from vaccine pressure


Lab Personnel:

Benjamin Scheinfeld, technician
D. Brenda Salantes, graduate student

Selected Publications

Lynn N Bertagnolli , Joseph Varriale, Sarah Sweet, Jacqueline Brockhurst , Francesco R Simonetti , Jennifer White , Subul Beg, Kenneth Lynn, Karam Mounzer, Ian Frank, Pablo Tebas, Katharine J Bar , Luis J Montaner, Robert F Siliciano, Janet D Siliciano : Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1. Proceedings of the National Academy of Sciences 117(50): 32066-32077, Nov 2020.

Roark RS, Li H, Williams WB, Chug H, Mason RD, Gorman J, Wang S, Lee FH, Rando J, Bonsignori M, Hwang KK, Saunders KO, Wiehe K, Moody MA, Hraber PT, Wagh K, Giorgi EE, Russell RM, Bibollet-Ruche F, Liu W, Connell J, Smith AG, DeVoto J, Murphy AI, Smith J, Ding W, Zhao C, Chohan N, Okumura M, Rosario C, Ding Y, Lindemuth E, Bauer AM, Bar KJ, Ambrozak D, Chao CW, Chuang GY, Geng H, Lin BC, Louder MK, Nguyen R, Zhang B, Lewis MG, Raymond D, Doria-Rose NA, Schramm CA, Douek DC, Roederer M, Kepler TB, Kelsoe G, Mascola JR, Kwong PD, Korber BT, Harrison SC, Haynes BF, Hahn BH, Shaw GM. : Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science abd2638, Nov 2020.

Berendam SJ, Styles TM, Morgan-Asiedu PK, Tenney D, Kumar A, Obregon-Perko V, Bar KJ, Saunders KO, Santra S, De Paris K, Tomaras GD, Chahroudi A, Permar SR, Amara RR, Fouda GG: Systematic assessment of antiviral potency, breadth, and synergy of triple broadly neutralizing antibody combinations against Simian-Human Immunodeficiency Viruses. Journal of Virology JVI.01667-20, Nov 2020.

Dashti A, Waller C, Mavigner M, Schoof N, Bar KJ, Shaw GM, Vanderford T, Liang S, Lifson J, Dunham RM, Ferrari G, Tuyishime M, Lam CK, Nordstrom JL, Margolis DM, Silvestri G, Chahroudi A: SMAC mimetic plus triple combination bispecific HIVxCD3 DART® molecules in SHIV.C.CH505-infected, ART-suppressed rhesus macaques. Journal of Virology VI.00793-20.(doi: 10.1128/JVI.00793-20), Aug 2020.

Bauer AM, Ziani W, Lindemuth E, Kuri-Cervantes L, Li H, Lee FH, Watkins M, Xu H, Veazey R, Bar KJ: Novel Transmitted/Founder Simian-Human Immunodeficiency Viruses for Human Immunodeficiency Virus Latency and Cure Research. Journal of Virology 94(8; e01659-19), April 2020.

Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini M.: CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruptio. Nature Medicine 26(4): 519-528, Apr 2020.

Goswami R, Nelson AN, Tu JJ, Dennis M, Feng L, Kumar A, Mangold J, Mangan RJ, Mattingly C, Curtis AD 2nd, Obregon-Perko V, Mavigner M, Pollara J, Shaw GM, Bar KJ, Chahroudi A, De Paris K, Chan C, Van Rompay KKA, Permar SR: Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model MBio 10(5): pii: e01971-19, Sep 2019.

Bar KJ, Coronado E, Hensley-McBain T, O'Connor MA, Osborn JM, Miller C, Gott TM, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Shaw GM, Klatt NR, Manuzak JA: Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology J Virol 93(18): pii: e00372-19, Sep 2019.

Nelson AN, Goswami R, Dennis M, Tu J, Mangan RJ, Saha PT, Cain DW, Curtis AD, Shen X, Shaw GM, Bar K, Hudgens M, Pollara J, De Paris K, Van Rompay KKA, Permar SR: Simian-Human Immunodeficiency Virus SHIV CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes J Virol Page: pii: e00168-19, Jul 2019.

Zahid MN, Wang S, Learn GH, Abt PL, Blumberg EA, Reese PP, Goldberg DS, Shaw GM, Bar KJ: High multiplicity infection following transplantation of hepatitis C virus-positive organs. J Clin Invest 130: pii: 127203, May 2019.

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Last updated: 12/21/2020
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