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Penn Center for AIDS Research

Katharine J Bar

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Assistant Professor of Medicine
Attending Physician, Infectious Diseases, Hospital of the University of Pennsylvania
Physician, International Travel Medicine Clinic, Perelman Center for Advanced Medicine
Director, Penn CFAR Viral and Molecular Core
Department: Medicine

Contact information
502 D Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104-6073
Office: (215) 573-8497
Fax: (215) 349-5111
Graduate Group Affiliations
Education:
BA (Biochemistry and African History, Honors)
Northwestern University, Evanston, IL, 1997.
MD
University of Iowa College of Medicine, Iowa City, IA, 2002.
Post-Graduate Training
Intern and Resident, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, 2002-2005.
Chief Medical Resident, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, 2005-2006.
Fellow Division of Infectious Diseases, Department of Medicine, University of Alabama School of Medicine, Birmingham, AL, 2006-2009.
Clinical and Post Doctoral Research Fellow, Division of Infectious Diseases, Department of Medicine, University of Alabama School of Medicine, Birmingham, AL, 2007-2009.
Chief Fellow Division of Infectious Disease, Department of Medicine, University of Alabama School of Medicine, Birmingham, AL, 2008-2009.
Certifications
Diplomate, National Board of Medical Examiners, 2003.
Diplomate, American Board of Internal Medicine, No. 265961, 2005.
Diplomate, American Board of Internal Medicine, Subspecialty Board, Infectious Disease, No. 265961, 2009.
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Description of Clinical Expertise

HIV care, general infectious disease care

Description of Research Expertise

The Bar Lab studies novel approaches to HIV prevention and cure. Our current research focuses on:
(i) characterizing the viral dynamics and host immune responses during virus suppression and treatment interruption,
(ii) developing NHP models that faithfully recapitulate HIV-1 latency and rebound, and
(iii) developing antibody-based interventions.

Selected Publications

Obregon-Perko V, Bricker KM, Mensah G, Uddin F, Rotolo L, Vanover D, Desai Y, Santangelo PJ, Jean S, Wood JS, Connor-Stroud FC, Ehnert S, Berendam SJ, Liang S, Vanderford TH, Bar KJ, Shaw GM, Silvestri G, Kumar A, Fouda GG, Permar SR, Chahroudi A: Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART. JCI Insight 6(23), Dec 2021 Notes: e152526. doi: 10.1172/jci.insight.152526.

Bar KJ, Shaw PA, Choi GH, Aqui N, Fesnak A, Yang JB, Soto-Calderon H, Grajales L, Starr J, Andronov M, Mastellone M, Amonu C, Feret G, DeMarshall M, Buchanan M, Caturla M, Gordon J, Wanicur A, Monroy MA, Mampe F, Lindemuth E, Gouma S, Mullin AM, Barilla H, Pronina A, Irwin L, Thomas R, Eichinger RA, Demuth F, Luning Prak ET, Pascual JL, Short WR, Elovitz MA, Baron J, Meyer NJ, Degnan KO, Frank I, Hensley SE, Siegel DL, Tebas P: A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia. J Clin Invest 131(24): e155114, December 2021.

O'Brien MP, Forleo-Neto E, Musser BJ, Isa F, Chan KC, Sarkar N, Bar KJ, Barnabas RV, Barouch DH, Cohen MS, Hurt CB, Burwen DR, Marovich MA, Hou P, Heirman I, Davis JD, Turner KC, Ramesh D, Mahmood A, Hooper AT, Hamilton JD, Kim Y, Purcell LA, Baum A, Kyratsous CA, Krainson J, Perez-Perez R, Mohseni R, Kowal B, DiCioccio AT, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD, Weinreich DM; Covid-19 Phase 3 Prevention Trial Team.: Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. N Engl J Med 385(13): 1185-1195, September 2021 Notes: doi: 10.1056/NEJMoa2109682. Epub 2021 Aug 4.

Liu W, Russell RM, Bibollet-Ruche F, Skelly AN, Sherrill-Mix S, Freeman DA, Stoltz R, Lindemuth E, Lee FH, Sterrett S, Bar KJ, Erdmann N, Gouma S, Hensley SE, Ketas T, Cupo A, Cruz Portillo VM, Moore JP, Bieniasz PD, Hatziioannou T, Massey G, Minyard MB, Saag MS, Davis RS, Shaw GM, Britt WJ, Leal SM Jr, Goepfert P, Hahn BH: Predictors of Nonseroconversion after SARS-CoV-2 Infection. Emerg Infect Dis 27(9):2454-2458(9): 2454-2458, September 2021 Notes: DOI: 10.3201/eid2709.211042.

Tebas P, Jadlowsky JK, Shaw PA, Tian L, Esparza E, Brennan AL, Kim S, Naing SY, Richardson MW, Vogel AN, Maldini CR, Kong H, Liu X, Lacey SF, Bauer AM, Mampe F, Richman LP, Lee G, Ando D, Levine BL, Porter DL, Zhao Y, Siegel DL, Bar KJ, June CH, Riley JL: CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication. J Clin Invest 131(7): e144486, April 2021.

Li H, Wang S, Lee FH, Roark RS, Murphy AI, Smith J, Zhao C, Rando J, Chohan N, Ding Y, Kim E, Lindemuth E, Bar KJ, Pandrea I, Apetrei C, Keele BF, Lifson JD, Lewis MG, Denny TN, Haynes BF, Hahn BH, Shaw GM: New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure. J Virol 71(21): e00071-21, March 2021 Notes: doi: 10.1128/JVI.00071-21.

Ziani W, Bauer A, Lu H, Wang X, Wu X, Bar KJ, Li H, Liu D, Shaw GM, Veazey RS, Xu H: Immune responses and viral persistence in SHIV.C.CH848-infected rhesus macaques. J Virol 2198(20): e02198-20, February 2021 Notes: doi: 10.1128/JVI.02198-20.

Gondim MVP, Sherrill-Mix S, Bibollet-Ruche F, Russell RM, Trimboli S, Smith AG, Li Y, Liu W, Avitto AN, DeVoto JC, Connell J, Fenton-May AE, Pellegrino P, Williams I, Papasavvas E, Lorenzi JCC, Salantes DB, Mampe F, Monroy MA, Cohen YZ, Heath S, Saag MS, Montaner LJ, Collman RG, Siliciano JM, Siliciano RF, Plenderleith LJ, Sharp PM, Caskey M, Nussenzweig MC, Shaw GM, Borrow P, Bar KJ, Hahn BH: Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption. Sci Transl Med 13(576), January 2021.

Obregon-Perko V, Bricker KM, Mensah G, Uddin F, Kumar MR, Fray EJ, Siliciano RF, Schoof N, Horner A, Mavigner M, Liang S, Vanderford T, Sass J, Chan C, Berendam SJ, Bar KJ, Shaw GM, Silvestri G, Fouda GG, Permar SR, Chahroudi A: Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4+ T Cells. J Virol 95(2): e01669-20, December 2020 Notes: doi: 10.1128/JVI.01669-20.

Bertagnolli LN , Varriale J, Sweet S, Brockhurst J, Simonetti FR, White J , Beg S, Lynn K, Mounzer K, Frank I, Tebas P, Bar KJ, Montaner LJ, Siliciano RF, Siliciano JD : Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1. Proceed Nat Acad Sci 117(50): 32066-32077, November 2020.

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Last updated: 12/10/2021
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