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Penn Center for AIDS Research

Andrea Facciabene

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Research Associate Professor of Radiation Oncology
co-Director ACC Microbiome shared resource, UPENN
Department: Radiation Oncology

Contact information
University of Pennsylvania Perelman School of Medicine
Department of Radiation Oncology
Smilow Center for Translational Research Rm. 8-133
3400 Civic Center Blvd., Bldg 421
Philadelphia, PA 19104
Office: 215-746-7071
Fax: 215-898-0090
Education:
BS (Pharmaceutical Biotechnology Science (summa cum laude))
University of Bologna, Bologna, Italy (Thesis: Centre of Drug Discovery, L'Aquila, Italy) Summa Cum Laude, 2000.
PhD (Molecular and Cellular Biology)
University of Perugia, Perugia, Italy. In collaboration with the Univ of California San Diego, San Diego, CA (coursework 11/01-5/06), 2006.
Post-Graduate Training
Research Fellowship, Gene Therapy, IRBM, Istituto di Ricerche di Biologia Molecolare-"P. Angeletti" (Merck & Co), Rome, Italy, 2000-2001.
Postdoctoral Research Fellowship, University of California San Diego, Department of Cancer Research San Diego, CA , 2005-2006.
Postdoctoral Research Fellowship, University of Pennsylvania, Ovarian Cancer Research Center , 2006-2007.
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Description of Research Expertise

Dr. Andrea Facciabene’s laboratory is focused on cancer immunotherapy and the investigation of the network of immune responses to tumors, combining basic research and clinical investigation. The Facciabene Lab goals are to advance understanding of tumor immunology and to use the new findings to develop efficacious new therapies. Our basic research includes the development of two new vaccination strategies: one uses mitochondria isolated from tumors, the other utilizes new tumor vasculature antigen. We also study regulation of anticancer immune response by the gut microbiota. Our clinic research includes the development of new preclinical immunotherapies.

Selected Publications

Chen X, Jin C, Facciabene A, Guo X, Zhang Y. Editorial: : Deciphering the Microbiome-Immunity-Cancer Axis. 2. Front Immunol. 2022 Apr 14;13:897811. doi: 10.3389/fimmu.2022.897811. eCollection 202 2022.

Anstadt EJ, Chu B, Yegya-Raman N, Han X, Doucette A, Poirier K, Mohiuddin JJ, Maity A, Facciabene A, Amaravadi RK, Karakousis GC, Cohen JV, Mitchell TC, Schuchter LM, Lukens JN.: Moderate Colitis Not Requiring IV Steroids Is Associated with Improved Survival in Stage IV Melanoma after Anti-CTLA4 Monotherapy, But Not Combination Therapy. Oncologist. 2022 Jun 6:oyac108. doi: 10.1093/oncolo/oyac108. Online ahead of print. PMID: 35666292 2022.

mith M, Dai A, Ghilardi G, Amelsberg KV, Devlin SM, Pajarillo R, Slingerland JB, Beghi S, Herrera PS, Giardina P, Clurman A, Dwomoh E, Armijo G, Gomes ALC, Littmann ER, Schluter J, Fontana E, Taur Y, Park JH, Palomba ML, Halton E, Ruiz J, Jain T, Pennisi M, Afuye AO, Perales MA, Freyer CW, Garfall A, Gier S, Nasta S, Landsburg D, Gerson J, Svoboda J, Cross J, Chong EA, Giralt S, Gill SI, Riviere I, Porter DL, Schuster SJ, Sadelain M, Frey N, Brentjens RJ, June CH, Pamer EG, Peled JU, Facciabene A*, van den Brink MRM, Ruella M. : gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy. Nat Med. 2022 Mar 14. doi: 10.1038/s41591-022-01702-9. PMID: 35288695 Co-last and Co-Corresponding author 2022.

Pierini S, Tanyi JL, Simpkins F, George E, Uribe-Herranz M, Drapkin R, Burger R, Morgan MA, Facciabene A. : Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target. JCI Insight. 2021 Aug 20;5(16). doi: 10.1172/jci.insight.136773. PubMed PMID: 32814714; PubMed Central PMCID: PMC7455139. 2021.

Pierini S, Mishra A, Perales-Linares R, Uribe-Herranz M, Beghi S, Giglio A, Pustylnikov S, Costabile F, Rafail S, Amici A, Facciponte JG, Koumenis C, Facciabene A.: A combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression. J Immunother Cancer. 2021 Feb;9(2):e001636. doi: 10.1136/jitc-2020-001636. PMID: 33563772 2021.

Uribe-Herranz M, Rafail S, Beghi S, Gil-de-Gómez L, Verginadis I, Bittinger K, Pustylnikov S, Pierini S, Perales-Linares R, Blair IA, Mesaros CA, Snyder NW, Bushman F, Koumenis C, Facciabene A. : Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response. J Clin Invest. 130(1): 466-479, Jan 2 2020

Pierini S, Tanyi JL, Simpkins F, George E, Uribe-Herranz M, Drapkin R, Burger R, Morgan MA, Facciabene A.: Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target. JCI Insight 5(16), Aug 2020.

Adams SF, Grimm AJ, Chiang CL, Mookerjee A, Flies D, Jean S, McCann GA, Michaux J, Pak H, Huber F, Neal C, Dangaj D, Bassani-Sternberg M, Rusakiewicz S, Facciabene A, Coukos G, Gimotty PA, Kandalaft LE.: Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes. J Immunother Cancer 8(2), Aug 2020.

Zhao H, Xie L, Clemens JL, Zong L, McLane MW, Arif H, Feller MC, Jia B, Zhu Y, Facciabene A, Ozen M, Lei J, Burd I.: Mouse Bone Marrow-Derived Mesenchymal Stem Cells Alleviate Perinatal Brain Injury Via a CD8+ T Cell Mechanism in a Model of Intrauterine Inflammation. Reprod Sci 27(7): 1465-1476, July 2020.

Chao HH, Karagounis IV, Thomas C, François NB, Facciabene A, Koumenis C, Maity A.: Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation. Oncogene 39(22): 4344-4357, May 2020.

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Last updated: 10/06/2022
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