Penn Center for AIDS Research

Dennis J. Dlugos

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Professor of Neurology at the Children's Hospital of Philadelphia
Director, Pediatric Epilepsy Program, Division of Neurology, The Children's Hospital of Philadelphia
Associate Dean for UME Science and Discovery Curriculum, Perelman School of Medicine at the University of Pennsylvania
Department: Neurology

Contact information
Division of Neurology
Children's Hospital of Philadelphia
34th and Civic Center Blvd
Colket Translational Research Building
1st floor, Room 1200.14
Philadelphia, PA 19104
Office: 215-590-1719
Fax: 215-590-2950
B.A. (Theology)
Loyola Marymount University, Los Angeles, CA, 1983.
M.D. (Medicine)
Columbia University College of Physicians & Surgeons, New York, NY, 1988.
M.S.C.E (Clinical Epidemiology)
Master’s of Science in Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
Post-Graduate Training
Intern in Pediatrics, National Naval Medical Center, Bethesda, MD, 1988-1989.
Resident in Pediatrics, Thomas Jefferson University & Alfred I. Dupont Institute, Philadelphia, PA & Wilmington, DE, 1993-1994.
Resident in Neurology/Child Neurology, University of Pennsylvania Medical Center & The Children’s Hospital of Philadelphia, Philadelphia , 1994-1997.
Fellow in Epilepsy and Clinical Neurophysiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 1997-1999.
Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology, 1998.
Pediatrics (1998 - 2012), American Board of Pediatrics, 1998.
Clinical Neurophysiology with Special Qualifications in Epilepsy Monitoring, American Board of Clinical Neurophysiology, 1999.
Clinical Neurophysiology (1999-2009), American Board of Psychiatry and Neurology, 1999.
Epilepsy, American Board of Psychiatry and Neurology, 2013.
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Description of Research Expertise

Epilepsy Epidemiology
Epilepsy Genetics
Clinical Prediction Models

Description of Clinical Expertise

Pediatric Epilepsy
Epilepsy Genetics
Epilepsy Surgery
Clinical Neurophysiology

Selected Publications

Hahn CD, Jiang Y, Villanueva V, Zolnowska M, Arkilo5 D, Hsiao S, Asgharnejad M, Dlugos D: A phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox–Gastaut syndrome (ELEKTRA). Epilepsia 63: 2671-2683, 2022.

Tarquinio D, Dlugos D, Wheless JW, Desai J, Carrazana E, Rabinowicz AL: Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study. Pediatric Neurology 132: 50-55, 2022.

Knupp KG, Coryell J, Singh RK, Gaillard W, Shellhaas R, Koh S, Mitchell WG, Harini C, Millichap JJ, May A, Dlugos D, Nickels K, Mytinger JR, Keator C, Yozawitz E, Singhal N, Lockrow J, Thomas JF, Juarez-Colunga E: Comparison of cosyntropin, vigabatrin and combination therapy in new onset infantile spasms in a prospective randomized trial. Journal of Child Neurology 37: 186-193, 2022.

Koko M, Motelow JE, Stanley KE, Bobbili DR, Dhindsa RS, May P, Canadian Epilepsy Network, Epi4K Consortium, Epilepsy Phenome/Genome Project (including Dlugos D), EpiPGX Consortium, EuroEPINOMICS-CoGIE Consortium: Association of ultra-rare coding variants with genetic generalized epilepsy: a case control whole exome sequencing study Epilepsia 63: 723-735, 2022.

Sperling MR, Wheless J, Hogan RE, Dlugos D, Cascino G, Liow K, Rabinowicz A, Carrazana E: Use of Second Doses of Diazepam Nasal Spray Across 24 Hours After the Initial Dose for Out-of-Hospital Seizure Clusters: Results From a Phase 3, Open-Label, Repeat-Dose Safety Study. Epilepsia 63: 836-843, 2022.

Millichap JJ, Harden CL, Dlugos DJ, French JA, Butterfield NH, Grayson C, Aycardi E, Pimstone SN: Capturing seizures in clinical trials of anti-seizure medications for KCNQ2 DEE. Epilepsia Open 6: 38-44, 2021.

Epilepsy Phenome/Genome Project, Epi4K Consortium (including Dlugos, DJ) : Diverse genetic causes of polymicrogyria with epilepsy Epilepsia 62: 973-983, 2021.

Segal EB, Tarquinio D, Miller I, Wheless JW, Dlugos D, Biton V, Cascino GD, Desai J, Hogan RE, Liow K, Sperling MR, Vazquez B, Cook DF, Rabinowicz AL, Carrazana E, for the DIAZ.001.05 Study Group: Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: An Interim Subgroup Analysis from a Phase 3, Long-term, Open-label Safety Study. Epilepsia 62: 1442-50, 2021.

Fitzgerald MP, Kaufman MC, Massey SL, Fridinger S, Prelack M, Ellis C, Ortiz-Gonzalez X, Fried LE, DiGiovine MP, CHOP Pediatric Epilepsy Program Collaborative, Melamed S, Malcolm M, Banwell B, Stephenson D, Witzman SM, Gonzalez A, Dlugos D, Kessler SK, Goldberg EM, Abend NS, Helbig I: Assessing seizure burden in pediatric epilepsy using an electronic medical record-based tool through a common data element approach. Epilepsia in press, 2021.

Wheless JW, Miller I, Hogan RE, Dlugos D, Biton V, Cascino GD for the DIAZ.001.05 Study Group: Final results from a phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. Epilepsia 62: 2485-2495, 2021.

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Last updated: 10/25/2022
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