Publications

E. Bergaggio*, W.T. Tai*, A. Aroldi, E. Landoni, M. Nuesch, I. Mota, J. Metovic, L. Ma, D. Alvarado, R. B. Blasco, T. Li, D. Klein, D. J. Irvine, M. Papotti, B. Savoldo, G. Dotti, R. Chiarle. ALK chimeric antigen receptor T cells cooperate with ALK inhibitors to target neuroblastoma cells. In preparation. (2022)

 L. Ma, D Morgan, C Backlund, I Sulkaj, W Abraham, N Li, C. Love, D. J. Irvine. A synthetic vaccine bridges CAR T cells and endogenous T cells to target tumors with pre-existing antigenic heterogeneity. In preparation. (2022)

 L. Ma, W Ian, N. K. Mehta, B. Cossette, I Sulkaj, S. Harrison, D. Wittrup, D. J. Irvine. De novo engineered mimotope as a customized vaccine to enhance CAR T cell therapy. In preparation. (2022)

E Dane, A Belessiotis-Richards, C Backlund, J Wang, K Hidaka, L Milling, S Bhagchandani, M Melo, NA Li, N Donahue, K Ni, L Ma, M Okaniwa, M Stevens, A Alexander-Katz, D. J. Irvine. Delivery of STING agonists using tumor-penetrating PEGylated lipid nanodiscs primes sustained anti-cancer immunity. Nat Materials, (2022)

 E. Alspach, R. D. Chow, S. Demehri, J. L. Guerriero, S. Gujar, F. J. Hartmann, B. A. Helmink, W. H. Hudson, W. J. Ho, L. Ma, B. B. Maier, V. I. Maltez, B. C. Miller, A. E. Moran, E. M. Parry, P. S. Pillai, S. Rafiq, M. Reina-Campos, P. C. Rosato, N.-P. Rudqvist, M. K. Ruhland, I. Sagiv-Barfi, A. D. Sahu, R. M. Samstein, C. M. Schürch, D. R. Sen, D. S. Thommen, Y. Wolf, R. Zappasodi, Supporting the next generation of scientists to lead cancer immunology research. Cancer Immunol Res 9, canimm.0519.2021 (2021).

​ L. Ma, T. Dichwalkar, J. Y. H. Chang, B. Cossette, D. Garafola, A. Q. Zhang, M. Fichter, C. Wang, S. Liang, M. Silva, S. Kumari, N. K. Mehta, W. Abraham, N. Thai, N. Li, K. D. Wittrup, D. J. Irvine, Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor, Science 365, 162–168 (2019).

 N. Momin, N. K. Mehta *, N. R. Bennett *, L. Ma *, J. R. Palmeri, M. M. Chinn, E. A. Lutz, B. Kang, D. J. Irvine, S. Spranger, K. D. Wittrup, Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy, Sci Transl Med 11, eaaw2614 (2019). [* Equal contribution]

 Chensu Wang*, Murillo Silva*, Leyuan Ma*, Bioengineering Innovative Solutions for Cancer. Elsevier (2019) [* Equal contribution]

L. Ma*, M. L. Pak*, J. Ou, J. Yu, P. St Louis, Y. Shan, L. Hutchinson, S. Li, M. A. Brehm, L. J. Zhu, M. R. Green, Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells, Proc. Natl. Acad. Sci. U.S.A. 116, 10482–10487 (2019). [* Equal contribution]

 L. Ma, J. I. Boucher, J. Paulsen, S. Matuszewski, C. A. Eide, J. Ou, G. Eickelberg, R. D. Press, L. J. Zhu, B. J. Druker, S. Branford, S. A. Wolfe, J. D. Jensen, C. A. Schiffer, M. R. Green, D. N. Bolon, CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy, Proc. Natl. Acad. Sci. U.S.A. 114, 11751–11756 (2017).

 L. Ma, J. Roderick, M. A. Kelliher, M. R. Green, High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML, Methods Mol. Biol. 1465, 159–173 (2016).