The C.U.R.E. Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery Marijuana Study

FAQ

What is the CURE Marijuana Study?

The University of Pennsylvania’s Treatment Research Center is currently conducting a research study to investigate whether or not a medication, baclofen, can prevent or reduce craving for marijuana.  This study is also investigating predictors of relapse and recovery in people addicted to marijuana through the use of brain (fMRI) and behavioral measures (computer tasks & questionnaires). 

What is Baclofen?

Baclofen is an FDA-approved medication safely used to treat muscle spasms for over 35 years.  Baclofen is not FDA-approved for the treatment of marijuana dependence.  Baclofen has a low side-effect profile.  The most common side effect is drowsiness, which, if it is experienced, goes away in a few days.

What is a placebo?

A placebo is a sugar pill.  You will have a 50% chance of receiving placebo and a 50% chance of receiving baclofen. Neither you nor the study team will know whether you are receiving baclofen or placebo.

What is fMRI?

Functional Magnetic Resonance Imaging (fMRI) is a painless technique that takes special pictures of your brain and does not involve radiation or injections.  In this study it is used to measure brain reactions/responses to marijuana cues.

How long will I be involved in the study?

You will participate in this study for about 6 months.  Your participation will involve 12 weeks of baclofen or placebo as well as drug counseling and behavioral therapy during the treatment period and 12 weeks of follow-up visits.

Is the study confidential?

All of the information that you provide in this study will be kept strictly confidential.  You will be assigned a subject code number so your name will not be associated with information collected or identified anywhere in the research results.

How will I benefit from this study?

Addiction is a major problem in our society and as of yet there is no FDA-approved intervention to treat marijuana dependence.  This study may provide information that leads to effective strategies (behavioral training, medications, or both) to treat marijuana dependence and possibly prevent relapse.  You will be contributing to our knowledge about ways to help others with marijuana use problems.

Can I choose to leave the study?

Your participation in the study is completely voluntary.  You may withdraw at any time without affecting your present or future care.

Will I have to pay for my medication or therapy?

There is no charge for the medication, therapy or any assessment or lab tests you will receive in this study.

Will I be compensated?

You will be compensated for research assessments.

How do I know if I am eligible for this study?

Men and women ages 18-60 who use marijuana may be eligible for this study.  Please call 1-800-528-5527 to speak to a research assistant who will conduct an initial phone screen to help determine your eligibility for this study.  If you pass the initial phone screen you will be scheduled to come in for additional screening procedures to determine final eligibility.


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